Cerebrospinal fluid zinc concentrations in febrile convulsions.

Bz, Garty; Olomucki, R; Lerman‐Sagie, T.; Nitzan, M

doi:10.1136/adc.73.4.338

Cited by 29 publications

(32 citation statements)

References 23 publications

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“…One possible function is the release of GABA into the cerebrospinal fluid. GABA has been detected in cerebrospinal fluid and is thought to be of central nervous system origin (Löscher, 1982;Garty et al, 1995). Alternatively the GABA produced by these neurons may function as a neurotransmitter at its synapses and may play a role in the formation of synapses in early development.…”

Section: Ka Cerebrospinal Fluid-contacting Neurons Express Gad65 and mentioning

confidence: 99%

Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish

1998

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We describe the isolation two glutamic acid decarboxylase (GAD) cDNAs from zebrafish with over 84% identity to human GAD65 and GAD67. In situ hybridization studies revealed that both GAD65 and GAD67 were expressed in the early zebrafish embryo during the period of axonogenesis, suggesting a role for GABA prior to synapse formation. Both GAD genes were detected in the telencephalon, in the nucleus of the medial longitudinal fasciculus in the midbrain, and at the border regions of the rhombomeres in the rostral hindbrain. In the caudal hindbrain, only GAD67 was detected (in neurons with large-caliber axons). In the spinal cord, both GAD genes were detected in dorsal longitudinal neurons, commissural secondary ascending neurons, ventral longitudinal neurons, and Kolmer-Agduhr neurons. Immunohistochemistry for gamma-aminobutyric acid (GABA) revealed that GABA is produced at all sites of GAD expression, including the novel cells in the caudal hindbrain. These results are discussed in the context of the hindbrain circuitry that supports the escape response. We conclude that fish, like mammals, have two GAD genes. The zebrafish GAD65 and GAD67 are present in identified neurons in the forebrain, midbrain, hindbrain, and spinal cord, and they catalyze the production of GABA in the developing embryo.

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Section: Ka Cerebrospinal Fluid-contacting Neurons Express Gad65 and mentioning

confidence: 99%

Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish

1998

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“…In another study by Heydarian et al, it was reported that the serum level of zinc was significantly lower in children with simple febrile seizure compared to febrile children without seizure 10 . Garty et al reported that there was no relation between CSF zinc level and febrile seizure 11 . Considering the above-mentioned findings, we decided to design a study to investigate the serum zinc level in patients with febrile seizures in comparison with febrile children without seizure.…”

Section: Introductionmentioning

confidence: 99%

Zinc levels in Febrile Seizure: A Case-Control Study

Joshi¹,

Shetty²

2014

Int Jour of Biomed Res

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“…However, fever and acute infection may have some roles in developing such condition. 19 It is believed that the release of Tumor Necrosis Factor (TNF) and interleukin (IL) during fever or tissue injury may result in reduction of serum zinc level. 13 Izumi Y et al proposed that the hypozincemia during fever trigger the NMDA receptor, one of the members of glutamate family of receptors, which may play an important role in the initiation of epileptic discharge during febrile seizures.…”

Section: Discussionmentioning

confidence: 99%