Cerebrovascular Disease Associated with Marijuana Abuse: A Case Report

Mesec, Anton; Rot, Uroš; Grad, Anton

doi:10.1159/000047653

Cited by 32 publications

(14 citation statements)

References 8 publications

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“…In the literature, 59 case reports of cannabis-related stroke (mean age, 33±12.4 years) were described, and among them there was a majority of men with a sex ratio of 4.9:1. Most of stroke were IS (n=49) 11,12,[14][15][16][17][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] or transient ischemic attacks (n=5). 14,38,39 There is only 1 patient who was described with an hemorrhagic stroke associated with cannabis use.…”

Section: Neurological Complications Of Cannabis Abusementioning

confidence: 99%

Cannabis-related Stroke

Wolff

Armspach

Lauer

et al. 2013

Stroke

113

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Section: Neurological Complications Of Cannabis Abusementioning

confidence: 99%

Cannabis-related Stroke

Wolff

Armspach

Lauer

et al. 2013

Stroke

113

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“…12 CT showed a large subcortical infarction involving the left striatum and posterior internal capsule. Urine toxicology was positive only for cannabinoids, and cardiovascular evaluations were unrevealing.…”

Section: Moussouttasmentioning

confidence: 99%

Cannabis Use and Cerebrovascular Disease

Moussouttas

2004

The Neurologist

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Cannabis use seems to have been causally related to several instances of cerebral ischemia and infarction. Proposed etiologic mechanisms have included cerebral vasospasm, cardioembolization, and systemic hypotension with impaired cerebral autoregulation, but most of the available data points to a vasospastic process. The exact relation of cannabis to cerebrovascular disease remains to be determined.

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“…Most problematic among young marijuana users is the view that marijuana was not harmful (Gruber & Pope, 2002;Hall & Degenhardt, 2006) even though cognitive and psychiatric impairments have been documented in heavy marijuana users (Fletcher et al, 1996;Pope et al, 1996Pope et al, , 2001Ehrenreich et al, 1999;Bolla et al, 2002;Solowij et al, 2002;Fergussion et al, 2006). Strokes in relatively young individuals have also been reported (Cooles & Michaud, 1987;Zarchariah, 1991;Barnes et al, 1992;Lawson & Rees, 1996;MacCarron, 1997;White et al, 2000;Marinella, 2001;Mesec et al, 2001;Alvaro et al, 2002). Related to the cognitive impairments and strokes, altered cerebral blood flow has also been observed in chronic marijuana users during abstinence (Tunving et al, 1986;Amen, & Waugh, 1998;Lundqvist et al, 2001;Block et al, 2002;Herning et al, 2005;Sneider et al, 2006).…”

Section: Introductionmentioning

confidence: 96%

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

Herning

Better

Cadet

2008

Clinical Neurophysiology

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Objective-Marijuana abuse is associated with neurological changes including increases in frontal EEG alpha during abstinence. Research is needed to assess to what extent these EEG patterns are indicative of cerebral perfusion deficits.Methods-We recorded the resting eyes closed EEG of 75 abstinent marijuana users and 33 control subjects. Fifty-six marijuana users used marijuana for less than eight years and 19 used for eight years or more. The EEG evaluation occurred within 72 hours of admission to an inpatient unit. Fiftynine marijuana users remained abstinent for a month and were tested twice. Supplemental psychological and physiological data were also collected.Results-Log alpha2 and beta2 power at posterior sites were significantly lower for the marijuana abusers that used eight years or more than the other marijuana abusers and the control subjects. These EEG changes continued for the month of abstinence. The marijuana users who used marijuana for more than eight years, also, had lower heart rates and thyroid function (T4) compared to the other marijuana users and the control subjects.Conclusions-Chronic marijuana use was also associated with reduced EEG power in alpha and beta bands at posterior sites. These reductions in EEG power appear to be related to cerebral perfusion deficits and/or thyroid function in marijuana abusers.Significance-Our results suggest EEG, cerebral blood flow velocity, cardiovascular and thyroid function alterations in marijuana abuser with an extended period of use. These alterations reflect under arousal in these systems.

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Cerebrovascular Disease Associated with Marijuana Abuse: A Case Report

Cited by 32 publications

References 8 publications

Cannabis-related Stroke

Cannabis-related Stroke

Cannabis Use and Cerebrovascular Disease

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

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