Cerebrovascular occlusive complications in osteopetrosis major

Abstract

We report the case of a 16-year-old patient with osteopetrosis major, complaining of transient sensory and motor disturbances in the left upper limb and dizziness on changing the position of his head. Selective angiography of the cerebral vessels showed severe narrowing of the internal carotid artery within the petrous carotid canal and in its supraclinoid portion. The cervical vertebral arteries showed multiple stenosis within the vertebral canal. These findings are explained by narrowing of the basal foramina by the osteopetrotic bone.

Dysosteosclerosis: a report of three new cases and evolution of the radiological findings

“…The evidence of platyspondyly in the thoracic spine is also in favour of dysosteosclerosis. He had at least two major cerebrovascular accidents resulting in cerebral infarction and although this complication has also been described in patients with osteopetrosis, 14 his medical condition may have contributed. Both bone marrow transplants failed and it is not possible from this isolated case to evaluate the future role of this type of therapy.…”

Neurologic abnormalities in the skeletal dysplasias: A clinical and radiological perspective

“…The severe autosomal recessive form can manifest with multiple cranial nerve palsies, including facial, optic and auditory involvement in infancy [Abdel-al et al, 1994;Al-Mefty et al, 1988;Bartgaski et al, 1989;Benecke et al, 1993;Demirci et al, 1991;Elster et al, 1992;Wilms et al, 1990]. Myelopathy secondary to cervical spine involvement can occur [McCleary et al, 1987].…”

Multimodality Imaging of Osteopetrosis

“…The bone within bone appearance is characteristic and diagnostic which is due to the presence of formation of new abnormal bone within the normal outline of the current shadow which is due to the cyclical nature of the disease. 1,4,5 Irregular condensation of the bone at metaphysis produces parallel plates of dense bone at the ends of long bone which are present in this case. These patients usually present with hypocalcaemia.…”

“…Frequently IOP is distinguished from the malignant form only when a milder clinical course evolves with age. [1][2][3][4][5] Plain radiography and sectional imaging in particular magnetic resonance imaging (MRI) plays important role in the diagnosis of the osteopetrosis and its subtypes. 6,7,8 CASE REPORT: A seven year old male child from a family of lower socio-economic group with a history of abdominal distension and fever since three months and a clinical diagnosis of thalassemia major referred for further investigation to the department of Radiology of Vydehi hospital.…”