“…The prevalence of VRFs (e.g., cardiovascular disease, angina, circulation problems, etc.) increases with age, and VRFs have been empirically linked with the onset and severity of depression in both cross-sectional and longitudinal studies (Lingam et al, 1988;Alexopoulos et al, 1997aAlexopoulos et al, , 1997bKrishnan et al, 1997;Lyness, 2000;Hickie et al, 2003;Oldehinkel et al, 2003;Mast et al, 2004aMast et al, , 2004bKales et al, 2005;Mast et al, 2005;Steffens et al, 2006;Nuyen et al, 2007;Steffens et al, 2007;Mast et al, 2008).…”