Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing

Wu, Haibin; Li, Fangyuan; Wang, Shuaifei; Lu, Jingxiong; Li, Jinquan; Du, Yang; Sun, Xiaolian; Chen, Xiaoyuan; J, Gao; Ling, Daishun

doi:10.1016/j.biomaterials.2017.10.018

Cited by 272 publications

(208 citation statements)

References 65 publications

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“…Wound healing is a dynamic and interactive process involving coagulation, inflammation, tissue formation and remodelling . Excessive oxidative stress is one of the main causes of wound healing impairment . Reactive oxygen species (ROS) arising from inflammatory cells are strongly participated in the pathogenesis of chronic ulcers .…”

Section: Introductionmentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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Hydrogen sulphide (H2S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H2S on skin wound healing are not known well. In the present study, 129S1/SvImJ mice were intraperitoneally injected with NaHS (50 μmol/kg/d) for 2 weeks. Then, a round wound of 6 mm diameter with depth into the dermis was made. The skin wound area, blood perfusion, superoxide production, malondialdehyde (MDA) levels, total antioxidant capacity (T‐AOC), expression of vascular endothelial growth factor (VEGF), dynamin‐related protein 1 (DRP1) and optic atrophy 1 (OPA1) were measured. After NaHS (50 μmol/L) pre‐administration for 4 hours, cell migration rate, DRP1, OPA1 and α–smooth muscle actin (α‐SMA) expression, superoxide production and mitochondrial membrane potential in primary skin fibroblasts were measured. Tube formation in human umbilical vein endothelial cells (HUVECs) and cell migration in human keratinocytes were also measured. The results showed that NaHS pretreatment significantly accelerated wound healing and improved blood flow in the wound after operation. NaHS increased VEGF expression in the wound and promoted tube formation in HUVECs. Meanwhile, NaHS attenuated reactive oxygen species (ROS) production, suppressed MDA level but restored T‐AOC in the wound. NaHS also promoted skin fibroblasts migration and α‐SMA expression after scratch. Moreover, NaHS alleviated ROS, increased mitochondrial membrane potential, decreased DRP1 but enhanced OPA1 expression in skin fibroblasts after scratch. NaHS also accelerated human keratinocytes migration after scratch. Taken together, exogenous H2S supplementary accelerated the skin wound healing, which might be related to oxidative stress inhibition and VEGF enhancement.

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Section: Introductionmentioning

confidence: 99%

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Hua

et al. 2019

Experimental Dermatology

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“…Lee et al expanded this method to prepare fluorescent dye‐doped mesoporous silica NPs decorated with Fe 3 O 4 NPs, which were used for multimodal imaging and drug delivery . BMPA‐mediated coupling was further generalized to decorate silica NPs with QDs, manganese ferrite NPs, and ceria NPs …”

Section: Structures Of Multifunctional Np Platformsmentioning

confidence: 99%

“…Wu et al reported the silica–ceria core–satellite NPs that can be used as a strong tissue adhesive as well as a wound healing agent. [111a] The ROS scavenging activities of the ceria NPs reduced the deleterious effects by oxidative stress, such as cellular senescence, fibrotic scarring, and inflammation at injured sites. The silica NPs provided the tissue adhesive property, which is widely acknowledged …”

Section: Structures Of Multifunctional Np Platformsmentioning

confidence: 99%

Synthesis and Biomedical Applications of Multifunctional Nanoparticles

et al. 2018

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The accumulated knowledge of nanoparticle (NP) synthesis for the last 30 years has enabled the development of functional NPs for biomedical applications. Especially, NPs with multifunctional capabilities are gaining popularity as the demand for versatile and efficient NP agents increases. Various combinations of functional materials are integrated to form multicomponent NPs with designed size, structure, and multifunctionality. Their use as diagnostic and/or therapeutic tools is demonstrated, suggesting their application potentials in healthcare and medical practice. Here, the recent achievements in the synthesis and biomedical applications of multifunctional NPs are summarized. Starting with a brief overview regarding the advances in NP synthesis and accompanying progress in nanobiotechnology, various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems. Following the explanation of the features that multifunctional NP agents can offer, an outlook and a brief comment regarding the future research directions are provided.

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“…Among them ceria nanoparticles (CeNPs) have received much attention because of their proven effectiveness in various disease models and apparent lack of acute toxicities . Multifunctional nanoparticles have also been developed by integrating CeNPs into other biomaterials to empower therapeutic ROS scavenging effects . The autocatalytic conversion between cerium(III) and cerium(IV) oxidation states enables the CeNPs to perform ROS scavenging activity in a potent and self‐regenerative manner .…”

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles Fabricated with 6‐Aminohexanoic Acid that Overcome Systemic Inflammatory Response Syndrome

Jeong

Geun

Kang

et al. 2019

Adv Healthcare Materials

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Systemic inflammatory response syndrome (SIRS) is self‐destructive and uncontrollable inflammatory response of the whole body triggered by infection, trauma, or a variety of severe injuries. Although reactive oxygen species play a pivotal role in the development of SIRS, the trials with conventional antioxidants have failed to improve patient outcome. Ceria nanoparticles (CeNPs) have potent, autocatalytic reactive oxygen species scavenging activities, which may have sufficient therapeutic effects for SIRS. Herein, 3 nm CeNPs are fabricated totally in aqueous phase by using 6‐aminohexanoic acid (6‐AHA) and their Ce3+ to Ce4+ ratio is increased to enhance antioxidative properties. The obtained 6‐AHA‐CeNPs demonstrate strong antioxidative and anti‐inflammatory effects in various biofluids and inflammatory cells. In SIRS animal models, 6‐AHA‐CeNPs are demonstrated to reduce multiple organ injuries and inflammation. Moreover, 6‐AHA‐CeNPs decrease mortality and improve clinical scores of SIRS models. These findings suggest that 6‐AHA‐CeNPs have potential as a therapeutic nanomedicine for SIRS.

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Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing

Cited by 272 publications

References 65 publications

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

Synthesis and Biomedical Applications of Multifunctional Nanoparticles

Ceria Nanoparticles Fabricated with 6‐Aminohexanoic Acid that Overcome Systemic Inflammatory Response Syndrome

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