Ceria–Zirconia Nanoparticles as an Enhanced Multi‐Antioxidant for Sepsis Treatment

Soh, Min; Kang, Dong Wan; Jeong, Han‐Gil; Kim, Dokyoon; Kim, Do Yeon; Yang, Wookjin; Song, Changyeong; Baik, Seungmin; Choi, In Young; Ki, Seul Ki; Kwon, Hyek Jin; Kim, Sang Woo; Kim, Chi Kyung; Lee, Jun Young; Hyeon, Taeghwan

doi:10.1002/anie.201704904

Cited by 281 publications

(222 citation statements)

References 32 publications

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“…Hematoxylin and eosin (H&E) staining and immunohistochemistry analyses of multiple organs were further performed to provide the direct evidence of sepsis management. Cholestasis, mononuclear cell infiltration, erosion, and the ulcer detritus as well as TNF‐α secretion were frequently observed in multiple organ of the sepsis group, while markedly reduced inflammation appeared in the treated group, certifying that Co/PMCS could effectively mitigate the multiple organs damages and inflammatory response (Figure g,h). Moreover, 60 % of the Co/PMCS‐treated animals survived up to 14 days, whereas 90 % of animals died in the control group (Figure f).…”

Section: Resultsmentioning

confidence: 90%

An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

et al. 2020

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Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity and mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely to the specificity and low activity of exploited nanozymes. Herein, an enzyme‐mimicking single‐atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co‐porphyrin centers, which can rapidly obliterate multiple RONS to alleviate sepsis. Co/PMCS can eliminate O2.− and H2O2 by mimicking superoxide dismutase, catalase, and glutathione peroxidase, while removing .OH via the oxidative‐reduction cycle, with markedly higher activity than nanozymes. It can also scavenge .NO through formation of a nitrosyl–metal complex. Eventually, it can reduce proinflammatory cytokine levels, protect organs from damage, and confer a distinct survival advantage to the infected sepsis mice.

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Section: Resultsmentioning

confidence: 90%

An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

et al. 2020

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“…[13] While Ce 3+ is responsible for eliminating superoxide anions (O 2 C À )a nd hydroxyl radicals (COH), Ce 4+ eradicates hydrogen peroxide (H 2 O 2 ). [14] Additionally,C eNP show high pseudo-enzyme activity.F or example,1 .0 mgo fc eria is equivalent to 527 enzyme units (U) of superoxide dismutase (SOD) for neutralizing O 2 C À . [15] Moreover,t he recyclable valence state conversion offers CeNP the opportunity to eradicate ROSs ubstantially.…”

Section: Microglialcellsareresidentimmunecellsinthebraintheymentioning

confidence: 99%

Custom‐Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

Zeng

et al. 2018

Angewandte Chemie

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The neuroprotective effect of ceria nanoparticles in the context of brain disorders has been explained by their antioxidant effect. However,t he in-depth mechanism remains unknown. As resident immune cells in the brain, microglia exert av ariety of functional reprogramming termed as polarization in response to stress stimuli. Herein, custom-made ceria nanoparticles were developed and found to scavenge multiple reactive oxygen species with extremely high efficiency.T hese nanoparticles drove microglial polarization from apro-inflammatory phenotype to an anti-inflammatory phenotype under pathological conditions.P retreatment of these nanoparticles changed the microglial function from detrimental to protective for the neuronal cells by blocking the pro-inflammatory signaling.This work not only helps to elucidate the mechanism of ceria-nanoparticle-mediated neuroprotection but also provides anew strategy to rebalance the immuno-environment by switching the equilibrium of the phenotypic activation of microglia.

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“…These results suggest that MeNPs suppressed hydroxyl radical formation by KCs. Unlike ceria-based nanoparticles displaying high cytotoxicity [18], MeNPs with low cytotoxicity might be promising hydroxyl radical scavengers.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles

Hayashi

Tokuda

Sakamoto

2018

IJMS

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Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.

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Ceria–Zirconia Nanoparticles as an Enhanced Multi‐Antioxidant for Sepsis Treatment

Cited by 281 publications

References 32 publications

An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Custom‐Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles

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