Cerium-doped bioactive glass-loaded chitosan/polyethylene oxide nanofiber with elevated antibacterial properties as a potential wound dressing

Saatchi, Alireza; Arani, Ahmad Razaghian; Moghanian, Amirhossein; Mozafari, Masoud

doi:10.1016/j.ceramint.2020.12.078

Cited by 50 publications

(22 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, it has been shown that the incorporation of pure or ceramic NPs such as Ag [43,44], TiO 2 [45], CeO 2 [46,47] and ZnO [48][49][50] into natural polymer matrices, during the processing of hybrid natural nanofibers, can improve the wound healing process and be used as dressing materials. In particular, it has been established that the addition of Cu NPs into the PVA-CTS system improves the rate of wound closure.…”

Section: Introductionmentioning

confidence: 99%

In Situ Growth of Silver Nanoparticles on Chitosan Matrix for the Synthesis of Hybrid Electrospun Fibers: Analysis of Microstructural and Mechanical Properties

et al. 2022

View full text Add to dashboard Cite

A viable alternative for the next generation of wound dressings is the preparation of electrospun fibers from biodegradable polymers in combination with inorganic nanoparticles. A poly(vinyl alcohol)-chitosan-silver nanoparticles (PVA-CTS-Ag NPs) system has been developed for antimicrobial and wound healing applications. Here, the preparation of PVA-CTS-Ag electrospun fibers using a two-step process is reported in order to analyze changes in the microstructural, mechanical, and antibacterial properties and confirm their potential application in the biomedical field. The Ag nanoparticles were well-dispersed into the chitosan matrix and their cubic structure after the electrospinning process was also retained. The Ag NPs displayed an average diameter of ~33 nm into the CTS matrix, while the size increased up to 213 nm in the PVA-CTS-Ag(NPs) fibers. It was observed that strong chemical interactions exist between organic (CTS) and inorganic phases through nitrogenous groups and the oxygen of the glycosidic bonds. A defect-free morphology was obtained in the PVA-CTS-Ag NPs final fibers with an important enhancement of the mechanical properties as well as of the antibacterial activity compared with pure PVA-CTS electrospun fibers. The results of antibacterial activity against E. coli and S. aureus confirmed that PVA-CTS-Ag(NPs) fibers can be potentially used as a material for biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

In Situ Growth of Silver Nanoparticles on Chitosan Matrix for the Synthesis of Hybrid Electrospun Fibers: Analysis of Microstructural and Mechanical Properties

et al. 2022

View full text Add to dashboard Cite

show abstract

“…By further increasing the ratio, the effects of Ce-BG affinity on the above are reduced. In addition, chitosan/PEO scaffolds containing Ce-BG had mechanical properties very close to those of the skin, and the results showed that they were only 20% shorter than the required length when breaking skin tissue scaffolds, which increased in length by 28.6% when broken [32].…”

Section: New Advances In Wound Dressing Of Bioactive Nanofibersmentioning

confidence: 93%

Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review

et al. 2021

View full text Add to dashboard Cite

Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.

show abstract

“…A. Saatchi et al fabricated nanofibrous cerium doped bioactive glass (Ce-BG) incorporated CH-PEO composite scaffolds with varying content of Ce-BG up to 40% (w/w). 50 The authors found that incorporation of Ce-BG nanoparticles up to 10-20% (w/w) into the electrospun scaffolds, the tensile strength and tensile modulus of the electrospun scaffolds were increased. On the other hand, Ce-BG content greater than 20% (w/w) in electrospun scaffold led to a decrease in the tensile strength and tensile modulus, possibly owing to the agglomeration of Ce-BG nanoparticles into the polymer matrix.…”

Section: Mechanical Properties Of Scaffoldsmentioning

confidence: 99%

Enhancing physicochemical, mechanical, and bioactive performances of monetite nanoparticles reinforced chitosan‐PEO electrospun scaffold for bone tissue engineering

Singh

Mishra

Gupta

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

In the current work, monetite (DCPA) nanoparticles incorporated chitosan (CH)‐based composite was prepared using by electrospinning technique. A smooth and defect‐free fibrous matrix with an average fiber diameter in the range between 311 ± 13 to 380 ± 28 nm was obtained for 5 wt% (CH‐DCPA5) and 7 wt% DCPA (CH‐DCPA7) containing electrospun scaffolds. The results indicated that the addition of 7 wt% DCPA nanoparticles to chitosan caused an increase in the tensile strength of scaffolds from 6.2 to 12.34 MPa. A slow degradation rate (~37% in 28 days) indicates its suitability for bone tissue regeneration. A study on the biomineralization capability of the electrospun scaffolds after their immersion in simulated body fluid in vitro revealed that the addition of DCPA strongly promoted the deposition of the apatite layer onto electrospun nanofibrous scaffolds. The culture of MG‐63 osteoblast cells on the scaffolds demonstrated that the incorporation of DCPA nanoparticles into the chitosan polymeric matrix helped in the adhesion, spreading, and migration of cells. CH‐DCPA5 and CH‐DCPA7 scaffolds exhibited a higher capacity to proliferate osteoblast cell lines as compared to pure CH scaffold as confirmed by MTT assay and qualitative cell viability analysis from fluorescence microscopy. Immunocytochemistry analysis for osteocalcin expression revealed a higher capacity of DCPA‐containing scaffolds to differentiate MG‐63 cells into bone lineage as compared to pure chitosan scaffolds. DCPA incorporation into chitosan also resulted in MG‐63 cultured on to it to elicit higher alkaline phosphatase activity suggesting the highest capacity of CH‐DCPA7 to differentiate MG 63 cell line among all the scaffolds studied here. The results indicated superior osteogenic properties of DCPA nanoparticle reinforced chitosan matrix for use in BTE in the form of nanofibrous scaffolds.

show abstract

Cerium-doped bioactive glass-loaded chitosan/polyethylene oxide nanofiber with elevated antibacterial properties as a potential wound dressing

Cited by 50 publications

References 58 publications

In Situ Growth of Silver Nanoparticles on Chitosan Matrix for the Synthesis of Hybrid Electrospun Fibers: Analysis of Microstructural and Mechanical Properties

In Situ Growth of Silver Nanoparticles on Chitosan Matrix for the Synthesis of Hybrid Electrospun Fibers: Analysis of Microstructural and Mechanical Properties

Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review

Enhancing physicochemical, mechanical, and bioactive performances of monetite nanoparticles reinforced chitosan‐PEO electrospun scaffold for bone tissue engineering

Contact Info

Product

Resources

About