Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study

Sack-Zschauer, Maren; Bader, Sina; Brenneisen, Peter

doi:10.4172/2157-7439.1000474

Cited by 10 publications

(7 citation statements)

References 70 publications

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“…Results showed that CeO-NPs induced apoptosis in cancer cells but not in normal tissues and reduced tumor growth and invasiveness in a xenograft animal model in vivo [20]. CeO-NPs were also effective in killing high-grade astrocytoma cells but not normal endothelial cells, which were inhibited in their migratory capacity, suggesting that tumor angiogenesis might also be effectively targeted by this treatment [21]. In addition, CeO-NPs were also used in combination with the anticancer compound doxorubicin, which exerts its cytotoxic effect in part by inducing ROS [12].…”

Section: Modulation Of Redox Homeostasis By Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

et al. 2020

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Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and cancer cells are strongly addicted to the increased activity of scavenging pathways to maintain ROS below levels that produce macromolecular damage and engage cell death pathways. Consistent with this notion, tumor cells are more vulnerable than their normal counterparts to pharmacological treatments that increase ROS production and inhibit ROS scavenging. In the present review, we discuss the recent advances in the development of integrated anticancer therapies based on nanoparticles engineered to kill cancer cells by raising their ROS setpoint. We also examine nanoparticles engineered to exploit the metabolic and redox alterations of cancer cells to promote site-specific drug delivery to cancer cells, thus maximizing anticancer efficacy while minimizing undesired side effects on normal tissues.

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Section: Modulation Of Redox Homeostasis By Nanoparticlesmentioning

confidence: 99%

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

et al. 2020

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“…CeO‐NPs were found to cause apoptosis in cancer cells but not in healthy tissues, and to inhibit the growth and metastatic spread of cancer in an animal model of xenografts in vivo (Alili et al, 2013). CeO‐NPs effectively inhibited the motility of normal endothelial cells while damaging elevated astrocytoma cells, suggesting that this drug may also be helpful in halting tumor angiogenesis (Zschauer et al, 2017). CeO‐NPs improved the anticancer effects of doxorubicin while dramatically lowering the adverse effects of this medicine on normal cells, including myocardiocytes, in line with its dual impact on ROS in cancer vs. normal tissues.…”

Section: Mechanistic Framework Of Ne‐pdtmentioning

confidence: 99%

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

Rajan,

Chandran,

Abrahamse

2024

WIREs Nanomed Nanobiotechnol

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Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a transformative force in cancer treatment, particularly through nano‐enabled photodynamic therapy (NE‐PDT), which leverages precise and targeted interventions. NE‐PDT capitalizes on photosensitizers activated by light to generate reactive oxygen species (ROS) that initiate apoptotic pathways in cancer cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, and ROS production within tumors. This review dissects NE‐PDT's mechanistic framework, showcasing its potential to harness apoptosis as a potent tool in cancer therapy. Furthermore, the review explores the synergy between NE‐PDT and complementary treatments like chemotherapy, immunotherapy, and targeted therapies, highlighting the potential to amplify apoptotic responses, enhance immune recognition of cancer cells, and inhibit resistance mechanisms. Preclinical and clinical advancements in NE‐PDT demonstrate its efficacy across various cancer types. Challenges in translating NE‐PDT into clinical practice are also addressed, emphasizing the need for optimizing nanoparticle design, refining dosimetry, and ensuring long‐term safety. Ultimately, NE‐PDT represents a promising approach in cancer therapy, utilizing the intricate mechanisms of apoptosis to address therapeutic hurdles. The review underscores the importance of understanding the interplay between nanoparticles, ROS generation, and apoptotic pathways, contributing to a deeper comprehension of cancer biology and novel therapeutic strategies. As interdisciplinary collaborations continue to thrive, NE‐PDT offers hope for effective and targeted cancer interventions, where apoptosis manipulation becomes central to conquering cancer.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…Some previous reports show that CeO 2 has different results to different cells due to different intracellular environments such as the concentration of intercellular hydroxyl radicals [15,[58][59][60]. For example, Sack-Zschauer et al found that cerium oxide nanoparticles have a cytotoxicity to astrocytoma cells while showing no cytotoxicity towards endothelial cells [61]. Khaligh et al synthesized two materials, which are toxic to human HT-29 colon cancer cells line but not to human foreskin fibroblast cells line [62].…”

Section: Effect Of Materials Concentration On Antioxidant Activitymentioning

confidence: 99%

A simple method for the preparation of CeO₂ with high antioxidant activity and wide application range

Guo

Zhao

et al. 2022

Nanotechnology

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Cerium oxide (CeO2) is a well-known antioxidant with the ability to scavenge reactive oxygen species due to its unique electronic structure and chemical properties. Although many methods to enhance the antioxidant activity of CeO2 have been reported, its antioxidant activity is still not high enough, and some enhancement effects are limited by the material concentration. There are also some CeO2 obtained with high antioxidant activity at high concentrations, which is not conducive to the application of biomedicine. Therefore, it is urgent to obtain CeO2 material with low cell cytotoxicity, high antioxidant activity and wide application range. In this work, rod-like metal organic framework derived CeO2 (CeO2-MOF) was prepared by a simple method. Compared with the CeO2 nanorods prepared by hydrothermal method, it shows better antioxidant activity compared with the CeO2 nanorods prepared by hydrothermal method. Moreover, the advantage of CeO2-MOF’s antioxidant activity is not affected by the hydroxyl radical and material concentrations The reason why CeO2-MOF has higher antioxidant activity should be attributed to its higher Ce3+ content and larger specific surface area. In addition, CeO2-MOF also exhibits low cytotoxicity to HeLa cells and PC 12 cells in vitro. The strategy of using MOF as a structural and compositional material to create CeO2 provides a new method to explore highly efficient and biocompatible CeO2 for practical applications.

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Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study

Cited by 10 publications

References 70 publications

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

A simple method for the preparation of CeO₂ with high antioxidant activity and wide application range

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Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study

Cited by 10 publications

References 70 publications

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells

Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

A simple method for the preparation of CeO2 with high antioxidant activity and wide application range

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Resources

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A simple method for the preparation of CeO₂ with high antioxidant activity and wide application range