Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis

Oró, Denise; Yudina, Tetyana; Fernández‐Varo, Guillermo; Casals, Eudald; Reichenbach, Vedrana; Casals, Gregori; Presa, Bernardino González de la; Sandalinas, Silvia; Carvajal, Silvia; Puntes, Víctor; Jiménez, Wladimiro

doi:10.1016/j.jhep.2015.10.020

Cited by 179 publications

(153 citation statements)

References 26 publications

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“…In the past few years, nanoceria already has been widely used in the aspects of free-radical scavenger [5,6], radiation protection [7], ischemic stroke [8], cancer biomarker [9], anti-inflammatory [10], antioxidant drug [11], cardiovascular Figure 1: Reactive species induced oxidation stress damage to the human health.…”

Section: Introductionmentioning

confidence: 99%

Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

Shi

Shen

et al. 2018

Journal of Nanomaterials

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As a new antioxidant, nanoceria is of significant importance in applications of medical and biological fields. In comparison with conventional organic antioxidants, nanoceria has multienzyme mimetic activity by Ce 4+ /Ce 3+ redox cycle. This unique regenerative/autocatalytic property has been widely used in the aspects of free-radical scavenger, radiation protection, oxidativestress-related disease, drug delivery, biosensor, tissue engineering, cancer biomarker, and anti-inflammatory. This paper reviews the latest breakthrough of nanoceria as an antioxidant in applications of medical and biological fields on the base of the authors' research works on resistance to oxidation and cytotoxicity. The challenges of nanoceria encountered in applications in medical and biological fields are commented as well.

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Section: Introductionmentioning

confidence: 99%

Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

Shi

Shen

et al. 2018

Journal of Nanomaterials

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“…Furthermore, several studies have shown that CeO 2 nanoparticles can be used to treat stroke [18], ovarian cancer [19], cardiomyopathy [20], sepsis [21] and obesity [22]. More recently, Oro et al, have shown that CeO 2 nanoparticles attenuate steatosis and portal hypertension in rats with hepatic fibrosis [23]. Whether CeO 2 nanoparticles can be used to attenuate hepatic injury caused by IR is not known.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats

Manne¹,

Arvapalli

Graffeo³

et al. 2017

Cell Physiol Biochem

555

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Background: Hepatic ischemia reperfusion is one the main causes for graft failure following transplantation. Although, the molecular events that lead to hepatic failure following ischemia reperfusion (IR) are diverse and complex, previous studies have shown that excessive formation of reactive oxygen species (ROS) are responsible for hepatic IR injury. Cerium oxide (CeO 2 ) nanoparticles have been previously shown to act as an anti-oxidant and anti-inflammatory agent. Here, we evaluated the protective effects of CeO 2 nanoparticles on hepatic ischemia reperfusion injury. Methods: Male Sprague Dawley rats were randomly assigned to one of the four groups: Control, CeO 2 nanoparticle only, hepatic ischemia reperfusion (IR) group and hepatic ischemia reperfusion (IR) plus CeO 2 nanoparticle group (IR+ CeO 2 ). Partial warm hepatic ischemia was induced in left lateral and median lobes for 1h, followed by 6h of reperfusion. Animals were sacrificed after 6h of reperfusion and blood and tissue samples were collected and processed for various biochemical experiments. Results: Prophylactic treatment with CeO 2 nanoparticles (0.5mg/kg i.v (IR+CeO 2 group)) 1 hour prior to hepatic ischemia and subsequent reperfusion injury lead to a decrease in serum levels of alanine aminotransaminase and lactate dehydrogenase at 6 hours after reperfusion. These changes were accompanied by significant decrease in hepatocyte necrosis along with reduction in several serum inflammatory markers such as macrophage derived chemokine, macrophage inflammatory protein-2, KC/GRO, myoglobin and plasminogen activator inhibitor-1. However, immunoblotting demonstrated no significant changes in the levels of apoptosis related protein markers such as bax, bcl2 and caspase 3 in IR and IR+ CeO2 groups at 6 hours suggesting necrosis as the main pathway for hepatocyte death. Conclusion: Taken together, these data suggest that CeO 2 nanoparticles attenuate IR induced cell death and can be used as a prophylactic agent to prevent hepatic injury associated with graft failure.Room 315,

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“…Cerium oxide (CeO 2 ) was used in nanotherapeutics to decrease mediators of chronic inflammation 87. Reactive oxygen species (ROS) and reactive nitrogen species are key signaling molecules that play an important role in the progression of RA 88.…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 95%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis

Cited by 179 publications

References 26 publications

Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

Hot Topics and Challenges of Regenerative Nanoceria in Application of Antioxidant Therapy

Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

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