Certain <i>Listeria monocytogenes</i> plasmids contribute to increased UVC ultraviolet light stress

Anast, Justin M.; Schmitz‐Esser, Stephan

doi:10.1093/femsle/fnab123

Cited by 7 publications

(6 citation statements)

References 49 publications

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“…Plasmids in L. monocytogenes could benefit the survival and enhance the virulence of LM populations (37,38). The 57kb plasmid was found in ST121 strains in this study, and existed in diverse host strains in many countries between 1994 and 2020 , which codes many functional and uncharacterized proteins, including UvrX for resistance to UV-induced damage, GbuC for resistance to osmosis, Npx for resistance to oxidative stress, type II TA system for plasmid maintenance, and transposases facilitating genomic islands across diverse bacteria (38)(39)(40). This was not certified by peer review) is the author/funder.…”

Section: Discussionmentioning

confidence: 78%

Insight into the genetic diversity, resistance, and virulence ofListeriafrom the marine environment: reveal the risk of hypervirulent isolates

Mao

Wang

et al. 2023

Preprint

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Listeria monocytogenesis a major human foodborne pathogen and a ubiquitous environmental saprophyte. In this study, we investigated the prevalence and characteristics ofListeria spp.from beach sand in the coastal environment. Three differentListeria spp.,Listeria monocytogenes(n=16),Listeria fleishmanii(n=7), andListeria aquatica(n=3) were isolated from 769 beach sand samples and demonstrated diverse biofilm forming capacity. TheL. monocytogenesisolates belonged to four distinct sequence types (ST87, ST121, ST35, and ST85) and contained the majority of virulence genes, some isolates were hypervirulent clones or had close phylogenetic relatedness with clinical cases. The ST87 isolates showed higher ability of biofilm formation in seawater than other STs strains. As a reservoir of microbes from marine environments and human/animal excrement, coastal sand would play an important role in the spread ofL. monocytogenesand is an environmental risk for human listeriosis.

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Section: Discussionmentioning

confidence: 78%

Insight into the genetic diversity, resistance, and virulence ofListeriafrom the marine environment: reveal the risk of hypervirulent isolates

Mao

Wang

et al. 2023

Preprint

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“…In this study, LM was the most resistant bacteria to far-UVC light ( Table 1 ). One possible explanation is the presence of specific plasmids that increase survival against stress induced by far-UVC light [ 35 ]. Specifically, the uvrX plasmid encodes a DNA polymerase associated with binding to repair DNA damaged by UV light [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

Lorenzo-Leal,

Tam,

Kheyrandish

et al. 2023

BioMed Research International

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Ultraviolet (UV) light is an effective disinfection technology, able to inactivate a wide range of microorganisms, including bacteria and fungi. A safer UV wavelength of 222 nm, also known as far-UVC, has been proposed to minimize these harmful effects while retaining the light’s disinfection capability. This study is aimed at exploring the antimicrobial activity of filtered far-UVC (222 nm) on a panel of pathogens commonly found in nosocomial installations. A panel of Gram-positive and Gram-negative bacteria and yeast pathogens was tested. Microorganisms were deposited on a plastic surface, allowing them to dry before exposure to the far-UVC light at a distance of 50 cm. Results showed that far-UVC light successfully inhibits the growth of the tested pathogens, although at different exposure times. In conclusion, the results of this study provide fundamental information to achieve reliable disinfection performance with far-UVC lamps with potential applications in healthcare facilities like hospitals and long-term care homes.

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“…A similar finding was described for the chromosomally encoded gene uvrA , which was shown to be necessary for the bacterial UV stress survival ( Kim et al, 2006 ). Recently, Anast and Schmitz-Esser (2021) identified several L. monocytogenes plasmids that confer increased UV stress tolerance, although their precise role in this phenomenon needs further investigations.…”

Section: Adverse Environmental Conditions and Survival Of L...mentioning

confidence: 99%

Listeria monocytogenes – How This Pathogen Survives in Food-Production Environments?

2022

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The foodborne pathogen Listeria monocytogenes is the causative agent of human listeriosis, a severe disease, especially dangerous for the elderly, pregnant women, and newborns. Although this infection is comparatively rare, it is often associated with a significant mortality rate of 20–30% worldwide. Therefore, this microorganism has an important impact on food safety. L. monocytogenes can adapt, survive and even grow over a wide range of food production environmental stress conditions such as temperatures, low and high pH, high salt concentration, ultraviolet lights, presence of biocides and heavy metals. Furthermore, this bacterium is also able to form biofilm structures on a variety of surfaces in food production environments which makes it difficult to remove and allows it to persist for a long time. This increases the risk of contamination of food production facilities and finally foods. The present review focuses on the key issues related to the molecular mechanisms of the pathogen survival and adaptation to adverse environmental conditions. Knowledge and understanding of the L. monocytogenes adaptation approaches to environmental stress factors will have a significant influence on the development of new, efficient, and cost-effective methods of the pathogen control in the food industry, which is critical to ensure food production safety.

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Certain Listeria monocytogenes plasmids contribute to increased UVC ultraviolet light stress

Cited by 7 publications

References 49 publications

Insight into the genetic diversity, resistance, and virulence ofListeriafrom the marine environment: reveal the risk of hypervirulent isolates

Insight into the genetic diversity, resistance, and virulence ofListeriafrom the marine environment: reveal the risk of hypervirulent isolates

Antimicrobial Activity of Filtered Far‐UVC Light (222 nm) against Different Pathogens

Listeria monocytogenes – How This Pathogen Survives in Food-Production Environments?

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