In this article, we obtain certain novel reverse Hölder- and Minkowski-type inequalities for modified unified generalized fractional integral operators (FIOs) with extended unified Mittag–Leffler functions (MLFs). The predominant results of this article generalize and extend the existing fractional Hölder- and Minkowski-type integral inequalities in the literature. As applications, the reverse versions of weighted Radon-, Jensen- and power mean-type inequalities for modified unified generalized FIOs with extended unified MLFs are also investigated.