Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determinations

Versieck, Jacques; Vanballenberghe, L; Kessel, Antoine de; Hoste, J.; Wallaeys, B.; Vandenhaute, J.; Baeck, Nicole; Steyaert, Herman; Byrne, A. R.; Sunderman, F. William

doi:10.1016/s0003-2670(00)86346-1

Cited by 151 publications

(24 citation statements)

References 13 publications

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“…The second-generation reference serum prepared at the University of Ghent [19]has certified concentrations for Cs and Rb and provides an indicative value for Li. The concentrations of Li, Rb, and Cs in a reference water have been determined to check the analytical procedure for these elements in dialysis fluids.…”

Section: Discussionmentioning

confidence: 99%

“…For quality control, a serum reference material prepared by Versieck et al [19](University of Ghent) and a water reference material (SRM 1643d; National Institute of Standards and Testing, Gaithersburg, Md., USA) were analyzed for Li, Rb, and Cs. Test solutions for the two electrolytes Na and K (Stat Profile 10 – Ultra Control; Nova Biomedical, Waltham, Mass., USA), available at three different concentrations, were used to test the performance of the analyzers prior to every series of measurements with all three levels.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Exchange of Alkali Trace Elements in Hemodialysis Patients:A Comparison with Na+ and K+

Krachler

Scharfetter

Wirnsberger

1999

Nephron

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Background: In the past, nephrologists have been troubled by electrolyte disturbances and consequently focused their attention on the importance of maintaining the concentrations of electrolytes within the normal range. However, information about the potential role of trace elements in chronic renal failure is scarce. Methods: During hemodialysis sessions, the concentrations of the five alkali metal cations lithium (Li), sodium (Na), potassium (K), rubidium (Rb), and cesium (Cs) have been determined in plasma and dialysis fluids of chronic hemodialysis patients by inductively coupled plasma mass spectrometry (Li, Rb, Cs) and by ion-sensitive electrodes (Na, K). Strict quality control schemes were applied to all analytical procedures to ensure accuracy and precision of the results. Results: The plasma concentrations of the elements Li, Cs, Rb, and K distinctly decreased to 29, 50, 69, and 71%, respectively, of their initial values during hemodialysis. Simultaneously, the concentrations of these elements in dialysis fluids at the outlet of the dialyzer increased approximately 13-fold for Rb, 11-fold for Li, 3-fold for Cs, and 2-fold for K as compared with the inlet values. The concentrations of Na in plasma and dialysis fluids were almost identical and did not change during hemodialysis. Conclusions: Li, Rb, and Cs were depleted in hemodialysis patients, although the plasma concentrations of these trace elements still remained within the reference ranges for healthy adults. Consequently, further studies are needed to elucidate the clinical importance and long-term effects of these trace element imbalances – for example, CNS disturbances associated with diminished concentrations of Rb – in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Exchange of Alkali Trace Elements in Hemodialysis Patients:A Comparison with Na+ and K+

Krachler

Scharfetter

Wirnsberger

1999

Nephron

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“…The methodology applied is described elsewhere (29). The analytical procedure was checked using Gent second-generation freeze-dried human serum reference material (30), which was analyzed together in each sample batch. Differences in the certified value were below 5% for Fe and Se and below 10% for Cu, Zn, K, and Ca.…”

Section: Elemental Analysismentioning

confidence: 99%

Systemic Markers of the Redox Balance and Apolipoprotein E Polymorphism in Atherosclerosis: The Relevance for an Integrated Study

Lopes

Napoleão

Pinheiro

et al. 2006

BTER

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H u m a n a J o u r n a l s . c o mS e a r c h , R e a d a n d D o w n l o a d Featured in this issue: ABSTRACTProspective studies have demonstrated that an imbalance between oxidative damage and antioxidative protection can play a role in the development and progression of atherosclerosis. Also, genotypes with the apolipoprotein E ε4 allele have been associated with an increase risk for this pathology. Based on this knowledge, the aim of this study was to evaluate indicators of the redox balance, trace elements, and apolipoprotein E allelic profile in subjects from the Lisbon population with clinically stable atherosclerosis, at risk for atherosclerotic events, and in healthy subjects for comparison. The activities of superoxide dismutase in erythrocytes and glutathione peroxidase in whole blood, plasma total thiols, and serum ceruloplasmin were kept unchanged among the three groups. Serum α-tocopherol was increased in atherosclerotic patients. *Author to whom all correspondence and reprint requests should be addressed.lipid and protein oxidative damage, respectively, reached their highest values in risk subjects. The concentrations of potassium and calcium, in plasma and in blood cells, were slightly elevated in patients and might reflect an electrolytic imbalance. Regarding the apolipoprotein E polymorphism, atherosclerotic patients had an increased incidence of the high-risk genotypes for atherogenesis (ε3/ε4 and ε4/ε4). A multivariate model applied to the general population using most of the parameters clearly separated the three groups at study (i.e., the healthy group from the steady-state group of risk disease and from the atherosclerotic one). As shown by us, the usefulness of biochemical and complementary genetic markers is warranted for a better knowledge on atherosclerosis molecular basis.

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“…Zinc was determined by flame atomic absorption spectroscopy (Perkin Elmer 2100 apparatus) after dilution in 0.1 N HC1 [32]. Accuracy of the procedure was established by analysis of a reference material manufactured by J. Versieck, Belgium [33]. Results are expressed as mean concentrations in each subgroup-+ standard deviation (SD), in gg zinc/dL serum, and compared by the Student's t-test.…”

Section: Sacrifice Of Animals and Analytical Determinationsmentioning

confidence: 99%

Effects of acute and chronic prednisolone treatment on serum zinc levels in rats with adjuvant arthritis

et al. 1991

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Several studies in animals and humans have independently demonstrated that zinc metabolism is significantly affected either by inflammation or by glucocorticoid administration. The relative importance of these two factors was assessed in this study by the investigation of the effects on serum zinc concentrations of acute and chronic prednisolone treatments in adjuvant arthritis rats and in healthy controls animals. Acute steroid administration (3 mg/kg, i.p.) caused a rapid drop in serum zinc followed by a quick recovery, regardless to the fact that these concentrations were normal (healthy animals) or already reduced by the inflammatory process. However, the modification occurred faster in inflamed animals. Chronic steroid administration (0.58 to 0.78 mg/kg/day during 1 to 4 weeks) had a more complex effect. A previous experiment in healthy rats demonstrated that such a treatment only induced a slight decrease in serum zinc. In adjuvant arthritis animals, the early steroid treatment of the induced process promoted a further decrease in serum zinc level while a delayed treatment did not result in additional changes.

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Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determinations

Cited by 151 publications

References 13 publications

Exchange of Alkali Trace Elements in Hemodialysis Patients:A Comparison with Na<sup>+</sup> and K<sup>+</sup>

Exchange of Alkali Trace Elements in Hemodialysis Patients:A Comparison with Na<sup>+</sup> and K<sup>+</sup>

Systemic Markers of the Redox Balance and Apolipoprotein E Polymorphism in Atherosclerosis: The Relevance for an Integrated Study

Effects of acute and chronic prednisolone treatment on serum zinc levels in rats with adjuvant arthritis

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