Ceruminolytic Effects of Docusate Sodium: A Randomized, Controlled Trial

Singer, Adam J.; Sauris, Ed; Viccellio, Asa

doi:10.1067/mem.2000.109166

“…a Control arm with no treatment not included. 46 Whatley and colleagues, 47 Singer and colleagues, 49 Pavlidis and Pickering, 42 Amjad and Scheer, 51 Lyndon and colleagues, 45 Saloranta and colleagues a , 58 Roland and colleagues, 62 Fraser, 60 Dubow, the arms in the trial was a self-syringing group and this may also explain the higher number of AEs in the study. If this study was excluded then the probability of minor AEs would fall to 3.05% for the remaining included studies.…”

Section: Minor Adverse Events From Drops and Irrigationmentioning

confidence: 95%

“…With only 4 out of 14 studies reporting baseline characteristics, 42,47,49,50 it is also not possible to judge the similarities between the treatment groups at baseline for the majority of the studies. Four studies were judged adequate for the description of missing values, 45,47,49,52 but none of the studies reported an adequate intention-to-treat (ITT) analysis.…”

Section: Studies In Primary Care Settingsmentioning

confidence: 99%

“…Study sample sizes were typically small, varying from 36 participants 45 to 237 participants, 63 and only a few studies reported undertaking a sample size calculation (7 out of 24 studies 45,47,49,52,53,56,63 ). In some studies the overall population sample size was not reported, rather the numbers of ears were presented.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

“…A number of studies pre-date RCT reporting guidelines, but this may also reflect set word limits for some of the publications. Only three RCTs 47,49,52 were assessed as adequate for their randomisation procedure, with one assessed as partially meeting this criteria. 42 For several studies the method was judged inadequate, 46,51,53 but for the majority 41,44,45,48,50 it was not possible to judge due to a distinct lack of information.…”

Section: Studies In Primary Care Settingsmentioning

confidence: 99%

See 2 more Smart Citations

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

Clegg

¹

,

Loveman²,

Gospodarevskaya³

et al. 2010

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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“…These trials fell into three categories: studies undertaken in primary care (14 studies [41][42][43][44][45][46][47][48][49][50][51][52][53][54] ), studies undertaken in secondary care (eight studies 4,[54][55][56][57][58][59][60] ), and studies of self-care or those undertaken in other care settings (four studies [61][62][63][64] ). Where the setting was in emergency care this has been grouped under primary care in the present review because it was assumed that this was the first point of contact with a health professional.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

2010

Clinical Governance: An International Journal

0

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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Randomized, Placebo-Controlled Evaluation of Cerumenex and Murine Earwax Removal Products

Roland¹,

Eaton

²

,

Gross

³

et al. 2004

Arch Otolaryngol Head Neck Surg

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Participants: From among 230 volunteers screened, 74 subjects (age, 22-66 [mean, 45] years) were enrolled in the study. Participants had baseline occlusion levels of mild (n=10), moderate (n=26), or complete (n=38) impairment of tympanic membrane visualization.Interventions: Subjects were randomly assigned to 1 of 3 treatments: Cerumenex (10% triethanolamine polypeptide oleate-condensate), Murine (6.5% carbamide peroxide), and a placebo, BSS Sterile Irrigating Solution (Alcon Laboratories Inc, Ft Worth, Tex). The test medication was instilled into 1 occluded ear for up to two 15-minute applications. Following the treatment, the subject's ear was irrigated with 50 mL of lukewarm water delivered at low pressure via a WaterPik irrigator equipped with a Grossan irrigator tip.Main Outcome Measure: The degree of occlusion, measured against a previously established 4-point scale, was assessed and recorded at baseline and after each instillation and irrigation procedure.Results: Neither Cerumenex nor Murine was superior to saline placebo. By the end of treatment, 29.2%, 15.4%, and 41.7% of subjects treated with Cerumenex, Murine, and placebo, respectively, experienced resolution of cerumen occlusion. These values were not statistically significantly different from one another. Conclusion:The currently marketed ceruminolytic products, Cerumenex and Murine, are no more effective than a saline placebo in removing earwax.

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Ceruminolytic Effects of Docusate Sodium: A Randomized, Controlled Trial

Cited by 47 publications

References 8 publications

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

Randomized, Placebo-Controlled Evaluation of Cerumenex and Murine Earwax Removal Products

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