Ceruminous gland adenocarcinoma.A light and electron microscopic study

Abstract

Tumors of ceruminous gland origin in the external auditory canal are rare in man. A case is described in which such a tumor presented as an invasive vascular temporal bone neoplasm, mimicking a glomus jugulare tumor. Light and electron microscopic study of this tumor confirmed a diagnosis of ceruminous gland adenocarcinoma. Tumors of ceruminous gland origin appear to have a distinctive clinical behavior by virtue of their unique anatomical location in the external auditory canal. Our experience with this case establishes another clinical picture characterizing the histologic type of ceruminoma designated as a ceruminous gland adenocarcinoma. We feel that the generic term "ceruminoma," with its implied histologic subgroups, is useful to the clinician when he encounters a tumor arising from the modified sweat glands of the external auditory canal.

Low‐Grade adenocarcinoma of probable endolymphatic sac origin. A clinicopathologic study of 20 cases

“…The polyclonal antibodies used were rabbit antisera to S-100 protein (dilution 1 :20; Dako Laboratories, Santa Barbara, CA) and glial fibrillary acidic protein (GFAP) (dilution 1 :400; Dako Laboratories, Santa Barbara, CA). Mouse monoclonal antisera to AE1/3 ker- No. 11 ENDOLYMPHATIC ADENOCARCINOMA * Heflner 2293 atin proteins (dilution 150; Boehringer Mannheim Biochemicals, Indianapolis, IN), leukocyte 7 antigen (dilution 1 :8; Leu-7, Becton-Dickinson, Mountain View, CA), and synaptophysin (dilution 150; Dako Laboratories, Santa Barbara, CA) were used.…”

A unique case of apocrine carcinoma on the male pubic skin: Histopathologic and ultrastructural observations

“…Apocrine adenocarcinomas of the skin are rare (1)(2)(3)(4)(5)(6). They occur mainly in the axillae (1)(2)(3)(4)(5), but occasionally also in other areas where apocrine or modified apocrine glands normally are present (7)(8)(9), and rarely even in areas usually lacking these glands (6). Apocrine carcinomas can also arise in the breast (10)(11)(12)(13).…”

Ceruminous Gland Carcinomas: A Clinicopathologic and Immunophenotypic Study of 17 Cases

“…The endolymphatic sac tumor [36], neuroendocrine adenoma of the middle ear [37], middle ear adenocarcinoma, and ceruminous adenoma [35] have been much more completely described and refined. Critical review of many of the earlier case reports of ceruminous neoplasms allow for a more accurate placement in different tumor categories [2, 8, 15, 19–28]. Careful review of the remaining cases, most of which are single case reports or limited case series, further narrows the number of cases available for review (see Table 2) [4, 5, 10, 12, 14, 16–18, 29–32, 38–66].…”

“…However, many cases were excluded if the lesion arose primarily in the middle ear, endolymphatic sac region, or represented a neuroendocrine adenoma (middle ear adenoma), or a primary salivary gland (parotid) tumor or extended into the ear from a tumor “centered” in the oral cavity, nasal cavity, nasopharynx, sinuses, or soft tissues of the neck were excluded [2, 8, 15, 19–28]. …”

“…While common in other animals [1], tumors of this type are rare in humans and therefore are seldom seen by general surgical pathologists [2, 3]. In fact, glandular external auditory canal tumors represent 0.00025% of all cases at one large referral institution [4], and represented 2.4% of all ear neoplasms at our referral institution.…”