Cervical adenocarcinoma: Moving towards better prevention

Seoud, Muhieddine; Tjalma, Wiebren A.A.; Ronsse, Veerle

doi:10.1016/j.vaccine.2011.09.115

Cited by 61 publications

(52 citation statements)

References 113 publications

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“…Our results show that the ratio of histological types (18% adenocarcinoma vs 82% squamous cell carcinoma) is in agreement with published data15 with no apparent difference across age of patients, particularly when the 2 age clusters (25‐50 years and 51‐80 years) were compared (Figs. 1 and 3).…”

Section: Discussionsupporting

confidence: 92%

Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence

Al-Harbi

Judia

Khoja

et al. 2017

Cancer

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BACKGROUNDCervical cancer is a predominantly human papillomavirus (HPV)‐driven disease worldwide. However, its incidence is unexplainably low in western Asia, including Saudi Arabia. Using this paradigm, we investigated the role of HPV infection rate and host genetic predisposition in TP53 G72C single nucleotide polymorphism (SNP) presumed to affect cancer incidence.METHODSPatients treated between 1990 and 2012 were reviewed, and a series of 232 invasive cervical cancer cases were studied and compared with 313 matched controls without cancer. SNP was genotyped by way of direct sequencing. HPV linear array analysis was used to detect and genotype HPV in tumor samples.RESULTSThe incidence of cervical cancer revealed bimodal peaks at 42.5 years, with a slighter rebound at 60.8 years. Among all cases, 77% were HPV‐positive and 16 HPV genotypes were detected—mostly genotypes 16 (75%) and 18 (9%)—with no difference by age, histology, or geographical region. Although the TP53 G72C genotype was not associated with overall cervical cancer risk, it was significantly associated with HPV positivity (odds ratio, 0.57; 95% confidence interval, 0.36‐0.90; P = .016). Furthermore, the variant C allele was significantly overtransmitted in the population (P < .0003).CONCLUSIONCervical cancer incidence displays bimodal curve peaking at a young age with secondary rebound at older age. The combination of relative low HPV infection and variant TP53 72C allele overtransmission provide a plausible explanation for the low incidence of cervical cancer in our population. Therefore, HPV screening and host SNP genotyping may provide more relevant biomarkers to gauge the risk of developing cervical cancer. Cancer 2017;123:2459–66. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Discussionsupporting

confidence: 92%

Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence

Al-Harbi

Judia

Khoja

et al. 2017

Cancer

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“…This may be a result of the limitations of ADC detection during CC screening: adenocarcinomas are often diagnosed at an advanced disease stage (for a review see ref. 17). The statistical analysis of our data suggested the most predictive set of seven genes (LRRN1, PRICKLE2, VHL, BHLHE40, RBSP3, CGGBP1 and SOX14) that may discriminate SCC and ADC with accuracy (73 ± 6)%.…”

Section: Resultsmentioning

confidence: 73%

Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer

et al. 2013

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“…It is the most common sexually transmitted infection and studies in developed countries suggests that 50-80% of sexually exposed are infected at least once in their life time [4,5]. HPV 16 and 18 are commonest oncogenic type and have been implicated in 60-78% of squamous cancer of the cervix and 72-94% of cervical adenocarcinoma [6]. The prevention and control of cervical cancer had basically emphasized early identification and prompt diagnosis of precancerous lesion of the cervix until the development and introduction of HPV vaccines (cervirax, Gardasil and Gardsil 9) that offers opportunity for primary prevention [7,8].…”

Section: Introductionmentioning

confidence: 99%

Vaccination against Human Papilloma Virus in Adolescent Girls: Mother’s Knowledge, Attitude, Desire and Practice in Nigeria

Ogochukwu¹,

Akabueze²,

Ezeome³

et al. 2017

J Infect Dis Preve

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Cervical adenocarcinoma: Moving towards better prevention

Cited by 61 publications

References 113 publications

Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence

Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence

Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer

Vaccination against Human Papilloma Virus in Adolescent Girls: Mother’s Knowledge, Attitude, Desire and Practice in Nigeria

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