Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes

Hodgson, Anjelica; Park, Kay J.

doi:10.5858/arpa.2018-0259-ra

Cited by 41 publications

(45 citation statements)

References 73 publications

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“…Compared to UEA, GAS has worse outcomes, even at stage I, often presents at high stage, is relatively resistant to standard chemotherapy regimens 3,13 , and often metastasizes to unusual sites such as the omentum, peritoneum, adnexa, liver, brain, and bone 8,13,14 . The propensity for spread to these unusual sites is distinct from UEA, which typically do not metastasize from the pelvis until late in the course of the disease 14 .…”

Section: Discussionmentioning

confidence: 99%

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Gastric‐type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature

et al. 2020

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Objective: Gastric-type endocervical adenocarcinoma (GAS) is an uncommon type of endocervical adenocarcinoma that is not associated with human papillomavirus (HPV) infection. This diagnosis is relatively rare and may portend a worse prognosis than usual-type endocervical adenocarcinoma. Subtle morphologic features make it an underrecognized diagnostic challenge. Study of the cytologic features of individual cases is valuable in order to increase awareness of this entity. Methods: The pathology database of our institution was searched for the diagnosis of GAS and all cytologic and surgical specimens for each patient were reviewed. The original cytologic interpretation was compared to a retrospective central review interpretation. Clinical history and follow up results were obtained from the electronic medical record. Results: Four cases of GAS were identified. The findings on initial cervical cytology varied, with GAS found in both patients with negative cervical cytology and those with atypical glandular cells. Cytologic findings included endocervical cells arranged in three-dimensional clusters and honeycomb sheets with abundant vacuolar cytoplasm, and in two patients, moderate nuclear atypia with irregular nuclear membranes, coarse chromatin, hyperchromatic nuclei, and prominent nucleoli. In one patient, GAS was incidentally discovered via thorough sampling of a cystic lesion in the superior portion of the endocervical canal. Conclusions: GAS is an aggressive HPV-independent type of endocervical adenocarcinoma with subtle morphologic features and, as our study shows, varying clinical presentation. Given the aggressive nature of GAS and the difficulties in initial diagnosis, increased awareness of this entity among pathologists is crucial.

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Section: Discussionmentioning

confidence: 99%

“…This article is protected by copyright. All rights reserved surgical sampling specimens [1][2][3] . The reported cytologic diagnostic features of GAS are subtle and include monolayered and honeycombed sheets of cells with vacuolar or foamy cytoplasm, vesicular nuclei with distinct nucleoli, and minimal to absent mitotic activity 4,5 .…”

Section: Accepted Articlementioning

confidence: 99%

Gastric‐type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature

et al. 2020

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“…Cervical cancer is one of the most common malignancies that arise from the female genital tract, being the third most frequent malignancy to affect women worldwide [4]. Carcinomas pertaining to the uterine cervix can be grossly divided into two categories: squamous cell carcinoma (SCC) that affects the ectocervix and adenocarcinoma (AC) which forms in the endocervix, the part of the cervix that connects the internal with the external cervical os.…”

Section: Discussionmentioning

confidence: 99%

A rare case of gastric-type mucinous endocervical adenocarcinoma in a 59-year-old woman

Mulita

Iliopoulos

Kehagias

2020

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Introduction: Endocervical adenocarcinoma represents 20-25% of the histological types of cervical carcinoma. Gastric-type mucinous adenocarcinoma of the cervix is a rare type of cancer with aggressive behavior. This type of malignancy is not related to high-risk human papillomavirus (HPV). Case report: We report a 59-year-old postmenopausal woman complaining of vaginal bleeding and pelvic pain. Histological analysis of punch biopsy and endocervical curettage revealed possible endocervical mucinous adenocarcinoma, while magnetic resonance imaging (MRI) revealed a 10 × 8 cm sized cervical mass. According to oncologists, the tumor was inoperable, so the patient received 6 cycles of chemotherapeutic agents with carboplatin, paclitaxel and bevacizumab from December 2019 to March 2020. However, chemotherapy had very poor results in this patient, because the mass was increased to 24 cm in a new MRI performed after the end of chemotherapy. Finally, the patient underwent radical surgery. On histopathological examination, the surgical margin was all free from everywhere and the mass was confirmed as a gastric-type mucinous adenocarcinoma of the cervix with low differentiation. Conclusion: It is very important to have an early diagnosis of gastric-type mucinous adenocarcinoma of the cervix, as this tumor is poorly symptomatic and very aggressive. When chemotherapy is not effective, radical surgery may be a solution for better survival.

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“…Cervical cancers for which HPV was never present include a subset of adenocarcinomas (called gastric type adenocarcinomas) that are known to develop without HPV, may be caused by p53 mutations, and may be associated with Peutz–Jeghers syndrome . Other rare types of adenocarcinoma that may also fall into this category include clear cell and mesonephric carcinomas.…”

Section: Reasons Why Some Cervical Cancers Are Hpv‐negativementioning

confidence: 99%

Understanding the proportion of cervical cancers attributable to HPV

Brotherton

Budd

Saville

2020

Medical Journal of Australia

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PerspectivesUnderstanding the proportion of cervical cancers attributable to HPV Most cervical cancers can be prevented with HPV vaccination and screening S ince Walboomers and colleagues 1 published their findings in 1999, citing that 99.7% of cervical cancers are related to the human papillomavirus (HPV), this has become the standard understanding of the proportion of cervical cancers attributable to HPV.Two decades later, and with both HPV vaccination and HPV-based screening programs in place to prevent cervical cancer in Australia, it is prudent to review the available evidence to understand the potential for cervical cancer prevention through HPV-based public health interventions.

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Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes

Cited by 41 publications

References 73 publications

Gastric‐type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature

Gastric‐type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature

A rare case of gastric-type mucinous endocervical adenocarcinoma in a 59-year-old woman

Understanding the proportion of cervical cancers attributable to HPV

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