Cervical, Anal and Oral HPV in an Adolescent Inner-City Health Clinic Providing Free Vaccinations

Burk, Robert D.; Nucci-Sack, Anne; Shankar, Viswanathan; Peake, Ken; Lorde-Rollins, Elizabeth; Porter, Robert H.; Linares, L. Oriana; Rojas, Mary; Strickler, Howard D.; Díaz, Ángela

doi:10.1371/journal.pone.0037419

Cited by 36 publications

(50 citation statements)

References 21 publications

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“…11 The most common types detected (including cervical and anal) were HPV 51 and 58. In contrast, infections with HPV 16 were rare—found in less than 2% of anal samples—and concomitant infections widely varied depending on the HPV type detected.…”

Section: Anal Hpv Infection and Disease In Womenmentioning

confidence: 99%

Screening for Anal Cancer in Women

Moscicki

Darragh

Berry-Lawhorn

et al. 2015

Journal of Lower Genital Tract Disease

135

122

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Objective The incidence of anal cancer is higher in women than men in the general population and has been increasing for several decades. Similar to cervical cancer, most anal cancers are associated with human papillomavirus (HPV) and it is believed that anal cancers are preceded by anal high-grade squamous intraepithelial lesions (HSIL). Our goal was to summarize the literature on anal cancer, HSIL and HPV infection in women, and provide screening recommendations in women. Methods A group of experts convened by the ASCCP and the International Anal Neoplasia Society reviewed the literature on anal HPV infection, anal SIL and anal cancer in women. Results Anal HPV infection is common in women but is relatively transient in most. The risk of anal HSIL and cancer varies considerably by risk group, with HIV-infected women and those with a history of lower genital tract neoplasia (LGTN) at highest risk compared with the general population. Conclusions While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and have digital anorectal examinations to detect anal cancers. HIV-infected women and women with LGTN, may be considered for screening with anal cytology with triage to treatment if HSIL is diagnosed. Healthy women with no known risk factors or anal cancer symptoms do not need to be routinely screened for anal cancer or anal HSIL.

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Section: Anal Hpv Infection and Disease In Womenmentioning

confidence: 99%

Screening for Anal Cancer in Women

Moscicki

Darragh

Berry-Lawhorn

et al. 2015

Journal of Lower Genital Tract Disease

135

122

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“…The MSAHC provides free-ofcost comprehensive medical services for young people between 10 and 24 years of age and primarily of ethnic minority background and includes the teen parenting (TP) program. According to published center studies, the majority of patients (60.5 %) report living in households receiving Medicaid or not having medical insurance and 74 % are of low socioeconomic status (having themselves or their family ever used public assistance, food stamps, Medicaid, WIC, free school lunch, or suffered from food scarcity; Schlecht et al 2012).…”

Section: Methods Participantsmentioning

confidence: 99%

Parenting Stress, Child Characteristics, and Developmental Delay from Birth to Age Five in Teen Mother–Child Dyads

et al. 2015

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Given the risk for less optimal developmental attainment in children born to adolescent and young mothers, this study examined associations among child characteristics, parenting stress, and child risk for developmental delay from birth to age five years in mother-child dyads who attended a free-of-cost teen parenting program. Participants were 133 mothers and their target child classified in five age groups; mothers self-reported on the Parenting Stress Index-Short Form. While 68 % of children showed typical development across age groups, 32 % showed increased risk of developmental delay in five areas and overall using the Ages and Stages Questionnaire (ASQ-3). Maternal age did not increase the odds of child's developmental delay. Multivariate analyses showed that the adjusted odds ratio of delay was higher among boys (vs girls), in Personal-social (aOR = 6.2) and Overall (aOR = 2.7). Compared to baseline age group (1-9 months), the odds of delay were higher in age 10-18 months for Personal-social (aOR = 5.3); in age 19-31 months for Communication (aOR = 13.5) and Overall (aOR = 6.3); and in age 32-44 months for Communication (aOR = 7.0). The odds of a delay were higher in children of mothers with higher parenting stress in three of the five developmental areas (Fine Motor, Problem Solving, Personal-social) and Overall. Children's ages 3-4 and boys were associated with increased odds of delay in language and personal-social areas. Beyond screening for child developmental delay, surveillance for highly stressed mothers may be important to broaden risk reduction efforts among adolescent and young mother-child dyads served in primary care settings.

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“…Adolescent women presenting for health services and HPV vaccination were invited to participate in a prospective cohort study with repeated assessment every 6 months for cervical, anal, and oral HPV infection [19,20]. Women were aged 12-19 years at time of enrollment, were eligible to participate if they had already engaged in vaginal intercourse, and intended to receive or had already received the Food and Drug Administration-approved 4vHPV vaccine (GardasilMerck & Co., Kenilworth, New Jersey).…”

Section: Study Populationmentioning

confidence: 99%

“…This center provides free health services, including HPV vaccination, to adolescents and young adults aged 12-24 years [19,20]. We present here data on the prevalence and incidence of cervical and anal HPV infection after vaccination and assessed the impact of delayed uptake and completion of the 3-dose 4vHPV vaccine schedule on the risk of HPV infection and associated cervical cytological abnormalities.…”

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confidence: 99%

Risk of Delayed Human Papillomavirus Vaccination in Inner-City Adolescent Women

et al. 2016

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Background. Uptake of human papillomavirus (HPV) vaccine in the United States is slow, and the effectiveness of the vaccine has not been assessed in high-risk adolescent populations.Methods. We conducted a longitudinal study of 1139 sexually active, inner-city adolescent women receiving the 3-dose quadrivalent (4vHPV) vaccine. Cervical and anal specimens collected semiannually were tested using an L1-specific polymerase chain reaction assay. Postvaccination incidence of 4vHPV vaccine and nonvaccine HPV types, and risk of cervical cytological abnormalities, were assessed in relation to time to completion of all 3 vaccine doses.Results. Compared to vaccine naive women at enrollment, vaccinated women had significantly lower incidence rate ratios of cervical infection with HPV6/11/16/18 (0.2; 95% confidence interval [CI], .1-.4) and the related types HPV31 and HPV45 (0.4 [95% CI, .2-1.0] and 0.3 [95% CI, .1-.6], respectively), as well as significantly lower incidence rate ratios of anal infection with HPV6/11/16/18 (0.4; 95% CI, .2-.7). Notably, we observed higher risks of cervical HPV6/11/16/18 infection (hazards ratio [HR], 2.9; 95% CI, 1.0-8.0) and associated cytological abnormalities (HR, 4.5; 95% CI, .7-26.0) among women immunized at ≥15 years of age who took ≥12 months (vs <12 months) to complete the 3-dose regimen.Conclusions. Among adolescents immunized at ≥15 years of age, a longer time to complete the 3-dose schedule was associated with an increased risk of anogenital HPV6/11/16/18 infection and an increased incidence of associated cervical cytological abnormalities.

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Cervical, Anal and Oral HPV in an Adolescent Inner-City Health Clinic Providing Free Vaccinations

Cited by 36 publications

References 21 publications

Screening for Anal Cancer in Women

Screening for Anal Cancer in Women

Parenting Stress, Child Characteristics, and Developmental Delay from Birth to Age Five in Teen Mother–Child Dyads

Risk of Delayed Human Papillomavirus Vaccination in Inner-City Adolescent Women

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