Cervical and Vaginal Cytology

Cibas, Edmund S.

doi:10.1016/b978-1-4160-5329-3.00001-3

Cited by 13 publications

(9 citation statements)

References 171 publications

(151 reference statements)

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“…At times, their pale nuclear appearance and presence of fine cytoplasmic vacuoles can mimic glandular origin ( Figure 3C and D). 22 Some authors found similar results in their studies, indicating that intraepithelial squamous lesions, especially the high grade ones, are frequently diagnosed in the histopathologic examinations that follow cytologic tests giving atypical glandular indications. Renshaw et al 11 observe that 11.3% of the interpretations of AIS case revisions were high grade squamous intraepithelial lesions or squamous cell carcinomas.…”

Section: Discussionsupporting

confidence: 63%

Performance of the Cytologic Examination for the Diagnosis of Endocervical Adenocarcinoma in Situ

Zardo¹,

Thuler²,

Zeferino³

et al. 2009

Acta Cytologica

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Section: Discussionsupporting

confidence: 63%

Performance of the Cytologic Examination for the Diagnosis of Endocervical Adenocarcinoma in Situ

Zardo¹,

Thuler²,

Zeferino³

et al. 2009

Acta Cytologica

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“…Occasional cells can show binucleation or multinucleation. Cytoplasmic pigment and nuclear pseudoinclusions can also be identified, but are not always present . The absence of cytoplasmic pigment can make the identification of malignant melanoma even more challenging and may cause the lesion to be misdiagnosed .…”

Section: Discussionmentioning

confidence: 99%

“…The implementation of cervicovaginal Pap tests led to a rapid decline in cancer deaths attributed to cervical cancer throughout the 20th century . Although the cervicovaginal Pap test was originally designed to be used as a screening test for squamous intraepithelial lesions, meticulous screening of these cytology specimens can yield other diagnoses, such as glandular epithelial abnormalities, rare malignancies of the cervix and corpus uteri and metastatic lesions .…”

Section: Introductionmentioning

confidence: 99%

Metastatic melanoma of the uterine cervix diagnosed on cervical Pap smear: Case report and literature review

Shachner

Meter

2018

Diagnostic Cytopathology

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Metastatic cancer involving the uterine cervix is exceedingly rare, and accounts for less than 1% of cancer deaths. The cervix is an uncommon location for metastatic lesions due to its limited blood supply and fibrous stroma and metastatic melanoma of the cervix is particularly infrequent. To the best of our knowledge and literature review, there have only been nine reported cases in the literature of metastatic melanoma involving the uterine cervix that were diagnosed via cervicovaginal Pap smears, including the case being reported in this paper. Diagnosing metastatic melanoma on cervicovaginal cytology specimens is challenging, not only because of its rarity, but also because of the inherent ability of melanoma to take on many different cytomorphologic appearances. In such cases, the differential diagnosis may include a high‐grade squamous intraepithelial lesion, atypical glandular cells, adenocarcinoma and other poorly differentiated malignancies. We report a case of malignant melanoma to the cervix diagnosed by a routine cervical Pap smear in a young woman who was diagnosed with cutaneous melanoma 3 years prior. Because of the diagnosis rendered on her cervical Pap smear, she was subsequently found to have widespread metastatic disease. Although the cervical Pap smear is primarily intended to screen for squamous intraepithelial lesions, a high index of suspicion must be maintained for other less common entities, particularly when there is no evidence of a squamous intraepithelial lesion.

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“…Alleged advantages of LBC for gynecological cytology include improvement in specimen quality and adequacy, lower unsatisfactory rates, increased detection of precursor lesions, and the usage of residual samples for ancillary tests [8,9]. In general, studies that reported the use of LBC for body fluids and FNA specimens, including breast aspirates, found better cellular preservation, less cell overlapping and elimination of obscuring elements (blood, inflammatory cells and cellular debris) in comparison to CS [7,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

Gerhard

Schmitt²

2014

Acta Cytologica

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Objective: Fine-needle aspiration (FNA) is a safe and cost-effective technique for the diagnosis of breast lesions, especially when correlated with clinical and imaging studies. However, the success of breast FNA is highly dependent on the adequate preparation of cytological conventional smears (CS). The liquid-based cytology (LBC) technique consists of an automated method for preparing thin-layer cytological samples from cell suspensions collected in alcohol-based preservative. LBC is designed to improve CS by avoiding limiting factors such as obscuring material, air-drying and smearing artifacts. Study Design: We performed a review of the published literature about LBC applied to breast FNA. Results: LBC preparations of breast aspirates demonstrated better cellular preservation, less cell overlapping and elimination of blood and excessive inflammation compared to CS. Conversely, alterations in architecture and cell morphology as well as loss of myoepithelial cells and stromal elements have been described in LBC specimens, requiring training before applying this technique for diagnosis. Studies have shown a similar accuracy between LBC and CS for the diagnosis of breast lesions. LBC also permits the use of residual material for ancillary tests, which is an important advantage compared to CS. Conclusions: LBC can be safely applied to breast FNA, showing a similar diagnostic accuracy to CS.

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Cervical and Vaginal Cytology

Cited by 13 publications

References 171 publications

Performance of the Cytologic Examination for the Diagnosis of Endocervical Adenocarcinoma in Situ

Performance of the Cytologic Examination for the Diagnosis of Endocervical Adenocarcinoma in Situ

Metastatic melanoma of the uterine cervix diagnosed on cervical Pap smear: Case report and literature review

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

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