Introduction: Cervical cancer is the most diagnosed cancer and the leading cause of cancer death in 36 low and middle-income countries with the majority being located in sub-Saharan Africa (SSA), South America, and South Eastern Asia. The highest regional incidence and mortality occur in SSA. Despite the high efficacy and cost-effectiveness of the HPV vaccine in preventing cervical cancer, its uptake remains unacceptably low in SSA. This scoping review aims to integrate evidence from SSA on social determinants of HPV vaccine uptake with complementary evidence on interventions to promote its uptake. Methods and analysis: The proposed review will be conducted following the guidelines by the Joanna Briggs Institute Scoping Review Methodology Group. Additionally, sequential explanatory design will guide the integration of determinants evidence with interventions evidence. This scoping review will be reported per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) checklist. Five databases, PubMed/MEDLINE, LIVIVO, Google Scholar, BASE (Grey Literature), Preprints databases (e.g. OSF and MedRxiv), and African Journals Online (AJOL) will be searched, with results limited to English language publications and those published from 2006 to 2024. Two forms will be used for data extraction from the determinants and interventions studies by two independent reviewers. A narrative summary of evidence from the both determinants and interventions studies will be conducted. Furthermore, a multi-level analysis will be conducted to explore the intersections of determinants across socioecological levels of health behaviour. A further integrative cross-study analysis of results from determinants and interventions studies will be conducted where the determinants evidence will be used to interrogate the intervention evidence. Data will be presented in tables and matrices. Ethics and dissemination: No ethical approval will be required for this study because it will be based on data collected from publicly available records. The review results will be disseminated widely through a peer-reviewed publication and other forums such as workshops, conferences, and meetings with local health administrators, policymakers and other wider stakeholder engagements. This protocol has been registered with Open Science Framework (https://doi.org/10.17605/OSF.IO/5JKZ8)
