Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16 573 women with cervical cancer and 35 509 women without cervical cancer from 24 epidemiological studies

Appleby, Paul N.; Beral, Valerie; González, Amy Berrington de; Colin, Didier; Franceschi, Silvia; Goodhill, A; Green, J; Peto, Julian; Plummer, Martyn; Sweetland, S

doi:10.1016/s0140-6736(07)61684-5

Cited by 419 publications

(120 citation statements)

References 57 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…In contrast to the recent meta-analysis [17], the present study failed to establish any increased risk of cervical disease for the length of HOC usage. Unexpectedly, women testing HR-HPV-positive and those having cervical abnormalities ranging from CIN1 to invasive cancer presented with shorter times of HOC usage, which can be considered a contentious finding.…”

Section: Discussioncontrasting

confidence: 99%

“…In the present cohort of over 12,000 women, we failed to confirm any part of the results from this pivotal meta-analysis [17]. Our data unequivocally showed that hormonal contraceptive use (or length of use) is not an independent risk factor of high-grade CIN lesions.…”

Section: Discussioncontrasting

confidence: 66%

“…Re-analysis of the data from the International Collaboration of Epidemiological Studies of Cervical Cancer have recently confirmed that current and recent use of combined oral contraceptives is indeed associated with an increased risk of invasive CC [17]. According to these sizeable figures from 24 epidemiological studies, the relative risk in current users augments with increasing duration of oral contraceptive use.…”

Section: Discussionmentioning

confidence: 99%

“…Use for 5 or more years (mean: 11.1 years) is associated with doubling of the risk. Relative risks were broadly similar among women likely not to have been screened and in women likely to have been screened, in analyses restricted to HR-HPV+ women, as well as for CIN3/carcinoma in situ [17]. …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Hormonal Contraceptives and the Length of Their Use Are Not Independent Risk Factors for High-Risk HPV Infections or High-Grade CIN

Longatto‐Filho

Hammes

Sarian

et al. 2010

Gynecol Obstet Invest

View full text Add to dashboard Cite

Aims: To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study. Methods: A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC – oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+. Results: HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions. Conclusions: No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal Contraceptives and the Length of Their Use Are Not Independent Risk Factors for High-Risk HPV Infections or High-Grade CIN

Longatto‐Filho

Hammes

Sarian

et al. 2010

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Cervical cancer risk is double in current oral contraceptives (OC) users who have used OCs for 5 or more years, compared to people who have never used it [21]. Cervical cancer risk may increase with longer duration of use, but is no higher in women who last took OCs 10 or more years than in those who have never used it [22].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and Histological Profile of Cervical Cancer in Cameroon: About 2078 Cases

Paul¹,

Charlotte²,

Jules³

et al. 2016

OJOG

View full text Add to dashboard Cite

Association of Hormonal Contraceptive Use With Adverse Health Outcomes

et al. 2022

View full text Add to dashboard Cite

Key Points Question What are the quality and certainty of evidence for an association between hormonal contraceptive use and the risk of adverse health outcomes in meta-analyses of randomized clinical trials and cohort studies? Findings In this umbrella review of 58 meta-analyses of randomized clinical trials and cohort studies describing 156 associations between hormonal contraceptive use and adverse health outcomes among women, no associations with adverse outcomes, including cardiovascular and cancer risk, were supported by high-quality evidence. However, the association between the use of a levonorgestrel-releasing intrauterine system and reductions in endometrial polyps associated with tamoxifen use was graded as having high-quality evidence. Meaning The results of this umbrella review supported preexisting understandings of the risks and benefits associated with hormonal contraceptive use, suggesting that the associations between hormonal contraceptive use and adverse health outcomes are not supported by high-quality evidence.

show abstract

Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16 573 women with cervical cancer and 35 509 women without cervical cancer from 24 epidemiological studies

Cited by 419 publications

References 57 publications

Hormonal Contraceptives and the Length of Their Use Are Not Independent Risk Factors for High-Risk HPV Infections or High-Grade CIN

Hormonal Contraceptives and the Length of Their Use Are Not Independent Risk Factors for High-Risk HPV Infections or High-Grade CIN

Epidemiological and Histological Profile of Cervical Cancer in Cameroon: About 2078 Cases

Association of Hormonal Contraceptive Use With Adverse Health Outcomes

Contact Info

Product

Resources

About