Cervical cancer in pregnancy at various gestational ages

Rodrigo, Sol Gómez; Calderon, J. Garrido; Dionisi, Jorge Nicolas; Santi, Agostina; Mariconde, José María; Rosato, Otilio; Amant, Frédéric

doi:10.1136/ijgc-2020-002189

Cited by 5 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For patients with stage IA1 cervical cancer who are less than 20 weeks pregnant, expectant treatment with regular cytology or colposcopy every 12 weeks is recommended, as the effect of pregnancy on tumor biology is still uncertain [ 11 ]. From 22 weeks of gestation onwards, several options are available, such as regular monitoring until delivery, delayed treatment after childbirth, or administering 2 to 3 courses of neo-adjuvant chemotherapy to control tumor progression until the fetus is mature.…”

Section: Discussionmentioning

confidence: 99%

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review

Chen

Huang

Sun

et al. 2023

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background The incidence of cervical neuroendocrine carcinoma (CNECC) during pregnancy is extremely rare. Insufficient awareness of gynecological tumor screening, as well as atypical and insidious initial clinical symptoms, may result in diagnostic delays and misdiagnosis. There is no standardized treatment for cervical cancer in pregnancy. Herein, we present a case of cervical neuroendocrine carcinoma diagnosed in the third trimester of pregnancy. Case presentation A 26-year-old female at 30 1/7 weeks of gestation presented with lower back and sacroiliac joint pain, abdominal distension, and lower limb dyskinesia. A pelvic examination revealed a large fungating gray mass that encompassed the entire cervix, with cervical contact bleeding testing positive. Imaging studies showed a significant cervical mass, diffuse liver changes, and metastasis to multiple sites. Biopsy results revealed poorly differentiated cervical carcinoma exhibiting high-grade neuroendocrine features, consistent with a diagnosis of large cell neuroendocrine carcinoma. The patient was diagnosed with stage IVB CNECC with HPV18 (+), and due to the gestational age of the fetus and her deteriorating condition, she underwent cesarean section delivery after receiving fetal lung maturation therapy. Following surgery, eight cycles of neoadjuvant chemotherapy were applied. Unfortunately, she succumbed to multiple tumor metastases six months post-treatment. Despite this tragic outcome, the infant was discharged in a healthy condition. Conclusions CNECC during pregnancy, particularly the large-cell type, is an ultra-rare condition with poor prognosis. This case highlights the importance of individualized treatment approach and the need for better screening, early detection, and treatment. Given the rarity of the disease, further research is warranted to determine the prognostic factors and develop effective treatment strategies for this ultra-rare and aggressive malignancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review

Chen

Huang

Sun

et al. 2023

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Pregnancy itself may not have a negative impact on the prognosis of cervical cancer, but if the pregnancy continues and treatment is delayed, it will affect the maternal prognosis to a certain extent ( 5 , 12 , 13 ). In the first trimester of pregnancy, it takes a long time for the fetus to mature, which has a high risk of disease progression.…”

Section: Multidisciplinary Diagnosis and Treatment In Ccipmentioning

confidence: 99%

“…The initial treatment time of delayed treatment should not exceed 32 ~ 34 weeks of pregnancy, and pregnancy can be terminated after fetal lung maturation ( 14 ). CCIP patients suggest a cesarean section to terminate the pregnancy, and cervical cancer should be treated routinely after delivery ( 13 ). The prognosis of CCIP patients is similar to that of non-pregnancy, related to FIGO staging and treatment methods ( 17 ).…”

Section: Multidisciplinary Diagnosis and Treatment In Ccipmentioning

confidence: 99%

Chinese Expert Consensus on ovarian function and fertility preservation of cervical cancer in pregnancy (2023)

Ruan

2023

Front. Endocrinol.

View full text Add to dashboard Cite

Cervical cancer in pregnancy (CCIP) refers to cervical cancer diagnosed during pregnancy, the most common gynecological malignant tumor. Because of the special physiological changes of CCIP, although preserving ovarian function and fertility is very important, the methods are very limited. There is no guideline or consensus on the preservation methods of ovarian function and fertility in this special period. Therefore, the Committee of Fertility Protection and Preservation of China Association for the Promotion of Health Science and Technology, combined with the Chinese Society of Gynecological Endocrinology affiliated to the International Society of Gynecological Endocrinology, Society Endocrinology Branch of Beijing Institute of Obstetrics & Gynecology, combined with Society on Fertility Preservation affiliated with the Chinese Preventive Medicine Association, organized relevant experts from different disciplines to formulate this consensus, in order to guide ovarian function and fertility preservation of CCIP patients.

show abstract

“…Treatment of CC for pregnant women depends on the stage of disease, histopathological subtype and also a week of gestation and the patient's desire to preserve the pregnancy and reproductive ability [21]. In the most common histopathological subtypes (squamous cell carcinoma, adenocarcinoma, and glandular-squamous carcinoma) the prognosis is comparable, so the treatment approach can be similar.…”

Section: Treatmentmentioning

confidence: 99%

“…Locally advanced CC needs to be treated immediately, except for a short delay in the third trimester for fetal lungs to mature [22,23]. Common treatment of locally advanced CC is chemoradiotherapy, but during pregnancy, radiotherapy of the pelvic region is not recommended as it may cause adverse reactions such as spontaneous abortion or congenital malformations [22,24].…”

Section: Locally Advanced CCmentioning

confidence: 99%

Cancers in pregnancy: a multidisciplinary dilemma

Aurast,

Dzieciątkowska,

Grzejda

et al. 2023

Arch Med Sci Civil Dis

View full text Add to dashboard Cite

Malignancies during pregnancy present a multifaceted challenge, with an incidence of approximately 81–140 cases per 100,000 pregnancies, constituting a statistically rare phenomenon. The number of incidences is constantly growing due to the delay of women’s reproductive decisions. Predominant malignancies include breast cancer, cervical cancer, melanoma, and hematological cancers like Hodgkin’s disease. Physiological gestational changes can lead to delayed diagnosis by masking the cancer’s symptoms. Accurate diagnosis and staging, coupled with considerations of gestational age and assessment of fetal and placental structural development, are pivotal in shaping therapeutic decisions. Chemotherapy, surgery and in some cases radiotherapy are considered possible options depending on gestational age, both maternal and fetal conditions, and the type of cancer. This review provides a concise overview of common cancers in pregnancy, emphasizing their diagnosis and optimal treatment options. The comprehensive approach takes into account both maternal and fetal well-being, recognizing the intricate balance necessary for effective management within the unique context of pregnancy.

show abstract

Cervical cancer in pregnancy at various gestational ages

Cited by 5 publications

References 15 publications

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review

Chinese Expert Consensus on ovarian function and fertility preservation of cervical cancer in pregnancy (2023)

Cancers in pregnancy: a multidisciplinary dilemma

Contact Info

Product

Resources

About