Cervical cancer in the era of precision medicine: A perspective from developing countries

Poondla, Naresh; Madduru, Dhatri; Duppala, Santosh Kumari; Suresh, Velpula; Nunia, Vandana; Kharb, Simmi; Ghatak, S.; Mishra, Ashwani Kumar; Vuree, Sugunakar; Neyaz, Kausar; Suravajhala, Prashanth

doi:10.1016/j.adcanc.2021.100015

Cited by 4 publications

(3 citation statements)

References 85 publications

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“…Early intervention through vaccination and screening is crucial in combating CC. Unlike Western developed countries, where cancer rates have declined due to advancements in screening, treatment, and lifestyle changes like smoking cessation, low-income and developing nations are witnessing a rise in cancer incidence and mortality 8 . Oncogenic viruses, including HPV, play multiple roles in carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Unravelling The Complexities of Cervical Cancer: A Comprehensive Exploration

Bhargava,

Abraham,

Srinivas

et al. 2024

Int J Tre Onc Sci

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Cervical cancer (CC) ranks as the second most common cause of cancer-related deaths among women aged 20-39, resulting in ten premature deaths weekly. CC affects women worldwide as the most common form of genital cancer, with approximately 500,000 new cases diagnosed annually. Besides the risk of death, CC can lead to increased morbidity, causing symptoms like pain, haemorrhage, and kidney failure. These complications pose significant challenges to treatment, particularly in areas with limited healthcare access. Immune dysregulation and chronic inflammation further contribute to CC pathogenesis, creating a pro-carcinogenic microenvironment through immune cell recruitment, cytokine release, and inflammatory responses triggered by persistent HPV infection. Moreover, understanding the socio-economic determinants influencing the prevalence of CC and promoting awareness can contribute to effective public health interventions. Research endeavours in these domains are vital to reduce the burden of CC, enhance early detection, and ultimately save lives. This review covers recent research on CC global epidemiology, intricate pathogenesis insights, protein-based HPV vaccines, and diverse treatment modalities, including recurrent cases. Molecular markers indicating prognosis and the role of artificial intelligence. The review will briefly highlight preventive strategies, offering a comprehensive overview of crucial research areas in CC.

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Section: Introductionmentioning

confidence: 99%

Unravelling The Complexities of Cervical Cancer: A Comprehensive Exploration

Bhargava,

Abraham,

Srinivas

et al. 2024

Int J Tre Onc Sci

View full text Add to dashboard Cite

show abstract

“…A review of 127 literature across issues on incidence, causes, treatment modalities, prevention and other issues related to cervical cancer in developing countries [24]. The reviewers concluded that if cervical cancer detection awareness and cervical cancer treatment were raised, cervical cancer will be eliminated and the reproductive health of the women will improve.…”

Section: Introductionmentioning

confidence: 99%

Impact of Women’s Knowledge, Perception and Attitude towards Cervical Cancer Screening in South West Nigeria

Owolabi¹,

Jegede

Kolade

et al. 2022

Preprint

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Objectives: Although cancer of the cervix is a preventable disease and services associated to cervical cancer screening has proven to drastically reduce morbidity and mortality. This study aimed to investigate the impact of women’s knowledge, perception and attitude towards Cervical Cancer Screening in South West Nigeria. There is low uptake of Cervical cancer screening (CCS) in developing countries. In the same vein, preventive services are unorganised, sporadic and often expensive. Method: This study draws from a cross-sectional survey of 117 respondents from purposively selected rural and urban locations in southwest Nigeria to investigate the impact of awareness, attitudes, risk perception and socio-economic variables on CCS uptake.Results: The results of the descriptive statistics, Chi-square tests and regression analyses show that awareness and education level are significantly associated with CCS uptake. The respondent’s level of knowledge of signs and symptoms of cervical cancer is low. Conclusion: The findings underline the importance of awareness and enlightenment campaign as a key factor to drive CCS uptake. Furthermore, health care practitioners need to be actively engaged in the design and implementation of interventions. Finally, governments need to invest resources and funding to make CCS accessible and affordable in order to reduce both morbidity and mortality.

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“…GLOBOCAN 2020 studies suggest that India and China contribute more than a third of CC cases. In India the incidence rates are 96,922 (17%) and death rates are 60,078(19.3%) per year [2,3]. While CC is a major health problem in young women and middleaged in developing and underdeveloped countries, over the past few years, there is a decline in age standardised mortality in developed countries like the US, Europe, and the UK due to the increased awareness in screening CC diagnosis, and HPV vaccination [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

Exome Sequencing reveals characteristic KMT2C mutations in the Indian Phenotype of Cervical Cancer

Duppala¹,

Kour²,

Shukla³

et al. 2022

Preprint

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We attempted to understand the cervical cancer patient samples through Whole Exome Sequencing. We derived the variants from raw reads via our in-house benchmarked pipeline and validated the variants by IGV. This is the first cervical cancer exome data from the Indian cohort. Background: Cervical cancer (CC) is caused mainly by persistent infections of high-risk HPV, reduced parity, and factors like a decrease in average socioeconomic levels. We keep this because no cervical cancer exome data is available from the Indian cohort. Methods: The CC patient clinical samples were initially subjected to preparation using Qiagen DNA extraction, quantified, and the library preparation using the Agilent target enrichment system. Further, exome capture by Illumina platform (100X), quality check, alignment, and variant calling followed by the downstream analysis and finally visualized by IGV. Results: We observed a large number of SNVs or mutations from an Indian perspective, such as KMT2C, OR4M1, PDPR2P, EPHB1, FAS, OPCML, MGST1, C1QTNF9, HS6ST3, OR4K2, PRPSAP2, KCNJ12, FIGNL1, SFXN1, BAGE2, ARVCF, NAMPT variants of significance, unknown significance and possibly significant are reported. Conclusion: For the first time, KMT2C is observed as a novel potent mutation and pathogenic, showing the variant position at (7:152265091, T>A, SNV 62478356) from the Indian context in CC. Further, we visualized and validated the mutations using the Integrative Genomic Viewer (IGV) browser. Finally, we discuss the inherent challenges through KMT2C mutations.

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Cervical cancer in the era of precision medicine: A perspective from developing countries

Cited by 4 publications

References 85 publications

Unravelling The Complexities of Cervical Cancer: A Comprehensive Exploration

Unravelling The Complexities of Cervical Cancer: A Comprehensive Exploration

Impact of Women’s Knowledge, Perception and Attitude towards Cervical Cancer Screening in South West Nigeria

Exome Sequencing reveals characteristic KMT2C mutations in the Indian Phenotype of Cervical Cancer

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