Cervical Cancer in Younger Women

Andrews, F D O Stephen; Linehan, J.J.; Melcher, D. H.

doi:10.1016/s0140-6736(78)92659-4

Cited by 26 publications

(2 citation statements)

References 5 publications

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“…Much of the reported increase in the frequency of epithelial dysplasias and neoplasias in teenagers (2,8,30) must be attributed to a venereally transmitted agent. T h e age distribution curve of condyloma acuminatum (23) closely mathces the age distribution curve of all condyloma types in our material, thus supporting the concept that these morphologically distinct lesions have a common etiologic agent, the venereally transmitted papovavirus (1,6,19,23,24,28,31).…”

Section: Discussionmentioning

confidence: 99%

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Syrjänen¹

1980

Obstetrical & Gynecological Survey

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Syrjànen KJ (Dept of Pathology, Pdijat-Hame Central Hospital, Lahti, Finland). Condylomatous epithelial changes in the uterine cervix and their relationship to cervical carcinogenesis. Int J Gynaecol Obstet 17: 415-420, 1980 Two hundred twenty-six (226) women with histologically verified dysplastic or neoplastic epithelial lesions in the uterine cervix were assessed for the presence (CO-series) or absence (N-CO-series) of the three newly established types of condylomatous lesions. Both the CO-series and the N-COseries comprised 113 patients. Histologic changes fulfilling the previously outlined criteria of the (a) fiat, (b) inverted and (c) papillomatous condylomas were found in association with all degrees of epithelial atypia, from mild dysplasia to frankly invasive carcinoma. The flat type was most common, comprising 69% of all condylomas. The inverted and papillomatous types were relatively rare, with frequencies of 18.6% and 12.4%, respectively. The mean age of the patients in the CO-series was 30.9 years, that of the N-CO-series patients was 39.3 years (p < 0.0001). The causal relationship between the cervical condylomas and cervical carcinoma is discussed. The conclusion is drawn that this possibility needs to be seriously considered when searching for a venereally transmitted agent as an etiologic factor of cervical carcinoma. Int J Gynaecol Obstet 17

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Section: Discussionmentioning

confidence: 99%

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Syrjänen¹

1980

Obstetrical & Gynecological Survey

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“…It has been postulated that the biologic imma turity of the cervix associated with normal adolescent developm ent may leave the adolescent cervix vulnerable to STD infection including HP V (29,30). In a previous study, we noted that biologic imm aturity measured by Onc e/w k age of menarche was associated with CIN in adolescents (3 1).…”

Section: 28 Dfmentioning

confidence: 95%

Human Papillomavirus Infection Sexually Active Adolescent Females: Prevalence and Risk Factors

et al. 1990

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ABSTRACT. We examined the prevalence of human papiIIomavirus (HPV) infection, and associated risk factors for infection with HPV types 6, 11, 16, 18,31,33, and 35, in 661 sexually active adolescent females attending family planning clinics. Fifteen percent were positive for HPV DNA by RNA-DNA dot-blot hybridization. More than 60% of the HPV-positive subjects harbored at least one of the following cancer-related HPV types: 16, 18,31, 33, or 35. Those with HPV had a mean range of four to 10 lifetime sexual partners compared with a mean range of one to three in those without HPV (p < 0.001). After the analysis was adjusted for number of lifetime sexual partners, no other risk factor was associated with HPV infection. We conclude that oncogenic-related HPV types are common sexually transmitted organisms found in our population. The strong relationship with number of sexual partners suggests that acquisition of HPV infection is predominantly influenced by sexual behavior. However, in our population, confounders such as oral contraceptive use, past history of Chlamydia trachomatis infection, or substance abuse were not found to be significant independent risk factors. (Pediatr Res 28: 507-513, 1990) have been performed in populations with both HPV infection and neoplasia (i.e. dysplasia clinic populations), it has been difficult to differentiate cofactors associated with neoplasia from those associated with HPV infection. Distinguishing between the risk factors for HPV infection and those associated with progression to CIN or cancer is critical in understanding the pathogenesis of the disease because the risk factors may not be the same. Studies that examine populations with relatively early HPV infection, defined by a short exposure time, may be best suited for distinguishing these risk factors. Adolescents may serve as such a population because the rate of abnormal cytology in teens is lower than that found in older adult women, and adolescents have not been sexually active as long as most adult women. Therefore, the average time course from infection and acquisition of the virus to the gynecology clinic visit is expected to be less for the adolescent than for the older woman.The purposes of our study were to determine the prevalence of HPV types 6, II, 16, 18, 31, 33, and 35 among a sexually active adolescent female population and to identify factors associated with acquisition of these specific HPV types. SUBJECTS AND METHODSAll sexually active females aged 13 to 19 y attending family planning clinics and having a pelvic examination for any reason on the day of the study were asked to participate. Sites consisted of an urban university-based adolescent gynecology clinic and two community-based family planning clinics, one urban and one surburban. Reasons for visits included family planning, STD complaints, pregnancy-related problems, and other gynecologic problems. Persons attending the family planning clinics were predominantly lower to middle class citizens. Most of those who attended these clinics were white...

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Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Syrjänen

1980

Intl J Gynecology & Obste

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Two hundred twenty-six (226) women with histologically verified dysplastic or neoplastic epithelial lesions in the uterine cervix were assessed for the presence (CO-series) or absence (N-CO-series) of the three newly established types of condylomatous lesions. Both the CO-series and the N-CO-series comprised 113 patients. Histologic changes fulfilling the previously outlined criteria of the (a) flat, (b) inverted and (c) papillomatous condylomas were found in association with all degrees of epithelial atypia, from mild dysplasia to frankly invasive carcinoma. The flat type was most common, comprising 69% of all condylomas. The inverted and papillomatous types were relatively rare, with frequencies of 18.6% and 12.4%, respectively. The mean age of the patients in the CO-series was 30.9 years, that of the N-CO-series patients was 39.3 years (p less than 0.0001). The causal relationship between the cervical condylomas and cervical carcinoma is discussed. The conclusion is drawn that this possibility needs to be seriously considered when searching for a venereally transmitted agent as an etiologic factor of cervical carcinoma.

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Cervical Cancer in Younger Women

Cited by 26 publications

References 5 publications

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

Human Papillomavirus Infection Sexually Active Adolescent Females: Prevalence and Risk Factors

Condylomatous Epithelial Changes in the Uterine Cervix and Their Relationship to Cervical Carcinogenesis

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