Cervical cancer in Zimbabwe: a situation analysis

Kuguyo, Oppah; Matimba, Alice; Tsikai, Nomsa; Magwali, Thulani; Madziyire, Mugove Gerald; Gidiri, Muchabayiwa Francis; Dandara, Collet; Nhachi, Charles

doi:10.11604/pamj.2017.27.215.12994

Cited by 57 publications

(103 citation statements)

References 44 publications

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“…The online medical service platform and knowledge base are developing rapidly. A professional platform should be added to disseminate relevant knowledge on a regular basis, so that people can quickly and comprehensively increase their knowledge of HPV and HPV vaccines [5,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…To improve knowledge of the disease among the women of this region and increase the HPV vaccination rate, on the one hand, requires appropriate education and follow-up from medical staff, and publicity via the media or internet. On the other hand, the support of vaccine suppliers is important, for example, in developing low-price vaccines and launching corresponding policy incentives [2,21]. In addition, factors such as family income, education level, culture, and conservative attitudes influence women's awareness of CC in northeastern China.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China

Ning

Liu

et al. 2019

J Canc Educ

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This study aimed to research the understanding and knowledge of cervical cancer, human papilloma virus (HPV), and HPV vaccination, and the acceptance of HPV vaccination, among a population of women in northeastern China. A cross-sectional survey was carried out by questionnaire to investigate knowledge of cervical cancer, HPV, and HPV vaccination. The 230 female participants were native residents of northeastern China, and their ages ranged between 18 and 65 years. Questionnaires were randomly acquired by the respondents from online and paper questionnaire distribution. The questionnaire included questions on three major aspects to record people's perceptions of cervical cancer, HPV, and vaccines. Of the sample of 230 women surveyed, 80.9% had heard of cervical cancer, but understanding was only 15.7%; 38.3% knew about HPV; 20% knew about HPV vaccine; 39.6% agreed to receive HPV vaccination, and the remainder were mainly concerned about its safety and effectiveness. Data analysis showed that age, family income, and whether there was experience of screening all influenced knowledge of cervical cancer, but this was not statistically significant. The level of education had no obvious effect on the degree of knowledge about cervical cancer; however, with an improvement in education, women's awareness of HPV vaccine improved significantly (p < 0.05). Women who have received cervical cancer screening had significantly greater knowledge about cervical cancer and HPV than those with no screening (p < 0.05). Women in northeastern China have little knowledge of cervical cancer, HPV, and HPV vaccine, lack disease knowledge, and hold a skeptical attitude about HPV vaccination. Medical institutions are the main channel providing information to these women. Keywords Cervical cancer. Screening. HPV. Vaccinations. Knowledge and acceptability Cervical cancer (CC) is the third highest cause of cancerrelated death for females in low-and middle-income countries Yu-e Ning and Yao Liu contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China

Ning

Liu

et al. 2019

J Canc Educ

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“…Similarly, work from Malawi found HPV35 to be the third most frequently detected hrHPV type in cervical cancers 10 . Furthermore, HPV35 is the most common hrHPV among women in rural Zimbabwe (19/648, 2.9%) 11 , and is the fifth most frequently identified hrHPV type in cervical cancers in Zimbabwe 12,13 . While specific genetic variants have been associated with carcinogenesis in other hrHPV types, HPV35 sequence data is relatively limited 1,2,[14][15][16] .…”

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confidence: 99%

Whole-Genome Analysis of Cervical Human Papillomavirus Type 35 from rural Zimbabwean Women

Fitzpatrick

Hahn

Mandishora

et al. 2020

Sci Rep

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Human papillomavirus (HPV) types differ by geographic location and the ethnicity of the human host, which may have implications for carcinogenicity. HPV35 is one of the least frequently identified highrisk types in north America and europe but was the most common high-risk HpV (hrHpV) infection in a cohort in rural Zimbabwe. Whole genome analysis is limited for HPV35; no such studies have been performed in Zimbabwe. Of 648 women in the initial cohort in Zimbabwe, 19 (19/648, 2.9%) tested positive for HPV35, and eight samples were successfully sequenced for HPV35. The maximum number of sequence variants for the whole genome was 58 nucleotides (0.7%) compared to the prototype (58/7879). The maximum number of sequence variants in E6 and E7 was 3 (3/450, 0.7%) 2 (2/300, 0.7%), respectively. These are the first HPV35 whole genome sequences from Zimbabwe, and these data further lend support to the carcinogenicity of HPV35 despite limited sequence heterogeneity. Further studies to determine carcinogenic effects and impact of HPV vaccinations are warranted, especially in sub-Saharan Africa.

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“…Despite the increasing availability of prevention and screening programmes, morbidity and mortality rates remain very high due to limited, centralized treatment services (Nyakabau, 2014;Kuguyo et al, 2017). While access and utilization of treatment and care for cervical cancer remains a huge challenge predominantly due to limited resources (Kuguyo et al, 2017), standardized tools to measure them remain limited in Africa. Understanding service access and utilization patterns is the first step towards evidence-based programme improvement and formulation of relevant national policies.…”

Section: Introductionmentioning

confidence: 99%

“…The ZDHS wealth quintile asset variables were simplified by adopting the approach from previous work by Chakraborty et al (2016) to shorten the questionnaire for ease of administration. Variables to measure access and utilization of cervical cancer treatment and care were adopted from ZDHS and literature (Bruni et al, 2016;Nyakabau, 2014;Kuguyo et al, 2017;Sundaresan et al, 2016;Margolis et al, 1995;ZDHS, 2015;Andersen & Newman, 2005).…”

Section: Introductionmentioning

confidence: 99%

Design and Validation of Questionnaires Investigating Access and Utilization of Cervical Cancer Treatment and Palliative Care

Tapera¹,

Dreyer²,

Stray‐Pedersen³

et al. 2018

GJHS

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BACKGROUND: Standardized tools to evaluate access and utilization of cervical cancer treatment and care remain scarce in developing countries. The objective of this study was to validate questionnaires to investigate access and uptake of cervical cancer treatment and palliative care. MATERIALS & METHODS: We designed and validated two questionnaires for patient and community and health worker surveys to determine the main constructs of each of the draft questionnaires. Pilot data was collected randomly amongst 50 patient and community participants and 14 health workers respectively in Chitungwiza, Zimbabwe. Content and face validity were assessed qualitatively from expert evaluations. Construct validity, reliability and internal consistency testing were conducted using exploratory factor analysis and Cronbach’s alpha correlation coefficient respectively. RESULTS: Twelve (12) experienced researchers, based on convenience, reviewed the questionnaires and validated their draft constructs based on experience and literature. Each of the questionnaires was sub-divided into 4 separate mini-questionnaires respectively. All the eight mini-questionnaires were analyzed independently and Kaiser-Meyer-Olkin coefficients ranged from 0.5-0.9 and Bartlett’s sphericity tests were all significant, p<0.001, showing promising good constructs. Patient and community questionnaire had 15 meaningful constructs while the health worker questionnaire had 13. Cronbach’s alpha (α) coefficients for internal consistency reliability testing of all the final constructs were greater than the minimum acceptable threshold of 0.70. CONCLUSION: This analysis revealed the validity and reliability of questionnaires that could be used to evaluate access and utilization of cervical cancer treatment and palliative care in countries affected by the disease.

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Cervical cancer in Zimbabwe: a situation analysis

Cited by 57 publications

References 44 publications

Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China

Knowledge of Cervical Cancer, Human Papilloma Virus (HPV) and HPV Vaccination Among Women in Northeast China

Whole-Genome Analysis of Cervical Human Papillomavirus Type 35 from rural Zimbabwean Women

Design and Validation of Questionnaires Investigating Access and Utilization of Cervical Cancer Treatment and Palliative Care

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