Cervical Cancer Incidence in Ontario Women: Differing Sociodemographic Gradients by Morphologic Type (Adenocarcinoma Versus Squamous Cell)

Prummel, Maegan V.; Young, Stephanie; Candido, Elisa; Nishri, Diane; Elit, Laurie; Marrett, Loraine D.

doi:10.1097/igc.0000000000000217

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Meanwhile, in Uganda, less education was associated with a higher risk of contracting high-risk human papillomavirus (HR-HPV) ( 66 ). In Canada, there were more CC cases in rural and poorer areas than in urban or affluent locations ( 67 ). A meta-analysis suggested that low SES (OR: 2.68) or a low level of education (OR: 1.97) increases the risk of developing CC ( 68 ).…”

Section: Resultsmentioning

confidence: 99%

Risk factors for the development of cervical cancer: analysis of the evidence

Luvián-Morales,

Gutiérrez-Enríquez,

Granados-García

et al. 2024

Front. Oncol.

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IntroductionCervical cancer (CC) is the fourth most prevalent female cancer globally. Understanding its epidemiology is crucial for devising practical strategies suited to geographic and social contexts to attain the global eradication of CC. Hence, this study examined the latest evidence of risk factors contributing to CC development.MethodsAn independent literature search was conducted on PubMed using MESH terms. The primary sources were meta-analyses published from 2010 to 2023, which detail updated evidence on risk factors associated with CC. Additionally, the quality of the evidence was evaluated using the GRADE system and recommendations were made accordingly.ResultsThe main risk factors related to the cause of CC include co-infections with other sexually transmitted infections, genetic markers, cervicovaginal microbiota, nutritional factors, comorbidities that affect the immune response, smoking, and the use of hormonal contraceptives with a quality evidence based on the GRADE scale moderate.ConclusionsSince the necessary cause for CC is persistent cervicovaginal HPV, all the risk factors implicated in the causality of CC act as non-independent cofactors that increase the risk of CC. Thus, changes in public policies aimed at addressing these risk factors are highly recommended and can substantially decrease the risk of CC.

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Section: Resultsmentioning

confidence: 99%

Risk factors for the development of cervical cancer: analysis of the evidence

Luvián-Morales,

Gutiérrez-Enríquez,

Granados-García

et al. 2024

Front. Oncol.

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“…За даними різних авторів [2,3,4,10], аденокарцинома шийки матки (АКШМ) становить 8-26 % випадків усіх РШМ, але має більш несприятливий прогноз ніж плоскоклітинний РШМ. Крім того, АКШМ рідше виявляють на ранніх стадіях, оскільки пухлина локалізується в цервікальному каналі і не візуалізується при гінекологічному огляді [3,4,5,8,10].…”

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“…Проте, незважаючи на актуальність проблеми АКШМ, у вітчизняній та зарубіжній літературі цій нозології, на відміну від плоскоклітинного РШМ, приділяється незаслужено мало уваги [4,8,10]. Ці роботи поодинокі та присвячені, в основному, методам лікування занедбаних її форм.…”

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Clinical features of adenocarcinoma of the cervix

Zelinska¹,

Peresunko²

2014

Buk. Med. Herald

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Population-level impact of switching to 1-dose human papillomavirus vaccination in high-income countries: examining uncertainties using mathematical modeling

Brisson,

Laprise,

Drolet

et al. 2024

JNCI Monographs

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Background A concern in high-income countries is that switching to 1-dose human papillomavirus (HPV) vaccination could cause a rebound in HPV infection and cervical cancer if 1-dose efficacy or duration were inferior to 2 doses. Using mathematical modeling and up-to-date trial-based data, we projected the population-level effectiveness of switching from 2-dose to 1-dose vaccination under different vaccine efficacy and duration assumptions in high-income countries. Methods We used HPV-ADVISE (Agent-based Dynamic model for VaccInation and Screening Evaluation), a transmission-dynamic model of HPV infection and cervical cancer, varying key model assumptions to identify those with the greatest impact on projections of HPV-16 and cervical cancer incidence over time: 1) 1-dose vaccine efficacy and vaccine duration, 2) mechanisms of vaccine efficacy and duration over time, 3) midadult (>30 years of age) sexual behavior, 4) progression to cervical cancer among midadults, and 5) vaccination coverage and programs. Results In high-income countries, 1-dose vaccination would cause no appreciable rebound in HPV-16 infection, except for a limited rebound under the most pessimistic assumptions of vaccine duration (average, 25 years), because 1) the switch would occur when HPV prevalence is low because of high 2-dose vaccination coverage and 2) individuals would be protected during their peak ages of sexual activity (<35 to 40 years of age). Our model projects a more limited rebound in cervical cancer because of a shift to older age at infection, resulting in fewer life-years left to potentially develop cancer. Projections were robust when varying key model assumptions. Conclusions High protection during peak ages of sexual activity in high-income countries would likely mitigate any potential rebounds in HPV infection and cervical cancer under the most pessimistic assumptions of 1-dose efficacy and duration.

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Cervical Cancer Incidence in Ontario Women: Differing Sociodemographic Gradients by Morphologic Type (Adenocarcinoma Versus Squamous Cell)

Cited by 3 publications

References 12 publications

Risk factors for the development of cervical cancer: analysis of the evidence

Risk factors for the development of cervical cancer: analysis of the evidence

Clinical features of adenocarcinoma of the cervix

Population-level impact of switching to 1-dose human papillomavirus vaccination in high-income countries: examining uncertainties using mathematical modeling

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