2016
DOI: 10.1111/tog.12279
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Cervical cancer prevention and screening: the role of human papillomavirus testing

Abstract: An organised screening programme has reduced the incidence of cervical cancer in the UK. Cervical screening aims to detect and treat premalignant, low-or high-grade disease. Oncogenic or high-risk human papillomaviruses (HR-HPV) account for over 99.7% of cervical cancer cases; the most common subtypes are 18,31, 33 and 45. HPV vaccination was introduced as part of the childhood vaccination programme in 2008 and will probably save 400 lives per year. HPV testing is useful: in triage of women with borderline or … Show more

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Cited by 30 publications
(21 citation statements)
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References 58 publications
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“…In this study, high dimensional classification problem was resolved by using decision tree methods because only those attributes were considered which showed highest relevance with the screening method (target class). The Hinslemann screening method showed high performance because Hinslemann is also traditional method of screening of cervical cancer which is effective [55][56][57]. The performance of biopsy screening method was slightly low from Hinslemann screening method.…”
Section: Resultsmentioning
confidence: 99%
“…In this study, high dimensional classification problem was resolved by using decision tree methods because only those attributes were considered which showed highest relevance with the screening method (target class). The Hinslemann screening method showed high performance because Hinslemann is also traditional method of screening of cervical cancer which is effective [55][56][57]. The performance of biopsy screening method was slightly low from Hinslemann screening method.…”
Section: Resultsmentioning
confidence: 99%
“…[3] Serviks kanseri-HPV ilişkisi Serviks kanserinin oluşumu için, insan papilloma virüsü (HPV) varlığı gereklidir, ancak yeterli değildir. [4] Bugün, servikal kanser gelişimi için HPV'nin mutlaka var olması gerektiği, diğer risk faktörlerinin ya virüsle karşılaşma oranını arttırdığı ya da viral persistansın karsinojenik süreci hızlandırmada önemli olduğu konusu üzerinde durulmaktadır. [5] Cinsel yönden aktif erişkinlerin %70'inden fazlası, hayatlarının bir döneminde HPV'ye maruz kalmakta ve bunların da %70'inden fazlasının 15-24 yaş arasında olduğu bildirilmektedir.…”
Section: öZunclassified
“…[10] HPV ile enfekte olmayan kadınlarda servikste skuamöz hücreli karsinom gelişme riski düşük iken, enfekte olanlarda bu risk 250-400 kat artmaktadır. [4] Genellikle cinsel aktivite sırasında anal bölge epitelinde meydana gelen travma sonucu, HPV bazal hücre tabakalarına yerleşir. Bazal hücreler çoğalır ve çekirdek içinde virüs replikasyonu gerçekleşir.…”
Section: öZunclassified
“…Human papillomavirus (HPV) infection is one of the STDs. It is classified as low-and high-risk infection respecting its neoplastic alterations (5,6). HPV infection is highly prevalent so that 20% of sexuallyactive adolescent girls are at risk for it (7,8).…”
Section: Introductionmentioning
confidence: 99%