Cervical cancer worldwide

Vu, Mailinh; Yu, Jim G.; Awolude, Olutosin; Chuang, Linus

doi:10.1016/j.currproblcancer.2018.06.003

Cited by 396 publications

(302 citation statements)

References 33 publications

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“…CESC is one of the frequently detected malignancies and pose a health threat to women all over the world [1][2][3]. Clinical stage, pathologic type, response to therapy and long-term prognosis can vary considerably among CESC patients.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of the recent global cancer statistics, there were 570,000 newly diagnosed CESC cases and 311,000 deaths in 2018 worldwide [2]. The incidence and mortality of CESC in developing countries still drastically continue to rise, and CESC tends to occur in younger women [3]. Clinically, surgical resection, chemotherapy and radiotherapy, alone or combined, sometimes may be effective when treating early-stage, focal, sensitive CESC [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive analysis of alternative splicing and transcriptome related to the prognosis of cervical squamous cell cancer

Yan

Chen

et al. 2020

Preprint

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Background: Cervical squamous cell cancer (CESC) is a common malignancy tumor with high incidence and mortality in women globally. Increasing studies have indicated that there was an indivisible association between alternative mRNA splicing (AS) and multiple types of cancer. However, comprehensive analysis of alternative mRNA splicing events is scarce in CESC. Methods: In this study, alternative mRNA splicing events data and clinical information of 216 CESC patients were downloaded from TCGA SpliceSeq database and TCGA website. We used identified survival-associated splicing events (SASEs) to construct prognostic signatures. Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curve were performed to evaluate the clinical value of prognostic signatures. A nomogram was carried out to quantitatively predict individuals’ survival probability. Regulatory network between splicing factors (SFs) and SASE was analyzed to explore the upstream regulators of a certain SASE. Additionally, we explored potential downstream pathways of a certain SASE. Results: A total of 41776 alternative splicing events in 9961 genes were collected. After sorting out SASEs, multivariable regression analysis was used to acquire 70 SASEs that could be independent prognostic factors for overall survival in CESC. Kaplan-Meier survival analyses showed that the difference was statistically significant (P＜0.01). The area under ROC curve (AUC) for all AS pattern was 0.932. A nomogram was constructed with a concordance index of 0.82 to predict individuals’ survival probability. EIF3A positively regulated SEC23A-27346-AP with highest correlation coefficient (P＜0.001, R=0.69). Besides, the most significant SASEs and KEGG pathways were SEC23A-27346-AP and adherens junction pathway (P=0.02, R=0.65). Conclusions: Prognostic signatures of survival-associated splicing events were independent prognostic factors for overall survival among CESC patients. A nomogram could quantitatively predict individuals’ survival probability. Moreover, we proposed that splicing factor EIF3A positively regulated SEC23A-27346-AP, and adherens junction pathway may be the downstream pathway of SEC23A-27346-AP. The aforementioned signaling pathway could play a crucial role in the development of CESC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of alternative splicing and transcriptome related to the prognosis of cervical squamous cell cancer

Yan

Chen

et al. 2020

Preprint

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“…miR-758 inhibits the migration and invasion of CC cells. Cell migration and invasion are critical events in tumor progression (12). Thus, Transwell assays were employed to assess the function of the miR-758 on the migration and invasion of CC cells.…”

Section: Mir-758 Inhibits the Proliferation Of CC Cells Via Hmgb3mentioning

confidence: 99%

MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway

2019

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Cervical cancer (CC) remains a highly prevalent cancer and cause of mortality amongst women worldwide. miR-758 has been demonstrated to be associated with tumorigenesis by controlling the expression of oncogenic or tumor suppressor genes. However, the function and mechanisms of miR-758 in CC have not been well illustrated. The present study aimed to dissect the effect of miR-758 on the proliferation, migration and invasion of CC cells and determine the potential underlying molecular mechanism of these effects. qPCR results revealed that the expression of miR-758 was significantly decreased in CC tissues and cell lines compared with that in normal tissues and normal cells. Results of CCK-8, colony formation and Transwell assays revealed that miR-758 overexpression markedly decreased cell viability, proliferation, invasion and migration. However, miR-758 inhibitors significantly increased viability, proliferation, invasion and migration. In the mechanism study, we demonstrated that high mobility group box 3 (HMGB3) was a direct target of miR-758, and HMGB3 overexpression rescued the viability, proliferation, invasion and migration of HeLa cells reduced by an miR-758 mimic. It was demonstrated that HMGB3 regulated the WNT/β-catenin signaling pathway under miR-758 regulation. In summary, these observations suggested that miR-758 is a tumor suppressor gene that can inhibit the metastatic phenotype of CC cells by negatively regulating HMGB3, which may present a path to novel therapeutic stratagems for CC therapy.

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“…Infection with high-risk human papillomavirus (HPV), especially HPV16 and HPV18, is the main etiologic risk factor for CC, and plays an important role in diagnostic tests [2]. Surgery is the main treatment method for CC in early stages while advanced-stage CC can be treated with radiotherapy, chemotherapy, or concurrent chemoradiation, thereby improving the survival rate of CC patients [3]. However, a considerable number of CC patients have poor prognosis due to metastasis or recurrence within two years after treatment [4].…”

Section: Introductionmentioning

confidence: 99%

Immune‐related Long Noncoding RNA Signature for Patients with Cervical Cancer

Zheng

Tong

Cao

et al. 2020

Preprint

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Background: Cervical cancer (CC) is a common gynecological malignancy for which prognostic and therapeutic biomarkers are urgently needed. The signature based on immune‐related lncRNAs(IRLs) of CC has never been reported. This study aimed to establish an IRL signature for patients with CC.Methods: The RNA-seq dataset was obtained from the TCGA, GEO, and GTEx database. The immune scores（IS）based on single-sample gene set enrichment analysis (ssGSEA) were calculated to identify the IRLs, which were then analyzed using univariate Cox regression analysis to identify significant prognostic IRLs. A risk score model was established to divide patients into low-risk and high-risk groups based on the median risk score of these IRLs. This was then validated by splitting TCGA dataset(n=304) into a training-set(n=152) and a valid-set(n=152). The fraction of 22 immune cell subpopulations was evaluated in each sample to identify the differences between low-risk and high-risk groups. Additionally, a ceRNA network associated with the IRLs was constructed.Results: A cohort of 326 CC and 21 normal tissue samples with corresponding clinical information was included in this study. Twenty-eight IRLs were collected according to the Pearson’s correlation analysis between immune score and lncRNA expression (P < 0.01). Four IRLs (BZRAP1-AS1, EMX2OS, ZNF667-AS1, and CTC-429P9.1) with the most significant prognostic values (P < 0.05) were identified which demonstrated an ability to stratify patients into low-risk and high-risk groups by developing a risk score model. It was observed that patients in the low‐risk group showed longer overall survival (OS) than those in the high‐risk group in the training-set, valid-set, and total-set. The area under the curve (AUC) of the receiver operating characteristic curve (ROC curve) for the four IRLs signature in predicting the one-, two-, and three-year survival rates were larger than 0.65. In addition, the low-risk and high-risk groups displayed different immune statuses in GSEA. These IRLs were also significantly correlated with immune cell infiltration. Conclusions: Our results showed that the IRL signature had a prognostic value for CC. Meanwhile, the specific mechanisms of the four-IRLs in the development of CC were ascertained preliminarily.

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Cervical cancer worldwide

Cited by 396 publications

References 33 publications

Comprehensive analysis of alternative splicing and transcriptome related to the prognosis of cervical squamous cell cancer

Comprehensive analysis of alternative splicing and transcriptome related to the prognosis of cervical squamous cell cancer

MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway

Immune‐related Long Noncoding RNA Signature for Patients with Cervical Cancer

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