Cervical carcinoma antigen: Distribution in neoplastic lesions of the uterine cervix and comparison to other tumor markers

Flint, Andrew; McCoy, J. Philip; Schade, William J.; Hofheinz, David A.; Haines, Harold G.

doi:10.1016/0090-8258(88)90047-9

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Immunohistochemical methods have demonstrated CEA in all cases of CIN and 71% of invasive carcinomas but absence in normal squamous and glandular epithelium [1]. In contrast, Flint et al [11] found that 31% of normal glandular cervical epithelium stained with anti-CEA antibody. Parallel immunohistochemical tests for CEA antibodies in low-grade CIN showed no differences regarding regression, persistence or progression of the lesions [15].…”

Section: Discussionmentioning

confidence: 99%

Serum Tumor Markers and Cervical Intraepithelial Neoplasia

Αγοραστός¹,

Zournatzi²,

Constantinidis³

et al. 2000

Geburtsh u Frauenheilk

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Objective: To investigate the relationship between the serum levels of the tumor markers squamous cell carcinoma antigen (SCC), carcinoma antigen (CA125) and carcinoembryonic antigen (CEA) and cytologic, colposcopic and histologic findings in women with cervical intraepithelial neoplasia (CIN). We also assessed whether a coefficient based on the three markers, namely the quotient (SCC CEA)/CA125, could detect women with histologically proven high-grade lesions missed by cytology or colposcopy. Materials and Methods: Ninety-eight women attending our Theodoros Agorastos, M. D.

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Section: Discussionmentioning

confidence: 99%

Serum Tumor Markers and Cervical Intraepithelial Neoplasia

Αγοραστός¹,

Zournatzi²,

Constantinidis³

et al. 2000

Geburtsh u Frauenheilk

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“…Clear cell ACs have been reported by some authors to show immunoreactivity for CEA,24,25,31 CA 19-9,23 and CA 125,~-~ ~~w hile other authors23.24,25.30,36 noted negative re-sults for CEA, PLAP, CA, and vimentin. In one study, squamous carcinomas of the cervix were uniformly positive for CEA 28. …”

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confidence: 97%

Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix

Costa

Kenny²,

Judd

1994

Int J Surg Pathol

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A series of 53 carcinomas of the uterine cervix with a component of glandular differentiation were identified and included 29 pure adenocarcinomas and 24 adenosquamous carcinomas. Cervical adenosquamous carcinomas were defined as glandular carcinomas mixed with a squamous carcinoma component. Cervical pure adenocarcinomas were classified into various Mullerian subtypes analogous to other portions of the female genital tract yielding 14 mucinous/endocervical, 11 serous, 2 clear cell, and 2 endometrioid adenocarcinomas. A panel of immunostains including monoclonal carcinoembryonic antigen (CEA-M), polyclonal carcinoembryonic antigen (CEA-P), CA 125, CA 19-9, placental alkaline phosphatase, and vimentin showed no association with histologic differentiation except for mucinous/endocervical subtype (7 of 11 CEA-M or CEA-P positive and 7 of 11 CA 19-9 positive). Recurrent disease in adenocarcinoma and adenosquamous carcinoma was associated with stage III or IV disease at presentation (P < .001), serous histology (P < .05), absence of strong CEA-M staining (P < .025), absence of strong CEA-P staining (P < 05), and presence of vimentin staining (P < .05). No association was found between survival and other histologic subtypes of adenocarcinoma (mucinous/endocervical, endometrioid, or clear cell), adenosquamous carcinoma, histologic grade, lymphatic invasion, age, or immunohistochemical staining for CA 125, CA 19-9, or placental alkaline phosphatase. When only stage I and II disease was considered, there was no correlation between histology or immunohistochemistry and outcome. Int J Surg Pathol 1(3): [181][182][183][184][185][186][187][188][189][190] 1994

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“…Benign morular (squamous) metaplasia is present. 83 of the cases showed 33 positive for monoclonal carcinoembryonic antigen (CEA-M),38 positive for polyclonal CEA (CEA-P),26 positive for placental alkaline phosphatase, 18 positive for CA 125, 29 positive for CA 19-9, 24 positive for vimentin, 60 positive for CK CAM 5.2, and 81 positive for cytokeratin AE 1 :3 (CK AE1/3). Immunohistochemical staining pattern varied from predominantly lumenal to predominantly cytoplasmic(Fig.…”

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confidence: 99%

Uterine Glandular Carcinoma

Costa¹,

Kenny²,

Judd³

1993

Int J Surg Pathol

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This study correlated the histologic and immunohistochemical features of cervical and endometrial glandular carcinomas (adenosquamous carcinoma [ADENSQ] and adenocarcinoma [AC] ) with clinical outcome. A series of 87 uterine glandular carcinomas (53 cervical, 33 endometrial, and 1 arising in both cervix and endometrium) were histologically classified into mullerian subtypes: 28 ADENSQ, 19 serous AC, 19 mucinous AC, 15 endometrioid AC, and 6 clear cell AC. Utilizing both nuclear and architectural features, 66 glandular carcinomas were high histologic grade (3) and 21 were low histologic grade (1 or 2). Immunohistochemical studies performed on 83 of the cases showed: 33 + for monoclonal carcinoembryonic antigen (CEA-M); 38 + for polyclonal CEA (CEA-P); 26 + for placental alkaline phosphatase; 18 + for CA 125; 29 + for CA 19-9; 24 + for vimentin; 60 + for cytokeratin CAM 5.2; and 81 + for cytokeratin AE 1 : 3. The following significant correlations were identified. ADENSQ histology was associated with CEA-M staining (P < .025), and mucinous histology was associated with CA 19-9 staining (P < .025). Cervical primary site was associated with ADENSQ histology (P < .001) and staining with CEA-M (P < .025) and CEA-P (P < .05). Endometrial primary site was associated with endometrioid histology (P < .001). Forty-five patients had recurrent disease, 30 patients were disease-free for more than 1 year, and 12 patients had insufficient follow-up evaluation. Recurrent disease was associated with stage III or IV tumors (P < .001), grade 3 histology (P < .001), serous differentiation (P < .001), invasion to at least the middle third of the myometrium (P < .001) and large size of residual tumor at hysterectomy (mean 3.9 cm versus 1.3 cm, P < .005). Disease-free survival was associated with endometrioid differentiation (P < .05), strong CEA-M staining (P < .001), CEA-P staining (P < .025), and CA 19-9 staining (P < .05). Considering only stage 1 and 2 patients, grade 3 histology ( P < .025), deep myometrial invasion (P < .01), and size (P < .05) were still associated with recurrence and strong CEA-M staining (P < .025) was still associated with disease-free survival. However, strong CEA-M staining, deep myometrial invasion, and size of tumor after hysterectomy were all associated with histologic grade. Considering just histologic grade 3 carcinomas in stage 1 and 2 patients, absence of strong CEA-M staining, deep myometrial invasion, and size of tumor was no longer associated with recurrent disease. Histologic grade was the only independent predictor of prognosis in stage I and II patients. Int J Surg Pathol 1 (1): [13][14][15][16][17][18][19][20][21][22][23][24] 1993

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Cervical carcinoma antigen: Distribution in neoplastic lesions of the uterine cervix and comparison to other tumor markers

Cited by 6 publications

References 20 publications

Serum Tumor Markers and Cervical Intraepithelial Neoplasia

Serum Tumor Markers and Cervical Intraepithelial Neoplasia

Adenocarcinoma and Adenosquamous Carcinoma of the Uterine Cervix

Uterine Glandular Carcinoma

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