Cervical carcinoma metastatic to the skull, heart, and lungs: Analysis for human papillomavirus DNA

Yanuck, Michael D.; Kaufman, Raymond H.; Woods, Kendra V.; Adler‐Storthz, Karen

doi:10.1016/0090-8258(91)90238-z

Cited by 15 publications

(9 citation statements)

References 20 publications

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“…The findings are in line with results from other authors who found identical HPV status in almost 100% of primary and metastatic tumors of cervical origin. 18,20 Nevertheless, there may be rare exceptions from this 34 and one report points toward the possibility of a higher rate of HPV positivity in independent lung tumors of patients with HPV-positive cervical cancers. 11 However, the data available to date suggest that HPV positivity very seldom gets lost in metastatic tumor seeds and that when HPV is present in the primary tumor a comparable HPV status is usually mandatory in the metastasis.…”

Section: Discussionmentioning

confidence: 90%

Molecular HPV Typing as a Diagnostic Tool to Discriminate Primary From Metastatic Squamous Cell Carcinoma of the Lung

Weichert

Schewe

Denkert

et al. 2009

American Journal of Surgical Pathology

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In this study, typing of human papilloma virus (HPV) was performed in squamous cell carcinomas of the lung (n=26) as well as putative primaries of head and neck (n=21) and female genital tract (n=5) of the same patients, to test whether additional information to discriminate lung primaries from metastases can be gained by a direct comparison of the HPV status in both tumors. In 3 (14.2%) patients with head and neck as well as lung squamous cell carcinoma, an identical HPV subtype could be detected in both tumors suggesting metastatic disease. In 9 (42.9%) cases, discordant HPV status strongly suggested secondary primaries of the lung. In the remaining 9 (42.9%) patients, no HPV was evident in either tumor. In all patients with carcinomas of the cervix uteri an identical HPV subtype was detected in the cervical and in the lung tumor. In conclusion, the results suggest HPV typing, a method routinely used in cervical biopsies for years, as a very useful diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung, which in our cohort in 57.1% of cases allowed for almost definite classification.

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Section: Discussionmentioning

confidence: 90%

Molecular HPV Typing as a Diagnostic Tool to Discriminate Primary From Metastatic Squamous Cell Carcinoma of the Lung

Weichert

Schewe

Denkert

et al. 2009

American Journal of Surgical Pathology

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“…In this case there would be obvious need for a sensitive screening test allowing com prehensive evaluation of many nodes. HPV DNA is a potential tumor cell marker in analyzing lymph nodes for genital cancer métastasés but reports on HPV DNA-negative métastasés of HPV DNA-positive cancers indicate some limitations [12,[15][16][17]. Previous data from our lab oratory indicate that extrachromosomal viral DNA may be lost to a large extent in the course of metastatic spread, which would reduce the sensitivity of HPV DNA detec tion assays in the case of episomal persistence [12].…”

Section: Discussionmentioning

confidence: 76%

“…This is suggested by experiments that suppressed tumorigenicity of cervical cancer cells in nude mice by the expression of E6/E7 antisense RNA inhibiting translation of E6 and E7 proteins [9]. The view is generally supported by the persistence and continued expression of HPV DNA in most lymph node mctastases of cervical cancers [10][11][12][13][14] although several reports de scribe some HPV-DNA-negative metastases of HPV 16-or HPV 18-positive, primary tumors [12,[15][16][17], which raises doubts in the necessity of E6/E7 expression for the maintenance of the malignant phenotype.…”

Section: Introductionmentioning

confidence: 94%

Human Papillomavirus DNA in Genital Cancers, Metastases, and Lymph Nodes

Beyer-Finkler

Girardi²,

Sillem³

et al. 1995

Intervirology

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To evaluate the utility of human papillomavirus (HPV) DNA as molecular marker for diagnostic screening of lymph nodes for cancer metastases, we examined 16 involved and 124 histologically cancer-free nodes of 34 patients with cervical, vulval, or vaginal carcinomas associated with HPV 6, 16, 18, 31, 33, 45, or X. All metastases of HPV-positive tumors contained viral DNA of the same type as the primary cancer but in one case the copy number of viral genomes was dramatically reduced. In a varying proportion of histologically normal nodes of 7 of 23 patients with HPV 16-positive cancers HPV 16 DNA was revealed by Southern blot hybridization and/or PCR. Histologic reevaluation showed a metastasis in one case. Three examples of tumor heterogeneity regarding physical state or copy number of viral DNA are presented. Tumor heterogeneity is discussed as possible explanation for apparently inconsistent results such as HPV-negative metastases of HPV-positive tumors.

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“…However, our findings do not support the hypothesis that apoptotic myxoma cells are related to HPV or EBV; there are even some similarities between HSV and HPV. [16][17][18][19][20][21][22][23] This investigation has several limitations. First, this retrospective study had a relatively small sample group.…”

Section: Discussionmentioning

confidence: 99%

“…19 In addition, the presence of the tumorigenic viruses, HSV and HPV, has been implicated to potentiate neoplastic conditions in mucin-enriched cornea and in conjunctiva. [20][21][22][23] HPV may play a major role in the development of rapidly progressive, multifocal transitional cell carcinoma in immunosuppressed patients. E6 and E7 genes of the oncogenic HPV-16 can be transfected into primary human myocardial fibroblasts, immortalizing them.…”

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confidence: 99%

Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein–Barr virus

et al. 2005

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Cardiac myxoma is the most common tumor of the heart, has a variable clinical presentation and immunohistochemical profile. Viral infections, such as herpes simplex virus, human papillomavirus (HPV), and Epstein-Barr virus (EBV), may play an important role in the causes of cardiac myxoma. This investigation will demonstrate caspase-3-dependent apoptosis in cardiac myxoma without HPV or EBV infection. This study included 15 patients with cardiac myxoma, who were treated with surgical excision of the lesion. Data were collected on detailed clinical parameters. Terminal deoxynucleotidyl transferase nick-end labeling assay, electrophoresis, and caspase-3 immunohistochemical studies were performed to characterize apoptosis. Genechip containing 39 subtypes was used to elucidate HPV; and polymerase chain reaction to detect LMP-1 gene of EBV. The patient population comprised of eight (53%) women and seven (47%) men. The mean age of patient participants was 45 years, with an age range of 30-70 years. All patient cases were sporadic myxomas rather than familial myxomas. The patient presentations included dyspnea (53%), asymptomatic (27%), stroke (7%), chest pain (7%), and fever (7%). All lesions were located in the left atrium. The individual patient cases of myxoma did not differ in location or clinical event in terms of pathological scores, such as vascular proliferation, inflammation, cellularity, hyaline, calcification, or thrombosis. Cardiac myxoma is characterized by apoptosis through caspase-dependent pathway. HPV or EBV was not detected in any of the study patient samples. In conclusion, no viral genomes of HPV or EBV were detected in these 15 patients. This study demonstrates that caspase-3-dependent apoptosis in cardiac myxoma is not dependent on concurrence of previous HPV and/or EBV infection.

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Cervical carcinoma metastatic to the skull, heart, and lungs: Analysis for human papillomavirus DNA

Cited by 15 publications

References 20 publications

Molecular HPV Typing as a Diagnostic Tool to Discriminate Primary From Metastatic Squamous Cell Carcinoma of the Lung

Molecular HPV Typing as a Diagnostic Tool to Discriminate Primary From Metastatic Squamous Cell Carcinoma of the Lung

Human Papillomavirus DNA in Genital Cancers, Metastases, and Lymph Nodes

Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein–Barr virus

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