Cervical Ganglioneuroma in a Four Year Old Boy

Chintalapudi, Deepthi Chandrika; Nerune, Savitri Mallikarjun; Patil, Vijaya; Arakeri, Surekha U

doi:10.21276/apalm.2590

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…Ganglioneuromas (GNs) are benign slow-growing tumors of ganglion cells with the origin of migrated neural crest cells. They was first described by Loretz in 1870 and in cervical region by De Quervain in 1899 [14]. According to the International Neuroblastoma Pathology Classification (INPC), peripheral neuroblastic tumors (pNT) are classified into 3 major classes, namely, neuroblastomas (NB), ganglioneuroblastomas (GNB with 2 subclasses as nodular (GNB-N) and intermix (GNB-I)), and ganglioneuromas (GN).…”

Section: Discussionmentioning

confidence: 99%

“…Spinal ganglion involvement has presented in different ages, genders, and presenting patterns [10,11,15]. Extraspinal GNs generally present with palpabale masses beside clinical and paraclinical findings of cathecolamin overproduction [14][15][16]. Spinal GNs are derived from dorsal root ganglia and grow with different patterns.…”

Section: Discussionmentioning

confidence: 99%

“…When becoming an IDEM tumor, spinal GNs are of rare differential diagnosis in comparison to meningiomas, nerve sheath tumors, lipomas, lymphomas, and such. A number of studies have shown diffusion weighted imaging (DWI) to be helpful in differentiating GNs from nerve sheath tumors, with schwannomas having higher apparent diffusion coefficient value than GNs [9]; yet surgical resection-especially when symptomatic-is the most acceptable modality of choice for management of an IDEM tumor including GNs [14,[16][17][18]. There also seems to be a similar female predominance between spinal dumbbell GNs and extraspinal types.…”

Section: Discussionmentioning

confidence: 99%

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Resection of Bilateral Symmetrical Multiple Level Cervical Ganglioneuroma in a 43-Year-Old Man, a Probable Case of Neurofibromatosis Type-1: Report of a Case and Review of Literature

Mousavi

Motlagh

Karimi

et al. 2022

Case Reports in Surgery

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Ganglioneuroma is a benign tumor, originating from sympathetic nervous system. Intradural and dumbbell shape spinal ganglioneuroma has been reported in the literature. In this study, we intend to present our case, a 43-year-old man with multiple cutaneous dimples—probably a Neurofibromatosis type-1 (NF-1) case—and subacute myelopathy, who presented with bilateral symmetric dumbbell shape C2/C3 and C4/C5 intradural extramedullary tumors. After resection, the pathologic feature was revealed as ganglioneuroma. We also reviewed the literature for similar cases, which revealed our case to be the 9th bilateral and symmetrical spinal GN, all of which in cervical region; the 5th involving multiple level (the 3rd multiple bilateral symmetrical involvement), the 3rd extending intradurally, and the first case of involving all cervical nerve root ganglions in different sizes. Bilateral symmetrical spinal GNs have also appeared to have different body location, geographic, and gender distribution.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Resection of Bilateral Symmetrical Multiple Level Cervical Ganglioneuroma in a 43-Year-Old Man, a Probable Case of Neurofibromatosis Type-1: Report of a Case and Review of Literature

Mousavi

Motlagh

Karimi

et al. 2022

Case Reports in Surgery

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Neck Ganglioneuroma Mimicking a Thyroid Nodule in a Four-Year-Old Child: A Case Report and Review of the Literature

Corrado

Morgante

Tassi

et al. 2023

Int J Endocrinol Metab

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Introduction: Ganglioneuromas are tumors of neurogenic origin usually located in the abdomen, the adrenal glands, and the mediastinum but infrequently found in the neck region. Case Presentation: We describe the case of a four-year-old Albanian girl presenting with an anterior neck mass initially suspected to be a thyroid nodule. From a clinical point of view, there was no evidence of compression on vital cervical structures. Lab tests detected normal serum thyrotropin, calcitonin, and parathormone concentrations. A neck ultrasound showed a huge mass apparently originating from the left thyroid lobe. Cytological examination of fine needle biopsy demonstrated a population of large cells with eosinophilic cytoplasm, regular nuclei, and prominent nucleoli and spindle cells without significant atypia, consistent with a benign lesion of neurogenic origin. Also, the neck MRI displayed a mass with well-defined margins, likely arising from the peripheral nervous system. The patient underwent surgical excision of the mass without complications. The histological exam was diagnostic for ganglioneuroma. Conclusions: We discuss the cytological and histological features peculiar to such a rare neck lesion and review the differential diagnosis.

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Cervical Ganglioneuroma in a Four Year Old Boy

Cited by 2 publications

References 4 publications

Resection of Bilateral Symmetrical Multiple Level Cervical Ganglioneuroma in a 43-Year-Old Man, a Probable Case of Neurofibromatosis Type-1: Report of a Case and Review of Literature

Resection of Bilateral Symmetrical Multiple Level Cervical Ganglioneuroma in a 43-Year-Old Man, a Probable Case of Neurofibromatosis Type-1: Report of a Case and Review of Literature

Neck Ganglioneuroma Mimicking a Thyroid Nodule in a Four-Year-Old Child: A Case Report and Review of the Literature

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