Objective
The objective of this study was to assess for the presence of newly acquired preterm birth (PTB) risk factors among primiparous women with no prior history of PTB.
Design
Case-control study.
Setting
Deliveries occurring within a large healthcare system from 2002–2012
Population
Women with their first two consecutive pregnancies carried to ≥20 0/7 weeks gestation.
Methods
Those delivering the first pregnancy at term and the second preterm ≥20 0/7 and < 37 0/7 weeks (term-preterm cases) were compared to women with a term birth in their first two pregnancies (term-term controls). Social factors with the potential to change between the first and second pregnancies and intrapartum labour characteristics in the first pregnancy were compared between cases and controls.
Main outcome measures
Risk factors for term-preterm sequence.
Results
38215 women met inclusion criteria. 1,353 (3.8%) were term-preterm cases. Cases and controls were similar with regards to race/ethnicity and maternal age at the time of the first and second deliveries. Cases delivered their second pregnancy approximately three weeks earlier (35.7 vs. 39.1, p<0.001). In multivariable models accounting for known PTB risk factors, women with a caesarean delivery in the first pregnancy (aOR=2.20; 95% CI 1.57–3.08), new tobacco use (aOR=2.33; 95% CI, 1.61–3.38), and an interpregnancy interval < 18 months (aOR=1.37; 95% CI, 1.21–1.55) were at increased risk of term–preterm sequence.
Conclusion
Caesarean delivery in the first pregnancy, new tobacco use, and short interpregnancy interval < 18 months are significant risk factors for term-preterm sequence. Women should receive postpartum counseling regarding appropriate interpregnancy interval and tobacco cessation.