Cervical intraepithelial neoplasia in patients with breast cancer: a cytological and colposcopic study

Abstract

Summary Twenty-six patients with treated breast cancer who had been randomised previously to receive combination chemotherapy including alkylating agents (n = 14) or to undergo oophorectomy (n = 12) following surgery underwent cytological and colposcopic screening of the uterine cervix. Colposcopically directed cervical punch biopsies were taken from all patients in whom a colposcopic abnormality was detected. Breast cancer patients were compared with 79 controls with normal cervical cytology and no known breast malignancy. Colposcopically directed punch biopsies were taken from the cervical transformation zone of all controls. Significantly more breast cancer patients who had received chemotherapy (43%) than controls (10%) had CIN (P<0.01) and significantly more patients who had received chemotherapy (14%) than controls (3%) had CIN 2 or 3 (P <0.05).

Multifocal reversible epithelial dysplasia mimicking carcinoma in situ after conditioning therapy with busulfan and cyclophosphamide

“…1,2 We report a patient who developed reversible multifocal epithelial cell changes after conditioning therapy with busulfan and cyclophosphamide followed by autologous peripheral stem cell transplantation for AML.…”