Cervical langerhans cell histiocytosis mimicking cervical tuberculosis

Rao, Jingcheng; Wang, Chong; Cai, Yuqiang; Cao, Guangwen

doi:10.1097/md.0000000000015690

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Cervical TB can be challenging to diagnose owing to the wide differential available. For instance, cervical Langerhans cell histiocytosis is rare but very similar in clinical and radiological presentation to cervical TB as it may also be complicated by vertebral destruction and abscess formation [ 5 ]. Lymphoma is another condition that may affect the cervical spine in which T2 sagittal MRI cervical spine exhibits vertebral destruction [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Isolated Tuberculosis of the Cervical Vertebrae

Mahmoud¹,

Abdelhay²,

Eltaher³

et al. 2023

Cureus

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Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs, but extrapulmonary affection can occur with lymphatic or hematogenous spread. Skeletal affection commonly involves the spine, but cervical vertebral affection is rare. We report a 23-year-old female patient who presented to the hospital with diffuse limb weakness and neck pain as the only complaints. MRI of the cervical spine revealed a peripherally enhancing lesion arising from the posterior aspects of the cervical vertebrae with compressive myelopathy. She underwent surgical decompression and was noted to have caseous drainage during the procedure. She was started promptly on anti-tuberculous therapy after she had a positive interferon-gamma release assay. Late culture results confirmed isolated cervical TB of the vertebrae as the diagnosis. Prompt awareness and initiation of treatment for vertebral TB are necessary as clinical presentation can mimic other infectious and malignant etiologies.

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Section: Discussionmentioning

confidence: 99%

Isolated Tuberculosis of the Cervical Vertebrae

Mahmoud¹,

Abdelhay²,

Eltaher³

et al. 2023

Cureus

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Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Reisi

Raeissi

Khalilabad

et al. 2021

Orphanet J Rare Dis

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Background Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells. Dendritic cells are a type of histiocyte that play an important role in the human immune system and are found in the bone, skin, stomach, eyes, intestines, and lungs. Objective This systematic review aimed to collect and report published case reports of rare bone disease caused by LCH to avoid misdiagnoses or delays in diagnosis. Methods We systematically searched Scopus, PubMed, Embase, and Web of Sciences from August 1, 2000 to December 31, 2019. Studies reporting cases of LCH with rare bone involvement were included. Results We identified 60 articles including 64 cases. Of the identified cases, 31 (48.4%) involved children, and 33 (51.6%) involved adults. Additionally, 46.9% (30 individuals) were from Asian countries. The mean age of the children was 7.6 ± 4.3 years and that of the adults was 36 ± 12 years. The findings indicated that unifocal bone involvements were the most prevalent form of the disease (68.7%), and, overall, the skull and chest wall were the most commonly affected bones in both adults and children. The spine and long bones were the second most commonly affected bones in children, and the spine and jaw were the second most commonly affected bones in adults. Pain and swelling were the most frequent presenting signs among the investigated cases, and loss of consciousness, myelopathy, nerve palsy, visual loss, torticollis and clicking sounds were rare signs. Osteolytic lesions were the most frequent radiologic feature (62.5%), and intracranial hemorrhage, fluid–fluid level, dura and intracranial extension and pathologic fractures were rare radiological features. Total excision, curettage and observation in the unifocal group of patients and systemic chemotherapy in the other groups (i.e., multifocal and multisystem) were the most frequent management approaches. The recovery rates of the unifocal and multifocal groups were 77.3% and 81.8%, respectively, while that of the multisystem group was 55.5%. The rates of recurrence and mortality in the multisystem group were 11% and were higher than those in the other groups. Conclusions LCH is a rare disease that can affect any organ in the human body. However, bone is the most commonly involved organ, and rare bone involvements may be the first or only symptom of the disease due to the rarity of such lesions; a lack of familiarity with them may result in misdiagnosis or delayed diagnosis.

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Langerhans cell histiocytosis: unusual dorsal spine localization in an adult male

et al. 2023

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This case report describes the clinical, imaging, and pathological features of a case of Langerhans cell histiocytosis affecting a patient suffering from chronic thoracic spine pain. Spinal localizations of Langerhans cell histiocytosis have been rarely described and they are usually characterized by involvement of vertebral bodies with osteolytic lesions. Our case presented with several unusual features that delayed the diagnosis, including the age of patient and the involvement of left T10 costovertebral junction with relative sparing of vertebral body and costal bone. The clues for diagnosis were represented by increased signal intensity both on T2W fat-saturated and T1W images after administration of gadolinium. The diagnosis was finally confirmed by means of percutaneous biopsy with subsequent histological/immunohistochemical study.

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Cervical langerhans cell histiocytosis mimicking cervical tuberculosis

Cited by 3 publications

References 22 publications

Isolated Tuberculosis of the Cervical Vertebrae

Isolated Tuberculosis of the Cervical Vertebrae

Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Langerhans cell histiocytosis: unusual dorsal spine localization in an adult male

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