“…This study represents a nested study analysis from a prospective cohort study evaluating the relation between SRCs at 24 and 28 weeks and preterm labor, which enrolled mid-trimester women of all parity with singleton fetuses of gestational age confirmed by ultrasound (10).…”
In contrast to previous reports, mid-gestation relaxin tended to be higher and fall significantly faster in women with PFD. Acknowledging relaxin's effects on collagen turnover, our findings explore the association between childbirth and PFD.
“…This study represents a nested study analysis from a prospective cohort study evaluating the relation between SRCs at 24 and 28 weeks and preterm labor, which enrolled mid-trimester women of all parity with singleton fetuses of gestational age confirmed by ultrasound (10).…”
In contrast to previous reports, mid-gestation relaxin tended to be higher and fall significantly faster in women with PFD. Acknowledging relaxin's effects on collagen turnover, our findings explore the association between childbirth and PFD.
“…15 It appears that even screening the general obstetric population using transvaginal ultrasound is unlikely to be helpful, as a cohort study of the general population of singleton pregnant women found that cervical length measurement of </= 30 mm had a positive predictive value of only 4.5% for preterm birth. 22 It appears that in singleton gestations, ultrasoundindicated cervical cerclage may be more efficacious in those women with a higher risk obstetrical features such as prior preterm delivery or prior second-trimester loss. Future research should focus on this subgroup of women in order to increase sample sizes and demonstrate treatment effect with better precision.…”
Preterm birth remains one of the most important predictors of fetal morbidity and mortality. Measurement of cervical length by transvaginal ultrasound in the second trimester has been proposed as an effective screening tool in women at high risk of preterm birth and cervical cerclage has been used for over 50 years as a method of preventing preterm delivery related to cervical insufficiency. This review examines the evidence of the effectiveness of therapeutic cerclage following measurement of short cervix on transvaginal ultrasound in preventing preterm birth. Patient populations in which ultrasound-indicated cerclage has been demonstrated to have unique benefit were identified and implications for future research are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.