Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors

Spinelli, Claudio; Tognetti, Francesco; Strambi, Silvia; Morganti, Riccardo; Massimino, Maura; Collini, Paola

doi:10.1007/s00268-018-4487-z

Cited by 47 publications

(46 citation statements)

References 67 publications

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“…In many studies, the association between male and CLNM were signi cant [22]. However, Spinelli et al [23] reported no signi cant correlation. In our study, ratio of female /male ratio was 1:3, which was consistent with previous studies [2].…”

Section: Discussionmentioning

confidence: 98%

“…Our data revealed that patients aged <55 years were more prone to LNM and NMLNs >5 and ten-year age was an independent predictor for the low prevalence of LNM and NMLNs >5. However, Spinelli et al [23] retrospectively discussed the clinical characteristics of 132 children and adolescents with PTC and found that age was not related to LNM. These results vary from ours due to difference in the target population.…”

Section: Discussionmentioning

confidence: 99%

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WITHDRAWN: The Clinical and Prognosis Value of the Number of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma Patients

Zhan

Feng

et al. 2020

Preprint

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Objective: It has been reported that papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) are more associated with adverse outcomes. This study aimed to assess the correlation between the lymph node (LN) status and clinical prognosis in PTC patients. Methods: We retrospectively reviewed the medical records of PTC patients who underwent initial thyroid cancer surgery in Renmin Hospital of Wuhan University between 2017 and 2019. 1021 PTC patients with total checked number of lymph nodes ≥5 were involved in this study. The clinicopathological characteristics of patients were compared according to the LN status and the number of metastatic lymph nodes (NMLNs). Results: The LNM and NMLNs>5 were seen in 694 (68.0%) and 222 (21.7%) cases, respectively. Young patients, patients with larger tumor diameter, bilaterality, multifocality and gross extrathyroidal extension (ETE) were more inclined to LNM and NMLNs >5 (P<0.001). The patients with LNM (pN1) were mainly among males and were exhibited multifocality and advanced tumor stage (P<0.001), while pN1 patients with NMLNs >5 were negatively associated with advanced tumour stage (P<0.05). Recurrence-free survival among pN1 patients was significantly different between 2 groups (NMLNs ≤5: 0/472, 100.0%; NMLNs >5: 5/222, 97.7%; P=0.002). In multivariate logistic regression analysis, the male (OR=2.580, P<0.001), 10-mm tumor size (OR=1.770, P<0.001), tumor gross ETE (OR=2.004, P<0.001) were independent predictors for the high prevalence of LNM. Similarly, 10-mm tumor size (OR=1.399, P<0.05), bilaterality (OR=2.350, P<0.001) and tumor gross ETE (OR=2.660, P<0.05) were also independent predictors for the high prevalence of NMLNs >5; 10-year age was an independent predictor for the low prevalence of the LNM (OR=0.658, P<0.001) and NMLNs >5 (OR=0.678, P<0.001). Conclusions: The status of the cervical LNs and the NMLNs should be correctly evaluated to guide reasonable treatment and careful follow-up.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: The Clinical and Prognosis Value of the Number of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma Patients

Zhan

Feng

et al. 2020

Preprint

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“…Therefore, the treatment approach for this disease is changing. In recent years, prophylactic CCND has not been recommended for PTMC patients without LNM . The median risk of local‐regional lymph node recurrence varies markedly by clinical staging in patients with pathologically proven neck LNM, with recurrence rates of 2% (range 0%‐9%) in patients with an initial N0 stage vs 22% (range 10%‐42%) in those with initially positive lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, prophylactic CCND has not been recommended for PTMC patients without LNM. 8,[22][23][24][25] The median risk of local-regional lymph node recurrence varies markedly by clinical staging in patients with pathologically proven neck LNM, with recurrence rates of 2% (range 0%-9%) in patients with an initial N0 stage vs 22% (range 10%-42%) in those with initially positive lymph nodes. Furthermore, the median risk of recurrence in LNM patients varies markedly by the number of positive…”

Section: Discussionmentioning

confidence: 99%

“…The presence of multifocality and capsular infiltration indicates a high risk of cancer invasion and metastasis. 25,26 Therefore, cases with a single tumor in the thyroid parenchyma and within the thyroid capsule were eligible for RFA in this study. Our preliminary study showed that RFA is efficient with a low complication rate in PTMC treatment.…”

Section: T a B L E 3 Changes In The Tumormentioning

confidence: 99%

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Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound‐guided radiofrequency ablation for papillary thyroid microcarcinoma

Zhang

Luo

et al. 2019

Cancer Medicine

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Background Chronic lymphocytic thyroiditis (CLT) is an autoimmune disease commonly associated with papillary thyroid carcinoma characterized by a smaller primary tumor size at presentation. The efficacy and safety of ultrasound‐guided radiofrequency ablation (RFA) for papillary thyroid microcarcinoma (PTMC) coexisting with CLT is still unknown. Methods Sixty patients with unifocal PTMC were enrolled and classified into PTMC and PTMC+CLT groups (n = 30/group). CLT was diagnosed histopathologically. The ablation area exceeded the tumor margins, and was evaluated by US and contrast‐enhanced US (CEUS) for residual tumor to prevent recurrence. Three months after ablation, US‐guided core‐needle biopsy was performed to assess the presence of residual and recurrent cancer. Preoperative and postoperative data on patients and tumors were recorded and analyzed. Results There were no differences between groups in age, sex, preoperative tumor volume, ablation time, or ablation power (P > 0.05). There was also no significant difference in postoperative ablation zone volume between the groups at the 1‐, 3‐, 6‐, 12‐, and 18‐month follow‐ups (P > 0.05). The volume reduction rate significantly differed between the two groups at month 3 (P = 0.03). The ablation area could not be identified on US and CEUS at 9.8 ± 5.0 and 10.0 ± 4.8 months in the PTMC and PTMC + CLT groups, respectively (P = 0.197). No serious complications occurred during and after ablation. No residual cancer cells were found on biopsy after ablation. Conclusions RFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT.

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Risk factors associated with preferential lateral lymph node metastasis in papillary thyroid carcinoma

Shao,

Wang,

Dong

et al. 2023

Cancer Medicine

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BackgroundLateral lymph node metastasis (LLNM) is common in patients with papillary thyroid cancer (PTC), usually occurring after central lymph node metastasis (CLNM). However, some patients experience LLNM without first developing CLNM. This study aimed to identify the risk factors for developing LLNM without CLNM.MethodsWe retrospectively reviewed 421 patients diagnosed with PTC who underwent lobectomy or total thyroidectomy with central and ipsilateral lateral lymph node dissection. We collected clinicopathological data and used univariate and multivariate logistic regression analyses to determine the risk factors associated with LLNM without CLNM.ResultsThe LLNM without CLNM frequency was 18.3% (77/421). Univariate analyses demonstrated that age over 55 years, primary tumor in the upper portion of the thyroid, the number of central lymph node (CLN) and LLNM, primary tumor size, and the summed size of multi‐foci tumors smaller than 1 cm were significantly associated with LLNM without CLNM (p < 0.05). Multivariate analysis revealed that LLNM without CLNM was more likely to occur in patients aged ≥55 years (odds ratio [OR], 2.309; 95% confidence interval [CI], 1.133–4.704; p = 0.021), and primary tumor in the upper portion of the thyroid (OR, 0.524; 95% CI, 0.295–0.934; p = 0.028).ConclusionThe lymph node metastasis pattern in patients with PTC is not constant. Therefore, surgeons should evaluate the lateral lymph nodes, especially in patients older than 55 years or when the primary tumor is in the upper portion of the thyroid.

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Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors

Cited by 47 publications

References 67 publications

WITHDRAWN: The Clinical and Prognosis Value of the Number of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma Patients

WITHDRAWN: The Clinical and Prognosis Value of the Number of Metastatic Lymph Nodes in Papillary Thyroid Carcinoma Patients

Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound‐guided radiofrequency ablation for papillary thyroid microcarcinoma

Risk factors associated with preferential lateral lymph node metastasis in papillary thyroid carcinoma

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