Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Hellquist, Henrik; Skálová, Alena; Barnes, Leon; Cardesa, Antonio; Thompson, Lester D.�R.; Triantafyllou, Asterios; Williams, Michelle D.; Devaney, Kenneth O.; Gnepp, Douglas R.; Bishop, Justin A.; Wenig, Bruce M.; Suárez, Carlos; Rodrigo, Juan P.; Coca‐Pelaz, Andrés; Strojan, Primož; Shah, Jatin P.; Hamoir, Marc; Bradley, Patrick J.; Silver, Carl E.; Slootweg, Pieter J.; Poorten, Vincent Vander; Teymoortash, Afshin; Medina, Jesús E.; Robbins, K. Thomas; Pitman, Karen T.; Kowalski, Luiz Paulo; Bree, Remco de; Mendenhall, William M.; Eloy, Jean Anderson; Takes, Robert P.; Rinaldo, Alessandra; Ferlito, Alfio

doi:10.1007/s12325-016-0298-5

Cited by 65 publications

(54 citation statements)

References 50 publications

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“…High grade transformation (or dedifferentiation), defined as severe nuclear atypia, brisk mitotic activity, prominent necrosis, and loss of the biphasic ductal-myoepithelial differentiation, has been reported in ACC (28, 36, 37). Although, distinguishing solid ACC from ACC with HGT might be sometimes challenging, the aggressive histologic features of solid ACC in general appear to be extensive and exaggerated in ACC with HGT compared to solid ACC.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Outcome in Adenoid Cystic Carcinoma of Salivary Glands

Xu¹,

Drill

et al. 2017

American Journal of Surgical Pathology

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Adenoid cystic carcinoma (ACC) is the second most common salivary gland malignancy and it has a high rate of recurrences and a poor long term prognosis. Our aim was to assess the prognostic factors in ACC and study MYB-NFIB fusion and MYB protein expression in a large retrospective cohort of 135 patients with a median follow up of 6.3 years. The 5-year and 10-year local recurrence-free survival rate of 94% and 78%, 5-year and 10-year distant metastasis survival rate of 77% and 58%, and 5-year and 10-year recurrence free survival (RFS) of 66% and 44%. The following features were identified as adverse prognostic factors of RFS on univariate analysis: large tumor size, solid growth pattern, increased mitoses, positive margin, AJCC clinical staging, high grade transformation, vascular invasion, nuclear atypia, open chromatin, prominent nucleoli, and tumor necrosis. However, on multivariate analysis, only increased mitoses (≥5/10 high power fields), any solid growth pattern, and advanced AJCC TNM staging were independent adverse predictors for RFS. MYB immuno-expression and MYB-NFIB translocation were common findings in ACC, occurring in 72% and 59% of the tested ACCs, respectively. The sensitivity and specificity of MYB immunohistochemistry in detecting MYB-NFIB fusion was relatively low at 78% sensitivity and 50% specificity. The high prevalence of alterations leading to high expression of the MYB transcription factor family suggests that targeted approaches developed to suppress the expression of these oncogenic transcription factors and/or the transcriptional activity of these proteins would be a rational therapeutic approach to investigate in ACC.

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Section: Discussionmentioning

confidence: 99%

Predictors of Outcome in Adenoid Cystic Carcinoma of Salivary Glands

Xu¹,

Drill

et al. 2017

American Journal of Surgical Pathology

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“…Adenoid cystic carcinoma is a malignancy of the salivary glands with a mean survival of 4.3 years and 43–57% of patients present with lymph node metastasis 1. d-ACC is a rare variant with high-grade transformation and is reported in only 40 case reports worldwide 1 2…”

Section: Descriptionmentioning

confidence: 99%

“…d-ACC is a rare variant with high-grade transformation and is reported in only 40 case reports worldwide 1 2…”

Section: Descriptionmentioning

confidence: 99%

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Dedifferentiated adenoid cystic carcinoma of the nasopharynx: a rare entity of head and neck cancer

et al. 2016

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DESCRIPTIONA 45-year-old man whose parents emigrated from Hong Kong presented with a 2-year history of recurrent epistaxis, neck lump and worsening vision. He had never smoked.Baseline ophthalmology assessment confirmed left vision loss to finger-counting. Infection screens including retroviral, hepatitis and Epstein-Barr virus were negative. A positron emission tomography scan revealed nasopharyngeal mass with direct invasion into bilateral orbital fossae and bilateral neck nodes (figures 1A and 2A). An incisional biopsy performed under general anaesthesia confirmed dedifferentiated adenoid cystic carcinoma (d-ACC) stage cT4N2cM0 (figure 3).Multimodality treatment was recommended. He was started on neoadjuvant triplet chemotherapy docetaxel (75 mg/m 2 ), cisplatin (75 mg/m 2 ) and fluorouracil (750 mg/m 2 ) (TPF regime) for three cycles. Reassessment with imaging showed good partial response and therefore he was treated with radical chemoradiotherapy (Tomotherapy 65 Gy in 30 fractions with synchronous Cisplatin).Post-treatment functional imaging confirmed complete remission in the primary and left-sided neck node with minimal uptake of uncertain

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“…Neck lymph node metastasis is the most common way of tumor metastasis in HNSCC. Approximately 50% patients with HNSCC have occult or obvious cervical lymph node involvement at diagnosis . Although surgical treatment, radiation therapy, and chemotherapy have improved significantly, the overall survival rate of the people with the disease has not improved significantly over the past 20 years.…”

Section: Introductionmentioning

confidence: 99%

MiR‐143‐3p suppresses cell proliferation, migration, and invasion by targeting Melanoma‐Associated Antigen A9 in laryngeal squamous cell carcinoma

Liang

Tang

et al. 2018

J of Cellular Biochemistry

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Previously we found that melanoma‐associated antigen‐A9 (MAGE‐A9) was a significantly upregulated biomarker in laryngeal squamous cell carcinoma (LSCC). A high expression of MAGE‐A9 indicates an unfavorable survival outcome, and the MAGE‐A9 expression level is an independent prognostic factor of LSCC. To explore the mechanism of MAGE‐A9 upregulation, several predicted regulatory microRNAs were screened and validated in LSCC cells. In the current study, we found that miR‐143‐3p (MAGE‐A9 related miRNAs) expression levels correlated negatively with the MAGE‐A9 protein expression in LSCC tissues. Dual‐luciferase reporter assays and Western blot analysis revealed MAGE‐A9 to be a direct target of miR‐143‐3p. Furthermore, a series of in vitro gain‐ and loss‐of‐function assays revealed that miR‐143‐3p inhibited LSCC cell proliferation, migration, and invasion. Also, miR‐143‐3p suppressed LSCC tumorigenesis in vivo. These effects were clinically relevant, as a lower expression of miR‐143‐3p occurred in severer clinical stages and represented poor overall survival in patients with LSCC. Taken together, these results suggest that downregulation of miR‐143‐3p contributes to tumor progression through upregulation of MAGE‐A9. The expression level of these two key molecules maintained LSCC progression, thus, highlighting the potential of miR‐143‐3p as a therapeutic target for human LSCC.

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Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Cited by 65 publications

References 50 publications

Predictors of Outcome in Adenoid Cystic Carcinoma of Salivary Glands

Predictors of Outcome in Adenoid Cystic Carcinoma of Salivary Glands

Dedifferentiated adenoid cystic carcinoma of the nasopharynx: a rare entity of head and neck cancer

MiR‐143‐3p suppresses cell proliferation, migration, and invasion by targeting Melanoma‐Associated Antigen A9 in laryngeal squamous cell carcinoma

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