Cervical lymphadenopathy: metastasis of papillary carcinoma or ectopic thyroid tissue?

Simion, Nicolae Irinel; Muntean, Valentin

doi:10.1136/bcr.01.2012.5603

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…11,12 The focal hypermetabolic lesion seen in the current case-which is typical of primary esophageal cancer but not PTC-constituted a factor contributing to a misdiagnosis. 13,14 The FDG PET manifestation in this case reminds us the possibility of differential diagnosis between ectopic PTC within the esophagus and esophageal cancer.…”

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confidence: 70%

Ectopic Papillary Thyroid Carcinoma Mimicking Esophageal Cancer in FDG PET

Gao

Jia

et al. 2019

Clin Nucl Med

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Ectopic papillary thyroid carcinoma (PTC) usually occurs along the cervical midline and was barely reported in FDG PET studies. We present a rare case of ectopic PTC within the esophagus with focal FDG activity on FDG PET in a 43-year-old woman who was previously diagnosed as having esophageal cancer based on the endoscopy and PET findings. Surgical pathology revealed the presence of PTC lesion within the muscular layer of the esophagus. Combining this with the negative imaging and laboratory results suggesting a normal thyroid gland led to a diagnosis of primary ectopic PTC.

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confidence: 70%

Ectopic Papillary Thyroid Carcinoma Mimicking Esophageal Cancer in FDG PET

Gao

Jia

et al. 2019

Clin Nucl Med

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“…Thyroidectomy accompanied by neck dissection of the ipsilateral side and followed by adjuvant radioactive iodine therapy has been proposed by Simion et al . 27 .…”

Section: Discussionmentioning

confidence: 99%

An unprecedented occurrence of incidental tonsillar ectopic primary Papillary Thyroid Carcinoma in an adult female: A case report

Khalek

Laham

Abazid

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Any defect in the early phases of the normal complex embryogenic pathway might lead to anatomical anomalies that lead to the formation of ectopic thyroid gland tissue. Overall, ectopic thyroid tissue incidence is one in 300 000, and the rate of malignant transformation among those is merely 1%. However, documented cases of malignant transformation of ectopic thyroid tissue in the tonsils have not yet been – to the best of the knowledge – documented in published literature. Case Presentation: We illustrate the case of a 58-year-old female who was referred to the clinic after she underwent a tonsillectomy due to chronic discomfort and gradual difficulty in swallowing. Documentation of an ectopic primary Papillary Thyroid Carcinoma in one of the patient’s excised tonsils was achieved after thorough histopathological and immunohistochemical analyses took place. Radiological evaluation excluded any metastatic involvement and paved the path toward surgical intervention, which was comprised of a total thyroidectomy. Clinical Discussion: Surgical resection of the patient’s thyroid gland was achieved, and the subsequent histopathological analysis of the specimens revealed nodular hyperplasia with degenerative changes but without evidence of malignant transformation in her thyroid gland. Conclusion: Ectopic primary Papillary Thyroid Carcinoma is an immensely rare occurrence, regardless of population parameters. Its incidence could originate in various anatomical locations, but to the best of the knowledge, its incidence in the tonsils has not been previously documented in published literature. Adequate levels of clinical awareness in this situation could timely alleviate patient complaints and aid in performing optimal life-saving interventions.

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“…In the case of primary carcinoma of ectopic thyroid tissue, regarding the lack of data, there are no evidence-based guidelines on the optimal treatment [4] . Simion et al proposed total thyroidectomy with ipsilateral modified neck dissection followed by radioactive iodine therapy [10] . Agosto-Vargas et al reported a case treated with total thyroidectomy followed by radiation therapy [4] .…”

Section: Discussionmentioning

confidence: 99%

Lateral neck ectopic thyroid carcinoma: Rare location for ectopic malignancy

Khadija

Oukessou

Rouadi

et al. 2021

International Journal of Surgery Case Reports

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Lateral neck ectopic thyroid tissue remains a rare entity that can be affected by any lesion involving the gland. The origin of lateral neck ectopic thyroid carcinomas still debated between a metastatic disease secondary to thyroid primary tumor and primary malignancy on the ectopic tissue. Anyway, it should indicate an exploration of the gland. We report the case of a 36 years old female with one year history of hyperthyroidism who was admitted for multinodular grade II goiter with a firm mass in the left level II of the lateral neck. The thyroid scintigraphy demonstrated multiple functioning nodules corresponding to toxic multinodular goiter; in addition to two cold hypofunctional nodules. The cervical ultrasound showed a voluminous multinodular goiter classified as EU TIRADS 5. The surgical procedure exposed a multinodular mass, lateral to the internal jugular vein, with the appearance and structure of the thyroid gland and no connection to it. The thyroid gland was exposed next through a collar incision. Each mass was dissected and removed individually. The histopathology examination of the thyroid gland found papillary carcinoma extracapsular extension. The pathology results of the other mass reported multiple colloid nodules with cystic component, papillary in appearance, with the same cancer proliferation, compatible with ectopic thyroid tissue with papillary carcinoma. No lymph node tissue was found. The patient was sent for complementary RAItherapy. We report a rare case of lateral neck ectopic thyroid papillary carcinoma that supplements and supports the lacking literature data concerning the management of this rare entity.

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Cervical lymphadenopathy: metastasis of papillary carcinoma or ectopic thyroid tissue?

Cited by 7 publications

References 5 publications

Ectopic Papillary Thyroid Carcinoma Mimicking Esophageal Cancer in FDG PET

Ectopic Papillary Thyroid Carcinoma Mimicking Esophageal Cancer in FDG PET

An unprecedented occurrence of incidental tonsillar ectopic primary Papillary Thyroid Carcinoma in an adult female: A case report

Lateral neck ectopic thyroid carcinoma: Rare location for ectopic malignancy

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