Cervical necrotizing fasciitis of odontogenic origin: A case report and review of 12 cases

Human Immunodeficiency Virus Infection Associated with Necrotizing Fasciitis: A Cohort Study of Texas Population, 2001-2010

“…The site of infection was described inconsistently in case reports of NF in HIV-infected patients. Two case reports indicated NF involving limbs [5,13], while cervical infection was described in 3 patients [7,10,11], and breast involvement in one [14]. While the small number of patients precludes meaningful analysis, the available data from these cases suggest involvement of uncommon body sites in patients with HIV-associated NF.…”

“…Chronic comorbidities were inconsistently described in reported cases HIV-associated NF though, when described, most affected patients had no non-HIV chronic illness [10,[12][13][14] or only a single one [7,11]. The reported chronic comorbidities included hypertension [7] and non-Hodgkin's lymphoma [11], with the later possibly a sequela of AIDS in the affected patient. Obesity was reported in 2.7% of our patients, markedly lower than in population studies of NF in the general population [2,24], possibly reflecting direct impact of HIV infection and its sequelae.…”

“…However, diabetes was reported only in about 1 in 7 HIV-associated NF hospitalizations, as compared to about 1 in 2 in the general population with NF [2]. Chronic comorbidities were inconsistently described in reported cases HIV-associated NF though, when described, most affected patients had no non-HIV chronic illness [10,[12][13][14] or only a single one [7,11]. The reported chronic comorbidities included hypertension [7] and non-Hodgkin's lymphoma [11], with the later possibly a sequela of AIDS in the affected patient.…”

“…Obesity was reported in 2.7% of our patients, markedly lower than in population studies of NF in the general population [2,24], possibly reflecting direct impact of HIV infection and its sequelae. Previous case reports on HIV-associated NF provided limited data on general physical exam, with only one describing an obese patient [7].…”

“…However, occurrence of HIV as an underlying illness among NF patients has not been examined at a population level, with only few case reports of HIV-associated NF described to date [5][6][7][8][9][10][11][12][13][14]. While the risk of HIV-associated NF may exceed that of the general population, there are sparse data on the epidemiology of NF in these patients.…”