Cervical osteomyelitis. Infection due to Staphylococcus epidermidis in hemodialysis patients

Parker, M

doi:10.1001/jama.240.1.50

Cited by 15 publications

(10 citation statements)

References 3 publications

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“…Coagulase-negative staphylococci cause not only infections of prosthetic devices (12,13) but also postoperative wound infections (4), peritonitis related to chronic peritoneal dialysis (8), and vascular and bone infections associated with hemodialysis (2,20). For over 15 years it has been known that coagulase-negative staphylococci are more resistant to antibiotics than their coagulase-positive counterparts (14).…”

mentioning

confidence: 99%

Activity of cephalosporins against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci: minimal effect of beta-lactamase

John¹,

McNeill²

1980

Antimicrob Agents Chemother

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Eight cephalosporins were tested for their activity against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci and for their resistance to ,B-lactamase from methicillin-resistant, coagulase-negative staphylococci. Susceptibility testing by the agar plate method was evaluated for the effect of inoculum size and duration of incubation. Methicillin-susceptible, coagulase-negative staphylococci were highly susceptible to the cephalosporins, with cephapirin and cephalothin showing the greatest activity, followed by cefazolin and cefamandole. Methicillin-resistant, coagulase-negative staphylococci displayed nearly total cross-resistance to the cephalosporins. Resistance increased with increasing inoculum size. fB-Lactamases produced by methicillin-resistant, coagulase-negative staphylococci had a minimal hydrolytic effect on cephalothin, cephapirin, cefazolin, and cefamandole and no measurable effect on cefoxitin. There was no correlation between the anti-staphylococcal activity and resistance to ,8-lactamases.Coagulase-negative staphylococci cause not only infections of prosthetic devices (12, 13) but also postoperative wound infections (4), peritonitis related to chronic peritoneal dialysis (8)

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mentioning

confidence: 99%

Activity of cephalosporins against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci: minimal effect of beta-lactamase

John¹,

McNeill²

1980

Antimicrob Agents Chemother

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“…10 Other studies have identified similar findings with CNS as the cause of hematogenous VO in 15% to 16% of the cases. 3,4,7 In these cases, indwelling intravascular devices were removed and appropriate antibiotics instituted with resultant clinical improvement without the need for surgical debridement. For example, in an 18-year review of 57 cases of pediatric vertebral osteomyelitis at one institution, only one case was caused by S epidermidis.…”

Section: Discussionmentioning

confidence: 99%

Hematogenous Coagulase-Negative Staphylococcal Vertebral Osteomyelitis

Riddell¹,

Quint²,

Kazanjian³

2012

Infectious Diseases in Clinical Practice

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“…Vascular access infections can lead to sepsis, endocarditis, and metastatic infectious foci, and account for up to 10% of the deaths in HD patients . Vertebral osteomyelitis and spondylodiscitis are two of the severe metastatic infectious foci in vascular access‐related bacteremia . Back pain is a cardinal symptom in patients with vascular access‐related bacteremia and vertebral osteomyelitis .…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis catheter infection with unusual presentation and grave outcome

Gabaldon

Sun

et al. 2011

Hemodialysis International

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Bacteremia from central venous catheter (CVC) infection causes morbidity and mortality in patients on hemodialysis (HD). Diagnosis of the infection can be difficult and may require special imaging. A 70-year-old man with diabetic nephropathy was on HD for 11 months through a permanent CVC. Because of symptomatic osteoporosis, he had kyphoplasty in three lumbar vertebrae (L2, L3, L4) 6 months after starting HD. Severe back pain persisted after kyphoplasty. Throughout the HD period, the exit site of the CVC had a clean appearance, there was no fever, and blood leukocyte counts were normal. During the 11th month of HD, he complained of subjective fever at home. Blood count revealed normal leukocyte count with neutrophilic predominance and blood cultures grew methicillin-resistant Staphylococcus aureus (MRSA). Echocardiogram revealed no heart valve vegetations, but irregular thickening of the CVC wall. Fluorodeoxyglucose positron-emission tomography-computed tomography (FDG-PET-CT) revealed severe inflammation of the CVC wall and a picture consistent with osteomyelitis and severe destruction of the body of the 11th thoracic vertebra. He was treated with intravenous vancomycin and removal of the CVC, the wall of which was grossly inflamed and grew in culture MRSA. Three weeks later, he discontinued HD because of persistent severe back pain. CVC infection with bacteremia and remote infectious foci having grave sequelae can develop in HD patients with paucity of clinical manifestations. FDG-PET-CT is a useful imaging tool in establishing the presence and extent of both the CVC infection and remote metastatic infectious foci.

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Cervical osteomyelitis. Infection due to Staphylococcus epidermidis in hemodialysis patients

Cited by 15 publications

References 3 publications

Activity of cephalosporins against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci: minimal effect of beta-lactamase

Activity of cephalosporins against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci: minimal effect of beta-lactamase

Hematogenous Coagulase-Negative Staphylococcal Vertebral Osteomyelitis

Hemodialysis catheter infection with unusual presentation and grave outcome

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