Cervical Pathology in Cytology-Negative/HPV-Positive Women: Results from Lampang Cancer Hospital, Thailand

Paengchit, Kannika; Kietpeerakool, Chumnan; Wangchai, Warunee; Pouraeng, Saifon; Lalitwongsa, Somkiet

doi:10.7314/apjcp.2014.15.18.7951

Cited by 6 publications

(11 citation statements)

References 16 publications

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“…However, when compared to the other studies in Thailand, the prevalence was a little bit lower from that of 11% in Lampang province locating in northern Thailand (Paengchit et al, 2014) and was much higher than that of 2.4% in Khon Kaen province locating in the northeastern region of Thailand (Supho et al, 2014). The Northeastern study (Supho et al, 2014) did not mention the type of HPV test and did not perform a random biopsy in patients who had negative colposcopy findings unlike the northern study and the present study.…”

Section: Discussionmentioning

confidence: 53%

“…The Northeastern study (Supho et al, 2014) did not mention the type of HPV test and did not perform a random biopsy in patients who had negative colposcopy findings unlike the northern study and the present study. The northern study (Paengchit et al, 2014) which used an EIA kit HPV GP HR (Diassay Rijswijk, The Netherlands) for HPV testing and carried out random biopsy in women with normal colposcopic findings. The random biopsy performed in women who had a negative finding from colposcopy in the northern study and the present study seemed to increase the detection of significant lesions.…”

Section: Discussionmentioning

confidence: 99%

“…In Thailand, 2 publications from the north and northeastern regions of Thailand reported a different prevalence of HSIL in HPVpositive and cytology negative women at 11% and 2.4%, respectively. Both studies utilized different methods for HPV testing (Paengchit et al, 2014;Supho et al, 2014). Due to the variation of prevalence of significant lesions in Thailand, we conducted a retrospective study to evaluate the prevalence of significant lesions in women who tested HPV positive only from co-testing cervical cancer screening at our institute.…”

Section: Introductionmentioning

confidence: 99%

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Histologic Outcomes in HPV-Positive and Cervical Cytology-Negative Women - Screening Results in Northern Thailand

Vijakururote

Suprasert²,

Srisomboon³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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The objective of this study was to determine the prevalence of significant lesions defined as high grade squamous intraepithelial lesions (HSIL), adenocarcinoma in situ (AIS) and invasive carcinoma in women who had HPV-positive and cytology negative co-testing screening results. This retrospective study was conducted in Chiang Mai University Hospital between May, 2013 and August, 2014. Hybrid capture 2 (HC2) was used for HPV testing and conventional Pap smears for cytologic screening. A repeat liquid-based cytology (LBC) was performed in women with such co-testing results followed by colposcopy. Random biopsy was performed in cases of normal colposcopic findings. Further investigations were carried out according to the biopsy or the repeat LBC results. During the study period, 273 women met the criteria and participated in the study. The mean age of these women was 46.4 years with 30% of them reporting more than one partner. The median interval time to colposcopy was 165 days. About 40% showed an abnormality in the repeat cytology. Significant cervical lesions were found in 20 (7.3%) women, including 2 invasive cancers. Of interest was that only 2 of 20 significant lesions were diagnosed by colposcopic examination while the remainder were initially detected by cervical biopsy and abnormal repeat cytology. In conclusion, the prevalence of significant cervical lesions in HPV positive and cytology negative women in Northern Thailand was 7.3%. Further diagnostic work up with repeat cytology follow by colposcopy is recommended. Random biopsy should be performed even when the colposcopic findings are normal.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histologic Outcomes in HPV-Positive and Cervical Cytology-Negative Women - Screening Results in Northern Thailand

Vijakururote

Suprasert²,

Srisomboon³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…HPV testing has been shown to increase the sensitivity of the detection of intraepithelial lesions in 45% more cases compared with cytological screening. [7][8][9][10][11][12]15 The detection of hr-HPV cervical infections is important for determining the prevalence of HPV in specific populations, thereby aiding in the planning of appropriate strategies for CC prevention programs. [16][17][18] A new HPV DNA test approved by the US Food and Drug Administration (careHPV; Qiagen, Gaithersburg, MD) has been developed for use in low-income regions.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6] Molecular tests for HPV DNA or RNA have been designed to identify hr-HPV in cervical samples; these tests are both reliable and reproducible and can be implemented more easily than cytological analysis. [7][8][9][10][11][12][13][14] New guidelines for CC screening recommend the combined use of HPV testing and cytology over the use of cytology alone. HPV testing has been shown to increase the sensitivity of the detection of intraepithelial lesions in 45% more cases compared with cytological screening.…”

Section: Introductionmentioning

confidence: 99%

Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?

Lorenzi

Fregnani

Possati-Resende

et al. 2016

Cancer Cytopathology

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<p>Sexual behavior and infection with cervical human papillomavirus types 16 and 18</p>

Itarat¹,

Kietpeerakool²,

Jampathong³

et al. 2019

IJWH

Self Cite

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ObjectiveThis study assessed whether sexual behavior, including engaging in early sexual intercourse and having had multiple sexual partners, can predict the risk of infection with cervical human papillomavirus (HPV) types 16 and 18.MethodsRecords were reviewed of women who underwent cervical cancer screening and were found to be infected with high-risk HPV. The genotypes of high-risk HPV were categorized as HPV 16, HPV 18, and other than 16 or 18. Early sexual intercourse was defined as first sexual intercourse at the age of 19 years or younger. Multiple sexual partners was defined as having more than three lifetime sexual partners. Associations between sexual behavior and HPV 16/18 infection were presented as odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOf the 349 women included in the study, 72 (20.6%) and 30 (8.6%) were infected by HPV 16 and 18, respectively. Eighty-two women (26.0%) reported having engaged in early sexual intercourse, and 33 (10.4%) reported having had multiple sexual partners. After adjustment for age, parity, and smoking habits, we found that women who had engaged in early sexual intercourse tended to have a higher risk of HPV 16 (OR 1.74; 95% CI 0.93–3.29), and those who had had multiple sexual partners were found to be at a significantly higher risk for HPV 18 (OR 4.58; 95% CI 1.44–14.58).ConclusionSexual behavior was associated with an increased risk of HPV 16/18 infection. Engaging in early sexual intercourse increased the risk of HPV 16 infection, and having had multiple sexual partners increased that of HPV 18.

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Cervical Pathology in Cytology-Negative/HPV-Positive Women: Results from Lampang Cancer Hospital, Thailand

Cited by 6 publications

References 16 publications

Histologic Outcomes in HPV-Positive and Cervical Cytology-Negative Women - Screening Results in Northern Thailand

Histologic Outcomes in HPV-Positive and Cervical Cytology-Negative Women - Screening Results in Northern Thailand

Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?

<p>Sexual behavior and infection with cervical human papillomavirus types 16 and 18</p>

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