Cervical ripening with mifepristone before labor induction: a randomized study

Abstract

Mifepristone proved effective for cervical ripening and reduced the time to delivery compared with placebo, but it did not improve the rate of cesarean. Our study did not include enough pregnancies to reach conclusions about fetal or neonatal safety.

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

“…These observations are in accordance with the existing literature where a variable success rate of labor onset at 66-93 % has been observed in pregnant women [8][9][10][11][12][13][14][15]. Also, the effect of cervical ripening after use of mifepristone has been variable ranging from no statistically difference to statistically significant improvement (60-80 % of all cases) [16][17][18][19][20]. However, all these studies except one [11] were conducted in women without previous CS.…”

Mifepristone and misoprostol in the induction of labor at term

“…The role of mifepristone in inducing labor when the fetus is viable is being evaluated [6][7][8][9][10]. Mifepristone in doses of 200 to 400 mg has been shown to improve cervical ripening and rates of bspontaneousQ labor, with no apparent maternal or neonatal adverse effects.…”

Different methods for the induction of labour in outpatient settings

“…Sixteen studies used either external or pharmacy randomisation services, or identical coded drug packs from pharmacy to conceal group allocation Buttino 1990;Giacalone 1998;Habib 2008;Kipikasa 2005;Lelaidier 1994;Lien 1998;McKenna 1999;McKenna 2004;O'Brien 1995;Oboro 2005;Sawai 1994;Stitely 2000). Four trials used sealed, opaque, sequentially numbered envelopes to conceal allocation (Bullarbo 2007;Harper 2006;Larmon 2002;; envelopes were also used in the Meyer 2005 and Stenlund 1999 trials, although in the former it was not stated that they were sealed, and in the latter that they were opaque.…”

“…We included five studies in this comparison (Elliott 1998;Giacalone 1998;Lelaidier 1994;Stenlund 1999). Women in the mifepristone group were less likely to require further medication to induce labour compared with controls ((random-effects) RR 0.59, 95% CI 0.37 to 0.95).…”

“…Mifepristone versus placebo (five studies) (Elliott 1998;Giacalone 1998;Lelaidier 1994;Stenlund 1999).…”