Cervical Spinal Cord Injury Shows Markedly Lower than Predicted Mortality (>72 Hours After Multiple Trauma) From Sepsis and Multiple Organ Failure

Abstract

Cervical SCI leads to an increased rate of sepsis and MOF but appears to be favorable with respect to outcome of sepsis and MOF following multiple trauma. Further research should focus on the pathomechanisms and the possible arising therapeutic options.

Potential clinical impact of metagenomic next-generation sequencing of plasma for cervical spine injury with sepsis in intensive care unit: A retrospective study

“…CSI accounts for a majority of patients in ICU with a high mortality ( Ahuja et al., 2017 ; Ghajarzadeh et al., 2019 ). There is increasing evidence that sepsis remains to be one of the major causes of death in patients with CSI in ICU ( Cao et al., 2019 ; Buzzell et al., 2020 ; Kamp et al., 2020 ). Thus, timely diagnosis for sepsis and therapeutic actions targeting sepsis is crucial to improving patient prognosis.…”

“…The incidence of CSI for the general population is 0.13 per 1,000 ( Wu et al., 2012 ), and mortality in patients with CSI has been reported to be three times more than that in age-matched healthy subjects ( Ghajarzadeh et al., 2019 ). CSI leads to an increased rate of sepsis, which remains to be one of the main causes of death following CSI ( Cao et al., 2019 ; Buzzell et al., 2020 ; Kamp et al., 2020 ). Thus, it is necessary to timely diagnose sepsis and deliver the therapeutic actions targeting sepsis to the patients with CSI.…”