Cervical Spine MR Imaging Findings of Patients with Hirayama Disease in North America: A Multisite Study

Lehman, Vance T.; Luetmer, Patrick H.; Sorenson, Eric J.; Carter, R. E.; Gupta, Vipin Kumar; Fletcher, Geoffrey P.; Hu, L. S.; Kotsenas, Amy L.

doi:10.3174/ajnr.a3277

Cited by 60 publications

(59 citation statements)

References 15 publications

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“…Nevertheless this sign is not always present in HD patients. Zhou et al and Lheman et al reported a prevalence respectively of 71% and 76% (10,35). Interestingly, Lai et al (36) demonstrated the presence of anterior shifting of posterior dural sac in 46% of healthy subjects, of a lesser degree compared to patients group and without evidence of cord compression.…”

Section: Discussionmentioning

confidence: 97%

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Hirayama’s disease: an Italian single center experience and review of the literature

Vitale¹,

Caranci²,

Pisciotta³

et al. 2016

Quant. Imaging Med. Surg.

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HD is a rare entity and a self-limited condition, but it has to be early differentiated from other diseases that may determine myelopathy and amyotrophy to establish a correct therapy and limit arm impairment. MRI is very important to confirm the clinical suspect of HD and a standardized MRI protocol using axial and sagittal images in both neutral and flexing position is needed, in order to diagnose and follow up affected patients.

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Section: Discussionmentioning

confidence: 97%

“…CF has a various prevalence in different case series. Yin et al, Hassan et al and Raval et al (6,27,31) reported a 100% of prevalence while Lehman et al (10) and Yang et al (32) found it respectively in 48% and 43%. Finsterer et al (9) executed MRI studies in the neutral position and reported asymmetric CF only in one patient of seven.…”

Section: Discussionmentioning

confidence: 97%

Hirayama’s disease: an Italian single center experience and review of the literature

Vitale¹,

Caranci²,

Pisciotta³

et al. 2016

Quant. Imaging Med. Surg.

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“…Insufficient growth of the dura relative to the spine during adolescence causes forward displacement of the dura in flexed positions of the cervical spine. 6 The subsequent compression of the spinal cord against the vertebral bodies compromises microcirculation. 7 In the slowly progressing Hirayama syndrome, damage to the cord parenchyma is confined to the anterior horn of the spinal cord gray matter with consecutive flaccid paresis in the upper extremities.…”

Section: Discussionmentioning

confidence: 99%

Tetraparesis as clinical correlate of subacute cervical flexion myelopathy

Fehre

Weber

Hensel

et al. 2016

The Journal of Spinal Cord Medicine

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Context:We report the case of a 20-year-old woman who underwent tracheal resection with postoperative chinto-chest suture for 10 days, presenting with severe tetraparesis at our institution. Similar cases have been reported previously, however, not yet in the pathophysiological context of chronic cervical flexion myelopathy (Hirayama syndrome). Findings: Extensive myelopathy at cervical level is the consequence of the fixed cervical spine position due to chin-to-chest suture. Predominantly affected young individuals (age range from 20-25 years) without evidence of degenerated spine disease suggest a similar mechanism as described in Hirayama syndromedisplacement of the dura with consecutive compression of the spinal cord vasculature. Conclusions: Subacute flexion myelopathy represents a serious complication of operative/postoperative fixed cervical spine positions, warranting particular attention by respective surgeons.

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“…The disappearance of physiological lordosis of the cervical vertebrae was reported by Hashimoto et al 9 in 11 of 15 patients, Sonwalkar et al 10 in 6 of 8 patients, Raval et al 11 in 9 of 9 patients and Hassan et al 12 in 10 of 11 patients. Abnormal cervical curvature is an important finding on the cervical MRI for the diagnosis of Hirayama disease 13. Masaki et al 14 performed posterior fixation in patients with cervical kyphosis, which resulted in the relief of symptoms.…”

Section: Discussionmentioning

confidence: 99%

A 20-year-old female with Hirayama disease complicated with dysplasia of the cervical vertebrae and degeneration of intervertebral discs

et al. 2012

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A 20-year-old female patient was presented with a 1-year history of progressive weakness of the left hand. Examination on admission showed atrophy of the muscles of the left forearm, cold paralysis and minipolymyoclonus. MR images of the cervical cord showed anterior transfer of the cervical cord on anterior flexion and cervical cord compression at the site of cervical kyphosis, confirming the diagnosis of Hirayama disease. Many features of the present case are unusual: the patient is a female (who are rarely afflicted by this disease), with cervical kyphosis and a history of exercise involving cervical vertebral loading, suggesting a potential involvement of the latter two factors in the disease onset. The findings suggest that cervical vertebral dysplasia and intervertebral disc degeneration may influence cervical kyphosis, and be involved in the onset of Hirayama disease. BACKGROUND

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Cervical Spine MR Imaging Findings of Patients with Hirayama Disease in North America: A Multisite Study

Cited by 60 publications

References 15 publications

Hirayama’s disease: an Italian single center experience and review of the literature

Hirayama’s disease: an Italian single center experience and review of the literature

Tetraparesis as clinical correlate of subacute cervical flexion myelopathy

A 20-year-old female with Hirayama disease complicated with dysplasia of the cervical vertebrae and degeneration of intervertebral discs

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