Cervical spondylitic myeloradiculopathy due to chronic brucellosis in a Ugandan teenager

Kyebambe, Peterson S; Kasyaba, R; Nkakyekorera, S

doi:10.4314/ahs.v12i3.25

Cited by 1 publication

(4 citation statements)

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“…Twenty-eight patients (28%) received 3 antibiotic regimens, and 3 patients (3%) received 4 antibiotic regimens. All patients had treatment courses planned for 6 weeks, except 1 who was treated for 20 weeks [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…Rifampin, ceftriaxone, and ofloxacin may be effective [ 16 ]. The addition of a third agent is recommended in some combinations and in neurologic disease [ 12 , 16 ]. In this cohort, 97 (96%) met the national treatment standard, typically doxycycline combined with an aminoglycoside.…”

Section: Discussionmentioning

confidence: 99%

“…Duration of antimicrobial therapy was typically 6 weeks, but it was extended if there was an incomplete clinical response. The longest duration of treatment noted at this hospital was 20 weeks [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Titers may lead to false positives in a region with high background endemicity for brucellosis and coexisting comorbid illnesses. False negatives may be seen in patients who may have acute brucellosis but have not yet mounted a significant antibody titer at the time of phlebotomy, those with chronic brucellosis, immunologic impairment, or those with the prozone phenomenon [ 12 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Human Brucellosis in Rural Uganda: Clinical Manifestations, Diagnosis, and Comorbidities at Kabale Regional Referral Hospital, Kabale, Uganda

Dieckhaus

Kyebambe

2017

Open Forum Infectious Diseases

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BackgroundBrucellosis is a zoonotic infection transmitted to humans through direct contact with infected animals, their products, or excreta such as urine or dung. Brucellosis is associated with significant morbidity in Southwestern Uganda, where cattle and goat rearing are a major economic industry. As in many settings in sub-Saharan Africa, diagnosis and management of brucellosis remain a challenge due to the presence of comorbidities and limitations in resources for diagnostic testing and therapy.MethodsA chart review was conducted to characterize the clinical manifestations, diagnosis, comorbidities, and management of 101 patients treated for brucellosis at the Kabale Regional Referral Hospital from September 2002 to May 2010.ResultsPatients presented with substantial comorbidities. The most common manifestation of illness was osteoarticular, but disease manifestations were quite varied. A high rate of focal illness in this cohort (77%) was observed.ConclusionsClinicians in this setting should be cognizant of the varied presentations, comorbidities, and treatment options for this disease.

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Section: Resultsmentioning

confidence: 99%