Cervical sympathetic chain schwannoma associated with parathyroid adenoma

Manzanedo-Romero, Israel; García-Muñoz-Najar, Alejandro; Acín-Gándara, Débora; Carrión-Álvarez, Lucía; Urbasos-Pascual, María; Pereira-Pérez, Fernando

doi:10.1016/j.circen.2015.10.007

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Clinical presentation is misleading, it is usually an asymptomatic slow-growing cervical mass. The diagnosis is based on radiological findings, especially CT scan and IMR [5].…”

Section: Introductionmentioning

confidence: 99%

A Report on a Case and Literature Review on Cervical Sympathetic Chain Schwannoma that Mimics a Paraganglioma

Lakhdar,

El Khalifa,

Mohamed Amine

et al. 2024

CLINICMED

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Background: Cervical sympatric schwannoma is a rare benign tumor originating from de Schwan cells. Its clinical presentation is misleading and it can remain asymptomatic for a long time. Mostly, it appears as slow slow-growing cervical mass and may be a differential diagnosis with other neck masses such as paragangliomas. We discuss a case of Cervical sympatric schwannoma and go over its radiological, surgical, and surgical characteristics. Case Presentation: With no prior medical history, a 61-year-old lady appeared with a right cervical mass that had been present for over two years but had lately grown in size without causing dysphagia, dysphonia, or dyspnea. Clinical examination found a firm, slightly pulsatile, non-painful latero-cervical mass measuring 2 × 3 cm. Without other abnormalities on examination of the upper aerodigestive tract or thyroid gland and no neurological deficit. Cervical Ultrasound showed an oval tissular mass with regular contours in close contact with the right common carotid artery. Computed Tomography showed a right superior jugulocarotid mass located behind the vascular axis of the neck with early central vascularization. On magnetic resonance imaging (MRI), this mass was well limited, hypointense on T1 and hyper-intense on T2 with intense contrast enhancement, corresponding to a paraganglioma or schwannoma. A full blood work came back negative. Our patient underwent a complete surgical excision of the tumour which originated in the deep branches of the cervical plexus. Following surgery, the patient had Horner’s syndrome, histopathology confirmed the diagnosis of schwannoma. Conclusions: It is still challenging to differentiate between cervical sympathetic chain schwannoma and paraganglioma clinically and radiological. In the case of the schwannoma surgical approaches must be as conservative as possible to avoid damages of the origin nerve and the patient must be aware of the possibility of Horner syndrome.

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“…Clinical presentation is misleading, it is usually an asymptomatic slow-growing cervical mass. The diagnosis is based on radiological findings, especially CT scan and IMR [5].…”

Section: Introductionmentioning

confidence: 99%

A Report on a Case and Literature Review on Cervical Sympathetic Chain Schwannoma that Mimics a Paraganglioma

Lakhdar,

El Khalifa,

Mohamed Amine

et al. 2024

CLINICMED

View full text Add to dashboard Cite

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Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer

Afreen

Weinstein

Simonds

et al. 2022

Journal of the Endocrine Society

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We present the case of a 53-year-old African-American male with recurrent primary hyperparathyroidism (PHPT), multi-focal benign granular cell tumor (GCT) and metastatic colon adenocarcinoma. PHPT was diagnosed on routine blood testing [ionized calcium 1.66 (1.12-1.32) mmol/L, PTH 110pg/mL, Vitamin D-25-OH-D: 18ng/mL, PTHrP: undetectable]. Medical history was notable for two reoccurrences of PHPT with persistent disease after most recent parathyroidectomy. Lymph node (LN) dissection during this last surgery showed a 2-mm focus of poorly differentiated adenocarcinoma in 1/5 LNs. Additionally, patient had a history of multi-focal GCTs diagnosed at age two. On exam, there were no Lisch nodules, axillary, or inguinal freckling, neurofibromas or café-au-lait macules but a prominent abdominal wall nodule was noted. En bloc resection of a tumor in the tracheoesophageal groove, identified by sestamibi scan and excision of 4.5-cm abdominal wall nodule showed both masses having histology consistent with GCT. Serum calcium and PTH did not decrease indicating another unsuccessful surgery. Genetic testing was negative for germline variants in PHPT-associated genes, APC or genes of RAS-MAPK signaling pathway. The LN finding of metastatic adenocarcinoma prompted an endoscopy and trans-bronchial biopsy leading to the diagnosis of widely metastatic colonic adenocarcinoma, eventually resulting in his death a year later. Source of patient’s persistent PHPT remained unidentified. This is the first case with co-association of recurrent PHPT, multi-focal GCT and colon cancer. Whether the disparate tumors in this patient share common driver(s) remains unknown. Prospective surveillance of patients for similar associations may provide clues for a novel syndromic form of PHPT.

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Cervical sympathetic chain schwannoma associated with parathyroid adenoma

Cited by 2 publications

References 15 publications

A Report on a Case and Literature Review on Cervical Sympathetic Chain Schwannoma that Mimics a Paraganglioma

A Report on a Case and Literature Review on Cervical Sympathetic Chain Schwannoma that Mimics a Paraganglioma

Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer

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