Cervicovaginal fetal fibronectin as a marker for preterm delivery: A meta-analysis

Leitich, Harald; Egarter, Christian; Kaider, Alexandra; Hohlagschwandtner, Maria; Berghammer, Peter; Husslein, Peter

doi:10.1016/s0002-9378(99)70612-5

Cited by 136 publications

(89 citation statements)

References 33 publications

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“…Recent advances in prenatal health care have markers that facilitate more accurate prediction of preterm birth. The use of biological markers to enhance clinical accuracy in predicting preterm birth has been recently proposed [2][3][4][5] . These tests have high capacity to identify the patients with high risk.…”

Section: Discussionmentioning

confidence: 99%

“…Accurate markers to determine whether a pregnant woman is at high risk for premature delivery would potentially allow improved surveillance and more timely intervention to improve the outcome [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

“…Many tests have been reported to predict SPB such as cervicovaginal fetal fibronectin and cervical alpha fetoprotein [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

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Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Sak

Sak²,

Gül³

2010

J Clin Exp Invest

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ÖZETAmaç: Preterm doğum erken belirteci olarak serviko-vajinal sekresyonlardaki koriyonik gonadotropin'in rolünü araştırmak.Yöntemler: Bir önceki doğumu erken doğum veya ikinci trimester düşük öyküsü risk faktörü olan, 25-36 gebelik haftasına sahip 55 gebe çalışmaya alındı. Hastaların tü-münde servikovajinal sekresyonlardaki beta-insan koriyonik gonadotropin (β-hCG) düzeyleri radioimmunassay yöntemiyle ticari bir kit kullanılarak ölçüldü. Bulgular:Gebelerden 25'i preterm, 30'u term doğum yaptı. Term ve preterm doğum yapana gebe grupları arasında yaş, gebelik sayısı ve parite açısından farklılık saptanmadı (P>0.05). Preterm doğum grubunda yenidoğan APGAR skorları ve bebeklerin antropometrik ölçümleri term doğum grubundan anlamlı düşük bulundu (P<0.05). Serviko-vaginal β-hCG düzeyleri; preterm grubunda, term doğum grubuna göre anlamlı yüksek bulundu (sırasıyla 94.7±37.7 mIU/ml ve 35.5±14.8 mIU/ml, P<0.001). Beta-hCG için, 75 mIU/ml cut-off değeri olarak alındığında; duyarlılığı %76, özgüllüğü %91.6, pozitif prediktif değeri %95 ve negatif prediktif değeri %79.9 olarak bulundu. Sonuç: Preterm doğum açısından yüksek riskli hastalarda servikovajinal sekresyonlardaki β-hCG konsantrasyonu iyi bir biyokimyasal belirteç olabilir. Servikovajinal sıvılardaki β-hCG düzeyine dayanarak preterm doğum geliştireceği öngörülen hastalarda daha yakın takip ile komplikasyonlar azaltılabilir. Klin Den Ar Derg 2010; 1(1): [16][17][18][19][20] Anahtar kelimeler: Preterm doğum, beta-hCG, prediktif değer, serviko-vajinal sekresyonlar ABSTRACT Objectives: To investigate beta-human corionic gonadotropin (β-hCG) levels in cervicovaginal secretions as an early marker for preterm delivery. Methods:The study included 55 patients at 25-36 of gestational weeks with preterm delivery risk factors including a history of preterm labor in a previous pregnancy or history of second trimester abortion. Beta-human chorionic gonadotropin (β-hCG) levels of cervicovaginal secretions were measured in all patients by the radioimmunoassay method using a commercial kit.Results: Preterm delivery was observed in 25 patients and 30 patients gave term delivery. No significant differences were found between preterm and term delivery groups in age, gravidity and parity (P>0.05). APGAR scores and anthropometric measurements of newborns were significantly lower in preterm delivery group (P<0.001). Preterm delivery group had significantly higher cervicovaginal β-hCG levels compared with normal controls (94.7±37.7 vs. 35.5±14.8 mIU/ml, respectively, P<0.001). When 75 mIU/ml value of β-hCG level was taken as cut-off value; the sensitivity of the test was found as 76%, specifity 91.6%, positive predictive value 95.0% and negative predictive value as 79.9%. Conclusion:Concentrations of β-hCG in cervicovaginal secretions may be a useful early biochemical marker to detect preterm. Based on β-hCG levels in cervicovaginal secretions a closer follow-up may decrease some complications of preterm delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Sak

Sak²,

Gül³

2010

J Clin Exp Invest

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“…In contrast with the previous four systematic reviews [12][13][14][15] we identified 64 studies (at least twice as many studies as the largest previous review 14 ) because we did not limit our search to a single database 13 15 nor did we apply language restrictions. 13 Because meta-analysis of studies that examine test accuracy are fraught with difficulty owing to poor methodological quality of the primary studies, we scrutinised the selected studies for their quality, an assessment undertaken in only one previous review.…”

Section: Quality Of Our Reviewmentioning

confidence: 99%

“…In addition, existing systematic reviews have been restricted to a few databases, [12][13][14][15] their study selection has often been limited by language, 12 13 15 and often they have not assessed study quality. [12][13][14] These factors are known to introduce potential for bias. 16 We conducted a comprehensive and rigorous systematic review to obtain reliable estimates of accuracy.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Honest

Bachmann²,

Kleijnen³

et al. 2003

Journal of Obstetrics and Gynaecology

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Objective To determine the accuracy with which a cervicovaginal fetal fibronectin test predicts spontaneous preterm birth in women with or without symptoms of preterm labour. Design Systematic quantitative review of studies of test accuracy. Data sources Medline, Embase, PASCAL, Biosis, Cochrane Library, Medion, National Research Register, SCISEARCH, conference papers, manual searching of bibliographies of known primary and review articles, and contact with experts and manufacturer. Study selection Two reviewers independently selected and extracted data on study characteristics, quality, and accuracy. Data extraction Accuracy data were used to form 2×2 contingency tables with spontaneous preterm birth before 34 and 37 weeks' gestation and birth within 7-10 days of testing (for symptomatic pregnant women) as reference standards. Data were pooled to produce summary receiver operating characteristic curves and summary likelihood ratios for positive and negative test results. Data synthesis 64 primary articles were identified, consisting of 28 studies in asymptomatic women and 40 in symptomatic women, with a total of 26 876 women. Among asymptomatic women the best summary likelihood ratio for positive results was 4.01 (95% confidence interval 2.93 to 5.49) for predicting birth before 34 weeks' gestation, with corresponding summary likelihood ratio for negative results of 0.78 (0.72 to 0.84). Among symptomatic women the best summary likelihood ratio for positive results was 5.42 (4.36 to 6.74) for predicting birth within 7-10 days of testing, with corresponding ratio for negative results of 0.25 (0.20 to 0.31). Conclusion Cervicovaginal fetal fibronectin test is most accurate in predicting spontaneous preterm birth within 7-10 days of testing among women with symptoms of threatened preterm birth before advanced cervical dilatation.

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Fetal fibronectin testing for reducing the risk of preterm birth

Berghella

Hayes

Visintine

et al. 2007

Cochrane Database of Systematic Reviews

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Let us know how access to this document benefits you Recommended Citation Recommended Citation Berghella, Vincenzo and Saccone, Gabriele, "Fetal fibronectin testing for reducing the risk of preterm birth." (2019). Department of Obstetrics and Gynecology Faculty Papers. Paper 55. https://jdc.jefferson.edu/obgynfp/55 This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Department of Obstetrics and Gynecology Faculty Papers by an authorized administrator of the Jefferson Digital Commons.

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Cervicovaginal fetal fibronectin as a marker for preterm delivery: A meta-analysis

Cited by 136 publications

References 33 publications

Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Fetal fibronectin testing for reducing the risk of preterm birth

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