Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection

Dai, Wenkui; Du, Hui; Li, Shuai Cheng; Wu, Ruifang

doi:10.3389/fonc.2021.722639

Cited by 15 publications

(27 citation statements)

References 106 publications

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“…Six immune-related genes (chemokine receptor 7 (CCR7), CD3d molecule (CD3D), CD3e molecule (CD3E), and integrin subunit beta 2 (ITGB2), family with sequence similarity 133 member A (FAM133A), and tumor protein p53 (TP53)) identified as prognostic model to forecast the survival and response to immunotherapy to indicate immune status based on multi-omics data analyses [ 92 ]. Cervicovaginal microbiome plays a role in hrHPV susceptibility and clearance, and imbalanced cervicovaginal microbiome increases the risk of developing CC [ 93 , 94 ]. Multi-omics combination of cervical microbiota data with urine metabolomics allows enhanced understanding of community functions in the disease and interactions with host by investigating the association between the host microbiome and circulating metabolites.…”

Section: Resultsmentioning

confidence: 99%

Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review

et al. 2022

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As the fourth most diagnosed cancer, cervical cancer (CC) is one of the major causes of cancer-related mortality affecting females globally, particularly when diagnosed at advanced stage. Discoveries of CC biomarkers pave the road to precision medicine for better patient outcomes. High throughput omics technologies, characterized by big data production further accelerate the process. To date, various CC biomarkers have been discovered through the advancement in technologies. Despite, very few have successfully translated into clinical practice due to the paucity of validation through large scale clinical studies. While vast amounts of data are generated by the omics technologies, challenges arise in identifying the clinically relevant data for translational research as analyses of single-level omics approaches rarely provide causal relations. Integrative multi-omics approaches across different levels of cellular function enable better comprehension of the fundamental biology of CC by highlighting the interrelationships of the involved biomolecules and their function, aiding in identification of novel integrated biomarker profile for precision medicine. Establishment of a worldwide Early Detection Research Network (EDRN) system helps accelerating the pace of biomarker translation. To fill the research gap, we review the recent research progress on CC biomarker development from the application of high throughput omics technologies with sections covering genomics, transcriptomics, proteomics, and metabolomics.

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Section: Resultsmentioning

confidence: 99%

Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review

et al. 2022

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“…A growing number of studies demonstrated the association of CVM with HPV infection. However, HPV acquisition was mainly impacted by sex activities and thus possible for women with any CVM structure ( Bruni et al., 2010 ; Dai et al., 2021 ), suggestive of heterogeneous CVM for HPV-positive women ( Gao et al., 2013 ; Chao et al., 2019 ). In addition, CVM structure can be impacted by many factors such as hygiene habits, ethnicity and age.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, longitudinal studies indicated the vital impact of CVM on persistence of HPV infection ( Mitra et al., 2020 ; Usyk et al., 2020 ). Therefore, clinical outcomes of HPV infection may be determined by CVM, which can function as a major immune modulator via microbe- and host-microbe interactions ( Anahtar et al., 2015 ; Dai et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Cervicovaginal microbiota significantly changed for HPV-positive women with high-grade squamous intraepithelial lesion

Guo

Dai

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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Lower female genital tract is colonized by a variety of microbes (cervicovaginal microbiota, CVM) which associate with the risk of genital infection. This study characterized CVM for 149 Chinese women with different status of human papillomavirus (HPV) infection and squamous intraepithelial lesion (SIL): no HPV infection (HPV-), HPV infection without significant SIL (HPV+NoSIL), HPV infection with low-grade SIL (HPV+LSIL) and HPV infection with high-grade SIL (HPV+HSIL). Analysis results showed CVM has dramatically changed in HPV+HSIL group when compared to HPV+LSIL group, but it exhibited no significant differences between HPV- and HPV+NoSIL groups as well as between HPV+NoSIL and HPV+LSIL groups. In consistence, random forest analysis found more notable differences in HPV+HSIL vs HPV+LSIL comparison than in other comparisons. In addition, depletion of Lactobacillus in CVM was more to be frequently identified in SIL-positive women as compared to SIL-negative individuals. Our findings suggested that significant CVM differences occurred when SIL developed to HSIL which was caused by persistent HPV infection.

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“…Moreover, newer studies have also uncovered the beneficial effect of the cervicovaginal microbiome, precisely certain Lactobacillus spp., in inhibiting cellular cervical pathogenesis by producing bacteriocins, lactic acid, and hydrogen peroxide. Ongoing studies may soon further elucidate the underlying physiology of microbe- and host-microbe interactions with HPV infection ( 134 , 135 ).…”

Section: Treatment Of Persistent Hpv Infection and Cervical Cancer In...mentioning

confidence: 99%

Current Status of Human Papillomavirus Infection and Cervical Cancer in the Philippines

Lintao

Cando²,

Perias³

et al. 2022

Front. Med.

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Cervical cancer is estimated to cause 341,831 deaths each year, with 9 of 10 deaths occurring in developing countries. Over the past decade, there has been a significant increase in cervical cancer incidence among women in the Philippines. Persistent infection with high-risk human papillomavirus (HPV) is the well-established necessary cause of cervical cancer. Based on limited studies conducted in the Philippines, the prevalence of infection with any HPV genotype was 93.8% for cervical squamous cell carcinoma and 90.9% for cervical adenocarcinomas. HPV types 16 and 18 were the most common HPV genotypes among Filipino patients with cervical cancer. On the other hand, the incidence of HPV infection among Filipino women with normal cervices was 9.2%. The World Health Organization has launched a global agenda of eliminating HPV infection by 2030. One of its key milestones is to vaccinate 90% of girls with the HPV vaccine by 15 years. However, the HPV vaccination rate among Filipino women remains to be unsatisfactory. HPV vaccination has only been included in the Philippine Department of Health's community-based National Immunization Program in 2015. Despite these efforts, the Philippines currently ranks last on HPV program coverage among low-middle income countries, with coverage of only 23% of the target female population for the first dose and 5% for the final dose. The principal reason for the non-acceptance of HPV vaccines was the perceived high cost of vaccination. The low utilization of available cervical cancer screening tests such as Pap smear and visual inspection with acetic acid hampered the Philippines' control and prevention of HPV infection and cervical cancer. Among those diagnosed with cervical cancer in the Philippines, only an estimated 50% to 60% receive some form of treatment. To this end, we summarize the burden of HPV infection and cervical cancer on Filipinos and the risk factors associated with the disease. We present the current screening, diagnostics, treatment, and prevention of HPV-related diseases in the Philippines. Lastly, we also propose solutions on how each building block in health systems can be improved to eliminate HPV infection and reduce the burden of cervical cancer in the Philippines.

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Cervicovaginal Microbiome Factors in Clearance of Human Papillomavirus Infection

Cited by 15 publications

References 106 publications

Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review

Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review

Cervicovaginal microbiota significantly changed for HPV-positive women with high-grade squamous intraepithelial lesion

Current Status of Human Papillomavirus Infection and Cervical Cancer in the Philippines

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