Cesarean delivery and risk of hospitalization for autoimmune disorders before 14 years of age

Soullane, Safiya; Henderson, Mélanie; Kang, Harb; Luu, Thuy Mai; Lee, Ga Eun; Auger, Nathalie

doi:10.1007/s00431-021-04132-w

Cited by 8 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Carlens et al 5 found a borderline statistically significant increase in risk for JIA development in premature children and patients delivered by c-section. Although the differences in results may be a result of our study’s limitations, these findings may be explained by more recent work conducted by Räisänen et al 22 and Soullane et al 21 which make the case that early postnatal antibiotic and breastfeeding delays, respectively, use potentially influences autoimmune disorder development in preterm children. None of the aforementioned studies included antibiotic use in their analysis, thus a definitive statement of antibiotic use and the relationship of complications during pregnancy or labor is difficult to conclude.…”

Section: Discussionmentioning

confidence: 61%

“…However, the existing body of research also presents evidence that challenges this association. Soullane et al 21 is a longitudinal study of 934,873 children that found no statistically significant relationship between CS delivery and the development of autoimmune disorders. The findings of, Räisänen et al 22 also corresponded to those of Soullane et al 21 with no evidence of CS delivery influence on autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Soullane et al 21 is a longitudinal study of 934,873 children that found no statistically significant relationship between CS delivery and the development of autoimmune disorders. The findings of, Räisänen et al 22 also corresponded to those of Soullane et al 21 with no evidence of CS delivery influence on autoimmune disorders. The paradoxical outcomes underscore the potential complexity underpinning the relationship amongst the factors.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Perinatal events and development of juvenile idiopathic arthritis-associated uveitis

Chaudhary,

Nadeem,

Townsend

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Uveitis is one of the most common manifestations of juvenile idiopathic arthritis (JIA). Currently, JIA is associated with decreased gut microbiota diversity. Studies confirm that perinatal events can cause aberrant microbial colonization. The objective of this study is to determine if JIA is associated with perinatal events with a secondary focus on these variables to the development of JIA-uveitis. 369 patients with strabismus (n = 200) or JIA (n = 196) were included in the study. Completed surveys (JIA 37; strabismus 18) collected data about birth route, pregnancy and labor complications, JIA medications, and the presence of eye disorders. Analysis indicates that there is no relationship between JIA development and the perinatal events investigated. Similarly, no significance was found between JIA-uveitis and birth route or labor complications. Pregnancy complications, namely gestational diabetes (GD), were statistically higher in the JIA group with uveitis compared to JIA without uveitis. The data from this survey study showed that JIA-uveitis was highly associated with pregnancy complications, particularly with GD. However, no statistically significant association was found between JIA and route of delivery, labor complications, or pregnancy complications. Further studies are needed to understand the ways that GD interrelates with the development of uveitis in JIA patients.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Perinatal events and development of juvenile idiopathic arthritis-associated uveitis

Chaudhary,

Nadeem,

Townsend

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“… 15 Whether cesarean section is associated with an increased risk for immune-mediated diseases is debated, with the more recent literature showing a very small or no increased risk. 16 , 17 , 18 , 19 The negative impact of cesarean section on later health outcomes is likely to be limited to the elective section and could not be confirmed for the emergency section. 20 The breastfeeding rate is higher in the case of an emergency section than when the section was planned.…”

mentioning

confidence: 99%