Cesarean Section for Placenta Previa and Placenta Previa Accreta Spectrum

Takeda, Satoru; Takeda, Jun; Makino, Shintaro

doi:10.1055/s-0039-3402036

Cited by 19 publications

(37 citation statements)

References 24 publications

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“…This type of amine is valuable because compounds containing 2arylphenethyl-amines are dopamine receptor agonists and could be useful for the production of drugs for the treatment of schizophrenia and Parkinson's disease. 107 Amines of this nature are typically prepared through ring opening of the aziridines with organometallic nucleophiles, such as cuprates, in the presence of strong Lewis acids. 108 The functional group compatibility is limited by both the cuprate and Lewis acid, and alternative methods that operate under milder conditions would be beneficial.…”

Section: Cross-coupling Reactions Of Aziridinesmentioning

confidence: 99%

“…In a fashion analogous to results from nickel-catalyzed Negishi reactions, Takeda and Minakata showed that branched amine products are generated when protected 2-arylaziridines are used in Suzuki-Miyaura reactions (Figure 17b). 107 A notable feature of this reaction is the high stereospecificity, with one enantiomer being formed with high selectivity. In this case, a well-defined palladium(II) precatalyst with an NHC ligand is utilized.…”

Section: Cross-coupling Reactions Of Aziridinesmentioning

confidence: 99%

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Cross-Coupling and Related Reactions: Connecting Past Success to the Development of New Reactions for the Future

2018

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Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in both industry and academia. Even though cross-coupling reactions now represent mature technology, there is still a significant amount of research in this area that aims to improve the scope of these reactions, develop more efficient catalysts, and make reactions more practical. In this tutorial, a brief background to cross-coupling reactions is provided, and then the major advances in crosscoupling research over the last 20 years are described. These include the development of improved ligands and precatalysts for cross-coupling and the extension of cross-coupling reactions to a much wider range of electrophiles. For example, cross-coupling reactions are now common with sp 3 -hybridized electrophiles as well as ester, amide, ether, and aziridine substrates. For many of these more modern substrates, traditional palladium-based catalysts are less efficient than systems based on first-row transition metals such as nickel. Conventional cross-coupling reactions have also inspired the development of a range of related reactions, such as cross-electrophile and decarboxylative couplings as well as couplings based on metallaphotoredox chemistry. The development of these new reactions is probably at the same stage as traditional cross-coupling reactions 30 years ago, and this tutorial highlights how many of the same strategies used to improve cross-coupling reactions may also be applicable to making the new reactions more practical.

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Section: Cross-coupling Reactions Of Aziridinesmentioning

confidence: 99%

Section: Cross-coupling Reactions Of Aziridinesmentioning

confidence: 99%

Cross-Coupling and Related Reactions: Connecting Past Success to the Development of New Reactions for the Future

2018

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“…Patients with indications for these procedures often have concomitant obstetric coagulopathy. Therefore, sufficient supplementation of coagulation factors is also essential prior to surgery [2,7].…”

Section: Surgical Hemostasismentioning

confidence: 99%

“…In the field of obstetrics, TAE is known to be highly effective in controlling uterine hemorrhage and hematoma. This procedure reportedly achieves a high hemostasis rate, and thus, the frequency of hysterectomy has sharply decreased [2,3]. However, complications such as subsequent endometrial hypoplasia, menstruation disorder, infertility, pregnancy loss, placenta accreta, and uterine rupture have been reported, even in cases that have undergone successful hemostasis with TAE using an absorbable embolus [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…However, complications such as subsequent endometrial hypoplasia, menstruation disorder, infertility, pregnancy loss, placenta accreta, and uterine rupture have been reported, even in cases that have undergone successful hemostasis with TAE using an absorbable embolus [4][5][6]. Recently, a minimally invasive hemostatic strategy in obstetrics, which aims to preserve uterine function and enhance the safety of subsequent pregnancies, has been developed [2,7]. Therefore, we should reconsider uterus-preserving hemostatic strategies for critical hemorrhage and management of non-tubal ectopic pregnancy under these circumstances by using safe and minimally invasive treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

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A Minimally Invasive Hemostatic Strategy for Cesarean Scar Pregnancy and Cervical Pregnancy

Takeda¹,

Takeda²,

Yorifuji³

et al. 2020

Non-Tubal Ectopic Pregnancy

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Cesarean scar pregnancy (CSP) and cervical pregnancy are categorized as non-tubal ectopic pregnancy, because these are associated with a high burden of maternal and fetal morbidity including early uterine rupture, prevalence of placenta previa accrete spectrum, massive hemorrhage, and hysterectomy. Although management methods vary according to the week of gestation, recent reviews and reports support an interventional or a combination of surgical and medical approaches for treatment of unruptured CSP and cervical pregnancy rather than medical approach alone. In cases of massive hemorrhage, pressure hemostasis using balloon tamponade should first be performed. If such hemostasis proves to be ineffective, surgical excision or transcatheter arterial embolization (TAE) should be selected next. TAE reportedly achieves a high hemostasis rate. However, complications such as subsequent endometrial hypoplasia, menstruation disorder, infertility, placenta accreta, and uterine rupture have been reported, even in cases that have undergone successful hemostasis with TAE using an absorbable embolus. Recently, a minimally invasive hemostatic strategy in obstetrics, which aims to preserve uterine function and enhance the safety of subsequent pregnancies, has been developed. Therefore, we should reconsider uterus-preserving hemostatic strategies for critical hemorrhage and management of non-tubal ectopic pregnancy under these circumstances by using safe and minimally invasive treatment modalities.

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Formation and Reactivity of New Isoporphyrins: Implications for Understanding the Tyr-His Cross-Link Cofactor Biogenesis in Cytochrome c Oxidase

et al. 2019

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Cytochrome c oxidase (CcO) catalyzes the reduction of dioxygen to water utilizing a heterobinuclear active site composed of a heme moiety and a mononuclear copper center coordinated to three histidine residues, one of which is covalently cross-linked to a tyrosine residue via a post-translational modification (PTM). Although this tyrosine-histidine moiety has functional and structural importance, the pathway behind this net oxidative C-N bond coupling is still unknown. A novel route employing an iron(III) meso-substituted isoporphyrin derivative, isoelectronic with Cmpd-I ((Por •+ )Fe IV =O), is for the first time proposed to be a key intermediate in the Tyr-His cofactor biogenesis. Newly synthesized iron(III) meso-substituted isoporphyrins were prepared with azide, cyanide, and substituted imidazole functionalities, by adding nucleophiles to an iron(III) π-dication species formed via addition of trifluoroacetic acid to F 8 Cmpd-I (F 8 = (tetrakis(2,6-difluorophenyl)porphyrinate)). Isoporphyrin derivatives were characterized at cryogenic temperatures via ESI-MS and UV-vis, 2 H NMR, and EPR spectroscopies. Addition of 1,3,5-trimethoxybenzene or 4-methoxyphenol to the imidazolesubstituted isoporphyrin led to formation of the organic product containing the imidazole coupled to aromatic substrate via a new C-N bond, as detected via cryo-ESI-MS. Experimental evidence for the formation of an imidazole-substituted isoporphyrin and its promising reactivity to form the imidazole-phenol coupled product yields viability to the herein proposed pathway behind the PTM (i.e., biogenesis) leading to the key covalent Tyr-His cross-link in CcO.

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Cesarean Section for Placenta Previa and Placenta Previa Accreta Spectrum

Cited by 19 publications

References 24 publications

Cross-Coupling and Related Reactions: Connecting Past Success to the Development of New Reactions for the Future

Cross-Coupling and Related Reactions: Connecting Past Success to the Development of New Reactions for the Future

A Minimally Invasive Hemostatic Strategy for Cesarean Scar Pregnancy and Cervical Pregnancy

Formation and Reactivity of New Isoporphyrins: Implications for Understanding the Tyr-His Cross-Link Cofactor Biogenesis in Cytochrome c Oxidase

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