Cesarean section increases sensitivity to oxazolone-induced colitis in C57BL/6 mice

Zachariassen, Line F; Hansen, Axel Kornerup; Krych, Łukasz; Nielsen, Dennis Sandris; Holm, Thomas Lindebo; Tougaard, Peter; Hansen, Camilla Hartmann Friis

doi:10.1038/s41385-019-0207-8

Cited by 16 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These immunological effects can be transferred by inoculation of germfree mice with fecal samples from cesarean section-born mice. Furthermore, cesarean section delivery performed in germ-free mice, where the mice were kept germ-free, did not show these immunological effects, again implicating gut microbial differences (31,32). During episodes of acute airway symptoms occurring in our cohort among children between 1 and 4 years of age, we observed that children with a high cesarean section gut microbial score at age 1 year had an overall lower airway immune response.…”

Section: Cesarean Section Microbial Scorementioning

confidence: 61%

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

et al. 2020

View full text Add to dashboard Cite

There have been reports of associations between cesarean section delivery and the risk of childhood asthma, potentially mediated through changes in the gut microbiota. We followed 700 children in the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort prospectively from birth. We examined the effects of cesarean section delivery on gut microbial composition by 16S rRNA gene amplicon sequencing during the first year of life. We then explored whether gut microbial perturbations due to delivery mode were associated with a risk of developing asthma in the first 6 years of life. Delivery by cesarean section was accompanied by marked changes in gut microbiota composition at one week and one month of age, but by one year of age only minor differences persisted compared to vaginal delivery. Increased asthma risk was found in children born by cesarean section only if their gut microbiota composition at 1 year of age still retained a cesarean section microbial signature, suggesting that appropriate maturation of the gut microbiota could mitigate against the increased asthma risk associated with gut microbial changes due to cesarean section delivery.

show abstract

Section: Cesarean Section Microbial Scorementioning

confidence: 61%

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Caesarean sections may increase sensitivity to colitis, 56 probably due to the microbiota‐regulated reduction in Treg cells and an increase in iNKT cells 57 or due to the influence on the colonisation of commensal flora in the gut 58 . A previous study demonstrated that the risk of CD, but not UC, was higher in patients who underwent caesarean delivery (OR = 1.38) 2 .…”

Section: Discussionmentioning

confidence: 99%

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

Zhao

Feng

Ben‐Horin

et al. 2021

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background While the incidence of inflammatory bowel disease (IBD) has stabilised in the West, it is still increasing in several newly industrialised countries. Aims To investigate whether the environmental and dietary risk factors for IBD differ between Eastern and Western populations Methods We systematically searched PubMed, Embase, and Web of Science for studies published from inception through June 30, 2020. Data were pooled using a random effects model. Results Overall, 255 studies were assessed. We identified 25 risk factors for IBD, seven of which were noted in both Eastern and Western populations: family history of Crohn's disease [CD] or ulcerative colitis [UC], former smoking (CD/UC), smoking (CD), appendicectomy (CD), tonsillectomy (CD), meat and meat products (CD), and vitamin D deficiency (UC). The remaining factors, including urban living, current smoking, antibiotics, oral contraceptives, caesarean section, isotretinoin, total energy, fat, cholesterol, fatty acids and their sub‐classifications, eggs, and soft drinks, were associated with an increased risk of IBD in Western or Eastern populations only. We identified 21 protective factors for IBD, among which eight were common in the East and West: farm animals (CD/UC), Helicobacter pylori infection (CD/UC), multiple births (CD), physical activity (CD), history of breastfeeding (CD), pets (UC), current smoking (UC), and coffee intake (UC). Ten factors conferred protection against IBD in Western populations only, whereas eight factors conferred protection against IBD in Eastern populations only. Conclusions Numerous environmental and dietary factors influenced the development of IBD in both Western and Eastern populations, whereas certain factors influenced IBD risk differently in these populations.

show abstract

“…In an oxazolone colitis model, CSD mice were more sensitive to the treatment than VD mice, including higher concentrations of TNF-alpha and inflammation markers in the colon. This phenotype was transferred to germ-free mice when inoculated with CSD and VD mouse microbiota [52]. A murine model has shown social, cognitive, and anxiety deficits, both in early life and adulthood.…”

Section: Higher Risk Of Leukemia and Lymphoblastic Leukemiamentioning

confidence: 99%

From Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health

2021

View full text Add to dashboard Cite

The establishment of gut microbiota has been proven to be impacted by several factors during pregnancy, delivery, and neonate periods. The body of evidence describing C-section delivery (CSD) as one of the most disruptive events during early life has expanded in recent years, concluding that CSD results in a drastic change in microbiota establishment patterns. When comparing the gut microbiota composition of CSD babies with vaginally delivered (VD) babies, the former show a microbiome that closely resembles that found in the environment and the mother’s skin, while VD babies show a microbiome more similar to the vaginal microbiome. Although these alterations of normal gut microbiota establishment tend to disappear during the first months of life, they still affect host health in the mid–long term since CSD has been correlated with a higher risk of early life infections and non-transmissible diseases, such as inflammatory diseases, allergies, and metabolic diseases. In recent years, this phenomenon has also been studied in other mammals, shedding light on the mechanisms involved in the effects of a CSD on host health. In addition, strategies to revert the disruptions in gut microbiomes caused by a CSD are currently in the process of development and evaluation. In this review, we discuss the recent advances in CSD research, from the alteration of gut microbiota establishment to the possible effects on host health during early life and development.

show abstract

Cesarean section increases sensitivity to oxazolone-induced colitis in C57BL/6 mice

Cited by 16 publications

References 50 publications

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Systematic review with meta‐analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations

From Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health

Contact Info

Product

Resources

About